Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Amy Maden"'
Autor:
Barbara D. Foleno, Steven M. Crespo-Carbone, Darren Abbanat, Amy Maden, Raul Goldschmidt, Karen Bush, Ellen Z. Baum
Publikováno v:
Antimicrobial Agents and Chemotherapy. 50:230-236
MurF is a key enzyme in the biosynthesis of the bacterial cell wall in both gram-positive and gram-negative bacteria. This enzyme has not been extensively exploited as a drug target, possibly due to the difficulty in obtaining one of the substrates,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4b3637b1f5285771d4fec0dcbf98c5
https://doi.org/10.1128/aac.50.1.230-236.2006
https://doi.org/10.1128/aac.50.1.230-236.2006
Publikováno v:
Tetrahedron Letters. 43:7389-7392
Preparation of densely functionalized pyrrolidinone templates, is a challenge for synthetic chemists. These templates are important building blocks for novel conformationally constrained natural products or for library generation of highly functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aaa3ff7042d4e9df39ee0a8742510bb2
https://doi.org/10.1016/s0040-4039(02)01711-2
https://doi.org/10.1016/s0040-4039(02)01711-2
Publikováno v:
Tetrahedron. 58:3159-3170
Intramolecular nitrone cycloadditions using amino acid precursors, generate aminohydroxyazepine and amino hydroxypiperidine templates. The cycloaddition reactions yield either a [4.3.0] fused system or in most cases a [4.2.1] bridged system. The [4.2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5130b80894ec870edb24fd2e0e27b08e
https://doi.org/10.1016/s0040-4020(02)00242-9
https://doi.org/10.1016/s0040-4020(02)00242-9
Publikováno v:
The Journal of Organic Chemistry. 72:3097-3099
The nitrone above is readily available via the intramolecular aza Diels−Alder reaction of an amino acid derived triene in acetic acid. Subsequent treatment of the nitrone in refluxing toluene with substituted actetylenes produced the pictured pyrro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec25b21ac5197d41088d2dd744c2bde
https://doi.org/10.1021/jo062579a
https://doi.org/10.1021/jo062579a
Publikováno v:
Tetrahedron Letters. 46:1783-1785
A novel series of 11,12-benzoxazine ketolide derivatives of erythromycin A has been synthesized. The C11,C12-benzoxazine structure was constructed stereoselectively through an intramolecular Michael addition of a C12- O -(2-aminophenyl) group to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65ce3637d38187f86342f3884adcb66e
https://doi.org/10.1016/j.tetlet.2005.01.126
https://doi.org/10.1016/j.tetlet.2005.01.126
Publikováno v:
ChemInform. 33
Intramolecular nitrone cycloadditions using amino acid precursors, generate aminohydroxyazepine and amino hydroxypiperidine templates. The cycloaddition reactions yield either a [4.3.0] fused system or in most cases a [4.2.1] bridged system. The [4.2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fcb04b09f62074b86d54eddc18732ab
https://doi.org/10.1002/chin.200237167
https://doi.org/10.1002/chin.200237167
Publikováno v:
ChemInform. 33
Preparation of densely functionalized pyrrolidinone templates, is a challenge for synthetic chemists. These templates are important building blocks for novel conformationally constrained natural products or for library generation of highly functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37dfefeb1a2b470d30f24aa777fe1c36
https://doi.org/10.1002/chin.200252105
https://doi.org/10.1002/chin.200252105
Publikováno v:
ChemInform. 35
[structure: see text] Intramolecular [4 + 2] cycloaddition using alpha,beta-unsaturated oximes was explored. The reactions proceeded under unusually facile conditions to furnish the nitrones. The latter were subsequently reacted with DMAD to afford [
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc9bb841c862d0e23707e31e1bd2484
https://doi.org/10.1002/chin.200440189
https://doi.org/10.1002/chin.200440189
Publikováno v:
ChemInform. 35
The diastereoselective synthesis of a series of 1-oxo-1,2,3,3a,4,7a-hexahydro-pyrano[3,4-c]pyrrole-4-carboxylic acid ethyl esters via an oxo Diels–Alder reaction is described. Ab initio calculations predicted the products of the exo cycloaddition t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b776edd85a967f799204bc428849b631
https://doi.org/10.1002/chin.200410130
https://doi.org/10.1002/chin.200410130