Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Amy L. Stiegler"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Inhibition of DLC1 RhoGAP by p120RasGAP allows for crosstalk between the Rho and Ras pathways. Here, Chau et al. present the co-crystal structure of DLC1 RhoGAP domain and p120RasGAP SH3 domain and probe the interaction with biochemical studies.
Externí odkaz:
https://doaj.org/article/779ad6e9718c41c98878a7eae9466b67
Autor:
Amy L. Stiegler, Titus J. Boggon
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
A growing number of ‘pseudoenzymes’ with a regulatory role in signal transduction processes but without catalytic activity are being identified. Here, the authors identify two pseudoGTPase domains in p190RhoGAP, characterize them biochemically an
Externí odkaz:
https://doaj.org/article/9cd51f99991242e7909c8e191046ed0e
Autor:
Andrew T. Timberlake, Stephen McGee, Garrett Allington, Emre Kiziltug, Erin M. Wolfe, Amy L. Stiegler, Titus J. Boggon, May Sanyoura, Michelle Morrow, Tara L. Wenger, Erica M. Fernandes, Oana Caluseriu, John A. Persing, Sheng Chih Jin, Richard P. Lifton, Kristopher T. Kahle, Paul Kruszka
Publikováno v:
The American Journal of Human Genetics. 110:846-862
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88afd7996bcebbdc97470493c1cea232
https://doi.org/10.1016/j.ajhg.2023.03.017
https://doi.org/10.1016/j.ajhg.2023.03.017
Publikováno v:
Structure (London, England : 1993). 30(12)
p120RasGAP is a multidomain GTPase-activating protein for Ras. The presence of two Src homology 2 domains in an SH2-SH3-SH2 module raises the possibility that p120RasGAP simultaneously binds dual phosphotyrosine residues in target proteins. One known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b61f2c8bb6aa2ce0d9fc781e563c2e4
https://pubmed.ncbi.nlm.nih.gov/36417908
https://pubmed.ncbi.nlm.nih.gov/36417908
Autor:
Andrew T, Timberlake, Emre, Kiziltug, Sheng Chih, Jin, Carol, Nelson-Williams, Erin, Loring, August, Allocco, Arnaud, Marlier, Siddharth, Banka, Helen, Stuart, Maria Rita, Passos-Buenos, Rafael, Rosa, Silvia R, Rogatto, Elin, Tonne, Amy L, Stiegler, Titus J, Boggon, Michael, Alperovich, Derek, Steinbacher, David A, Staffenberg, Roberto L, Flores, John A, Persing, Kristopher T, Kahle, Richard P, Lifton
Publikováno v:
Human genetics.
Lambdoid craniosynostosis (CS) is a congenital anomaly resulting from premature fusion of the cranial suture between the parietal and occipital bones. Predominantly sporadic, it is the rarest form of CS and its genetic etiology is largely unexplored.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::32792606752e5d5f74de89d76fe12d14
https://pubmed.ncbi.nlm.nih.gov/35997807
https://pubmed.ncbi.nlm.nih.gov/35997807
Publikováno v:
J Biol Chem
The Src homology 2 (SH2) domain has a highly conserved architecture that recognizes linear phosphotyrosine motifs and is present in a wide range of signaling pathways across different evolutionary taxa. A hallmark of SH2 domains is the arginine resid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896abebc06de6b91452d2daab1e3ba93
https://doi.org/10.1074/jbc.ra120.013976
https://doi.org/10.1074/jbc.ra120.013976
Autor:
Gloria S. Huang, Roberto Angioli, Titus J. Boggon, Weilai Dong, Ludmil B. Alexandrov, Gulden Menderes, Elena Bonazzoli, Francesco Raspagliesi, Richard P. Lifton, Chanhee Han, Aranzazu Manzano, Franco Odicino, Peter E. Schwartz, Antonella Ravaggi, Kaya Bilguvar, Emanuele Perrone, Laura Zanotti, Elena Ratner, Salvatore Lopez, Laura Ardighieri, Joseph Schlessinger, Valentina Pirazzoli, Jungmin Choi, Gary Altwerger, Francesca Pettinella, Siming Zhao, Alessandro D. Santin, Masoud Azodi, Carla Donzelli, Luca Zammataro, Natalia Buza, Paola Todeschini, Burak Zeybek, Dan-Arin Silasi, Eliana Bignotti, Stefania Bellone, Sergio Pecorelli, Pei Hui, Chiara Romani, Serena Wong, Amy L. Stiegler, Emiliano Cocco, Paola Manara, Giovanni Scambia, Anna Bianchi
Publikováno v:
Proceedings of the National Academy of Sciences. 116:22730-22736
The prognosis of advanced/recurrent cervical cancer patients remains poor. We analyzed 54 fresh-frozen and 15 primary cervical cancer cell lines, along with matched-normal DNA, by whole-exome sequencing (WES), most of which harboring Human-Papillomav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eacce8090477cbd4c820639e08dff8b9
https://doi.org/10.1073/pnas.1911385116
https://doi.org/10.1073/pnas.1911385116
Mutations in ILK, encoding integrin-linked kinase, are associated with arrhythmogenic cardiomyopathy
Autor:
Tatjana Williams, Daniel Liedtke, Henry J. Duff, Nicole M. Munsie, Jan M. Friedman, Saman Rezazadeh, William T. Gibson, Brenda Gerull, Raechel A. Ferrier, Steven J.M. Jones, Yaoqing Shen, Amy L. Stiegler, Titus J. Boggon, Andreas Brodehl, Tracey Oh, Sarah J. Childs
Publikováno v:
Transl Res
Arrhythmogenic cardiomyopathy is a genetic heart muscle disorder characterized by fibro-fatty replacement of cardiomyocytes leading to life-threatening ventricular arrhythmias, heart failure and sudden cardiac death. Mutations in genes encoding cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd22c63ae5c28028a3c33dcbc4718c08
https://doi.org/10.1016/j.trsl.2019.02.004
https://doi.org/10.1016/j.trsl.2019.02.004
Autor:
Natasha L. Rudy, Anna C.E. Hurst, Alexander Marson, Steven H. Kroft, James Garifallou, Sarah K. Nicholas, Piyush Pillarisetti, Gerald Wertheim, Di Sun, Andrew D. Wells, Titus J. Boggon, Gregory M.K. Poon, Kelly Maurer, Brian Nolan, Caroline Khanna, Francis Wright, Jennifer M. Puck, Struan F.A. Grant, Suela Xhani, Amy Rymaszewski, Ivan K. Chinn, Viktoria Zakharova, Samuel Yoon, James W. Verbsky, Neil Romberg, David N. Nguyen, Linda T. Vo, Kathleen E. Sullivan, Chun Su, Anna Shcherbina, Alix E. Seif, T. Prescott Atkinson, Amy L. Stiegler, Hakon Hakonarson, Anna Mukhina, Amanda V. Albrecht, Timothy S. Olson, Peixin Amy Chen, John M. Routes, Benjamin Demaree, Joud Hajjar, James R. Lupski, Adam R. Abate, Michael Gonzalez, Carole Le Coz
Publikováno v:
Journal of Experimental Medicine. 218
The pioneer transcription factor (TF) PU.1 controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing nonpioneer TFs to enter otherwise inaccessible genomic sites. PU.1 deficiency fatally arrests lymphopoiesis and myelopo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30f4dc0a4c4b9707b814c76958472437
https://doi.org/10.1084/jem.20201750
https://doi.org/10.1084/jem.20201750
Autor:
Amy L Stiegler, Thomas D Grant, Joseph R Luft, David A Calderwood, Edward H Snell, Titus J Boggon
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55591 (2013)
The heterotrimeric protein complex containing the integrin linked kinase (ILK), parvin, and PINCH proteins, termed the IPP complex, is an essential component of focal adhesions, where it interacts with many proteins to mediate signaling from integrin
Externí odkaz:
https://doaj.org/article/6a1e5d283b594e66aeaa98d536348e31