Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Amy L. Ulfers"'
Publikováno v:
Biochemistry. 41:11344-11350
The third cytoplasmic loop (IC3) is a determinant in the dynamic life cycle of G protein-coupled receptors, including the activation, internalization, desensitization, and resensitization processes. Here, we characterize the structural features of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff3e50be760aef86cd794999f8457ab9
https://doi.org/10.1021/bi0259610
https://doi.org/10.1021/bi0259610
Publikováno v:
Biopolymers. 66:339-349
The technical difficulties associated with the structure determination of membrane proteins have limited the structural information available for the ligand binding to G-protein coupled receptors (GPCRs). Here, we describe a reductionist approach to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ed1f9bf0df8a0193897ca81e4f3af2
https://doi.org/10.1002/bip.10312
https://doi.org/10.1002/bip.10312
Publikováno v:
Journal of Biological Chemistry. 276:22862-22867
Molecular models for the interaction of substance P (SP) with its G protein-coupled receptor, the neurokinin-1 receptor (NK-1R), have been developed. The ligand·receptor complex is based on experimental data from a series of photoaffinity labeling e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0f58b3f6060041f394372d3b85c4fc2
https://doi.org/10.1074/jbc.m101057200
https://doi.org/10.1074/jbc.m101057200
Autor:
Amy L. Ulfers, Dale F. Mierke, Alexander Miller, Jonathan L. McMurry, Ligong Wang, Debra A. Kendall
Publikováno v:
Protein science : a publication of the Protein Society. 11(10)
The structure of the C-terminal region of the third cytoplasmic loop (IC3) of the cannabinoid receptor one (CB1) bound to G(alphai1) has been determined using transferred nuclear Overhauser effects (NOEs). The wild-type IC3 sequence is helical when a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d6db0ae13c8bc1150f4e7dd9b58cfb
https://pubmed.ncbi.nlm.nih.gov/12237474
https://pubmed.ncbi.nlm.nih.gov/12237474