Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Amy M. Kadell"'
Autor:
Manu R. Varma, Thomas W. Wakefield, Minaski Sarkar, Peter K. Henke, Angela E. Hawley, Amy M. Kadell, Marisa J. Linn, Robert M. Strieter, J. Brian Fowlkes
Publikováno v:
Journal of Surgical Research. 99:84-91
Background. Therapy for deep vein thrombosis (DVT) resolution in those patients in whom a complication or contraindication to anticoagulation occurs is limited. As prior work suggests that thrombus maturation involves early influx of neutrophils (PMN
Autor:
Sandra L. Brown, Martin R. Prince, Lazar J. Greenfield, Shirley K. Wrobleski, Daniel D. Myers, Peter K. Henke, Frank J. Londy, Robert G. Schaub, Amy M. Kadell, Thomas W. Wakefield, Robert M. Strieter
Publikováno v:
Journal of Vascular Surgery. 31:309-324
Objective: This study was performed to determine the effectiveness of recombinant P-selectin glycoprotein ligand Ig (rPSGL-Ig) pretreatment to decrease thrombosis and inflammation in experimental venous thrombosis. rPSGL-Ig, a unique mucin-like glyco
Autor:
L. Joseph Downing, Robert M. Strieter, Amy M. Kadell, Carol A. Wilke, John C. Austin, Bradley D. Hare, Marie D. Burdick, Lazar J. Greenfield, Thomas W. Wakefield
Publikováno v:
The Journal of Immunology. 161:1471-1476
Vein wall inflammation associated with venous thrombosis is mediated by an imbalance in proinflammatory as compared with antiinflammatory molecules. We hypothesize that IL-10 is an important antiinflammatory cytokine that influences vein wall inflamm
Autor:
Lazar J. Greenfield, Donald C. Anderson, Shirley K. Wrobleski, Frank J. Londy, M. S. Hulin, Marie D. Burdick, S. L. Brown, Martin R. Prince, Amy M. Kadell, Thomas W. Wakefield, L. J. Downing, Carol A. Wilke, J. B. Fowlkes, Robert M. Strieter
Publikováno v:
Journal of Vascular Surgery. 25(5):816-828
Purpose: Venous thrombosis and inflammation are interrelated. P-selectin contributes to activation of leukocyte-mediated inflammation. Therefore, we hypothesized that the neutralization of P-selectin would decrease vein wall inflammation and thrombos
Autor:
Thomas W. Wakefield, James C. Stanley, Philip C. Andrews, Samir Tejwani, Shirley K. Wrobleski, Amy M. Kadell, Regina Schmidt
Publikováno v:
Journal of Vascular Surgery. 21:839-850
This investigation assessed protamine reversal of heparin anticoagulation by formation of a protamine-heparin alpha-helix by use of a new designer-variant protamine [+18BE] that was made from an existing protamine variant [+18B] whose non-alpha-helix
Autor:
Thomas W. Wakefield, Amy M. Kadell, Lazar J. Greenfield, Shirley K. Wrobleski, Regina Schmidt, Steven L. Kunkel, Carol A. Wilke, Robert M. Strieter, Marie D. Burdick
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 15:258-268
Abstract Thrombosis and inflammation are closely related. However, the response of the vein wall to venous thrombosis has been poorly documented. This study examines the hypothesis that venous thrombosis is associated with an inflammatory response in
Autor:
Thomas W. Wakefield, Amy M. Kadell, James C. Stanley, Philip C. Andrews, Alphonse DeLucia, Shirley K. Wrobleski, Brad J. Nichol, L.Joe Downing
Publikováno v:
Journal of Vascular Surgery. 18:49-60
Purpose: The role of total cationic charge of synthetic protamine-like peptides in heparin anticoagulation reversal and accompanying adverse hemodynamic effects was studied. Methods: Five protamine variants having specific total charges of [+8], [+16
Autor:
Shirley K. Wrobleski, Thomas W. Wakefield, Marcian VanDort, Alphonse DeLucia, James C. Stanley, Amy M. Kadell
Publikováno v:
ASAIO Journal. 39:M715-M718
Intravenous protamine reversal of heparin anticoagulation may cause adverse hemodynamic side effects, but little is known about protamine's tissue distribution, circulating half-life (t/2), and excretion. The latter were assessed by examining 125I Bo
Autor:
Charles T. Esmon, Lazar J. Greenfield, Fletcher B. Taylor, Mark W. Rolfe, Amy M. Kadell, Steven L. Kunkel, Thomas W. Wakefield, Gerald D. Abrams, Marie D. Burdick, Alphonse DeLucia, Shirley K. Wrobleski, Robert M. Strieter
Publikováno v:
Thrombosis and Haemostasis. 69:164-172
SummaryTheoretic and in vitro evidence suggests that thrombosis and inflammation are interrelated. The purpose of the present study was to define the relationship between inflammation and deep venous thrombosis (DVT) in an in vivo model. Initiation o
Publikováno v:
Journal of Vascular Surgery. 16:47-53
Protamine sulfate causes direct myocardial suppression when used to reverse heparin anticoagulation. Protamine's excessive positive charge accompanying its surface arginine groups appears to be responsible for this toxicity. This study was designed t