Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Amy M. Pooler"'
Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons
Autor:
Teresa Rodríguez-Martín, Amy M. Pooler, Dawn H.W. Lau, Gábor M. Mórotz, Kurt J. De Vos, Jonathan Gilley, Michael P. Coleman, Diane P. Hanger
Publikováno v:
Neurobiology of Disease, Vol 85, Iss , Pp 1-10 (2016)
Expression of the frontotemporal dementia-related tau mutation, P301L, at physiological levels in adult mouse brain (KI-P301L mice) results in overt hypophosphorylation of tau and age-dependent alterations in axonal mitochondrial transport in periphe
Externí odkaz:
https://doaj.org/article/4d3a2fdfc4214f45aec1f1bd18eaaefc
Persistent repression of tau in the brain using engineered zinc finger protein transcription factors
Autor:
Susanne Wegmann, Bradley T. Hyman, Annemarie Ledeboer, Jeffrey C. Miller, Marta Perez-Rando, Kimberly Marlen, Richard T. Surosky, Bryan Zeitler, Caitlin Commins, Alison Chase, Michael C. Holmes, Sarah J. Hinkley, Alicia Goodwin, Riley N. Bannon, Lei Zhang, Brigit E. Riley, Hoang-Oanh B. Nguyen, Sarah L. DeVos, Edward J. Rebar, Ashley B. Robbins, Stephen Lam, Rainier Amora, Irina Ankoudinova, Qi Yu, Amy M. Pooler, Hung Tran, Nicholas A. Scarlott, Bianca T. Corjuc, Danny MacKenzie, Fyodor D. Urnov, H. Steve Zhang, Lisa Diez, Rachel E. Bennett
Publikováno v:
Science advances 7(12), eabe1611-(2021). doi:10.1126/sciadv.abe1611
Science Advances
Science Advances
Zinc finger proteins targeted to MAPT safely repress tau mRNA in the adult mouse brain and protect against Aβ toxicity.
Neuronal tau reduction confers resilience against β-amyloid and tau-related neurotoxicity in vitro and in vivo. Here, we in
Neuronal tau reduction confers resilience against β-amyloid and tau-related neurotoxicity in vitro and in vivo. Here, we in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1e249560ae8a0539e415f467dba78e
Autor:
Alfonso M. Lechuga-Sancho, Tara L. Spires-Jones, Amy M. Pooler, Brian J. Bacskai, Juan Jose Ramos-Rodriguez, Monica Garcia-Alloza
Publikováno v:
Ramos-Rodriguez, J J, Spires-Jones, T, Pooler, A M, Lechuga-Sancho, A M, Bacskai, B J & Garcia-Alloza, M 2016, ' Progressive Neuronal Pathology and Synaptic Loss Induced by Prediabetes and Type 2 Diabetes in a Mouse Model of Alzheimer's Disease ', Molecular Neurobiology, vol. 53 . https://doi.org/10.1007/s12035-016-9921-3
Age remains the main risk factor for developing Alzheimer's disease (AD) although certain metabolic alterations, including prediabetes and type 2 diabetes (T2D), may also increase this risk. In order to understand this relationship, we have studied a
Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice
Autor:
Brian H. Anderton, Laura Sturdee, Michael P. Coleman, Jean Pierre Brion, Diane P. Hanger, Jonathan Gilley, Teresa Rodriguez-Martin, Amy M. Pooler, Kunie Ando, Anjan Seereeram
Publikováno v:
Neurobiology of aging, 39
Gilley, J, Ando, K, Seereeram, A, Rodríguez-Martín, T, Pooler, A M, Sturdee, L, Anderton, B H, Brion, J-P, Hanger, D P & Coleman, M P 2016, ' Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice ', Neurobiology of Aging, vol. 39, pp. 1-18 . https://doi.org/10.1016/j.neurobiolaging.2015.11.028
Gilley, J, Ando, K, Seereeram, A, Rodríguez-Martín, T, Pooler, A M, Sturdee, L, Anderton, B H, Brion, J-P, Hanger, D P & Coleman, M P 2016, ' Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice ', Neurobiology of Aging, vol. 39, pp. 1-18 . https://doi.org/10.1016/j.neurobiolaging.2015.11.028
Hyperphosphorylation and fibrillar aggregation of the microtubule-associated protein tau are key features of Alzheimer's disease and other tauopathies. To investigate the involvement of tau phosphorylation in the pathological process, we generated a
Publikováno v:
Neuropharmacology. 76:1-8
Alzheimer's disease (AD) is characterized by brain deposition of amyloid plaques and tau neurofibrillary tangles along with steady cognitive decline. Although the mechanism by which AD pathogenesis occurs is unclear, accumulating evidence suggests th
Autor:
Cara L, Croft, Matthew A, Wade, Ksenia, Kurbatskaya, Pavlina, Mastrandreas, Martina M, Hughes, Emma C, Phillips, Amy M, Pooler, Michael S, Perkinton, Diane P, Hanger, Wendy, Noble
Publikováno v:
Cell Death & Disease
The spatiotemporal transmission of pathological tau in the brain is characteristic of Alzheimer's disease. Release of both soluble and abnormal tau species from healthy neurons is increased upon stimulation of neuronal activity. It is not yet underst
Autor:
Kevin R Kay, Tara L. Spires-Jones, Laura Sanchez, Amy M. Pooler, Teresa Gomez-Isla, Rose Pitstick, Bradley T. Hyman, George A. Carlson, Manuela Polydoro, Susanne Wegmann, Mark W. Albers
Publikováno v:
Journal of Comparative Neurology. 521:4236-4248
Early observations of the patterns of neurofibrillary tangles and amyloid plaques in Alzheimer's disease suggested a hierarchical vulnerability of neurons for tangles, and a widespread nonspecific pattern of plaques that nonetheless seemed to correla
Autor:
Jennifer I. Luebke, Johanna L. Crimins, Manuela Polydoro, Amy M. Pooler, Tara L. Spires-Jones
Publikováno v:
Ageing Research Reviews. 12:757-763
The synaptic connections that form between neurons during development remain plastic and able to adapt throughout the lifespan, enabling learning and memory. However, during aging and in particular in neurodegenerative diseases, synapses become dysfu
Publikováno v:
EMBO Reports
Physiological release of endogenous tau is stimulated by neuronal activity This report provides evidence that stimulation of neuronal activity, or AMPA receptor activation, induces tau release from cortical neurons via a calcium-dependent mechanism.
Autor:
Christopher William, Sarah L. DeVos, Eduardo A Maury, Bradley T. Hyman, Lubna Saqran, Ozge Cagsal-Getkin, Zhanyun Fan, Rose Pitstick, Molly J. Kirk, Tara L. Spires-Jones, Amy M. Pooler, Allyson D. Roe, Samantha B. Nicholls, Susanne Wegmann, Shuko Takeda, George A. Carlson
Publikováno v:
Spires-Jones, T, Wegmann, S K, Maury, E A, Kirk, M, Saqran, L, Roe, A D & DeVos, S 2015, ' Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity ', EMBO Journal, vol. 34, no. 24, pp. 3028-3041 . https://doi.org/10.15252/embj.201592748
The EMBO Journal
The EMBO Journal
In Alzheimer's disease and tauopathies, tau protein aggregates into neurofibrillary tangles that progressively spread to synaptically connected brain regions. A prion-like mechanism has been suggested: misfolded tau propagating through the brain seed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd9b0fa2f4ee9028fba7adac083773e1
https://europepmc.org/articles/PMC4687785/
https://europepmc.org/articles/PMC4687785/