Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Amy L. Rice"'
Autor:
Kristin L. Begley, Amy L. Rice, Jean-Claude Dujardin, Jonah Rector, Vivek M. Rangnekar, Corinne M. Fargo, David S. Watt, Yizhe Chen, Diana Ortiz, Liliia M. Kril, Vitaliy M. Sviripa, Ho Shin Kim, Scott M. Landfear, Malgorzata A. Domagalska, Jared T. Hammill, Chunming Liu, R. Kiplin Guy
Publikováno v:
Journal of Medicinal Chemistry
Leishmaniasis, a disease caused by protozoa of the Leishmania species, afflicts roughly 12 million individuals worldwide. Most existing drugs for leishmaniasis are toxic, expensive, difficult to administer, and subject to drug resistance. We report a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb60386e9c3a23c7edf6eb57fe754e45
http://europepmc.org/articles/PMC8404201
http://europepmc.org/articles/PMC8404201
Autor:
Marc O. Anderson, Martina Sigal, Ashley Cheung, Jared T. Hammill, Anna S Kashtanova, Korina Eribez, Lauren Loop, Horacio Lazaro, Irene García-Barbazán, Cory A. Chaplan, Kenya Yniguez, Benigno Crespo, Alisje Churchyard, Mofolusho O. Falade, Grant Koch, Briana Belanger, Celine DiBernardo, Jake Baum, Julia E Tryhorn, Amy L. Rice, Katie Kim, Joshua J. Kimball, R. Kiplin Guy, Steven Wilkinson, Benoît Laleu, Nimisha Mittal, Rei Takahashi, Elizabeth A. Winzeler, Francisco-Javier Gamo, Scott Eagon, Kevin J Ahn
Publikováno v:
Journal of Medicinal Chemistry. 63:11902-11919
Malaria remains one of the most deadly infectious diseases, causing hundreds of thousands of deaths each year, primarily in young children and pregnant mothers. Here, we report the discovery and derivatization of a series of pyrazolo[3,4-b]pyridines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b79d343cc463a5cc1561c5e53694b2dc
https://doi.org/10.1021/acs.jmedchem.0c01152
https://doi.org/10.1021/acs.jmedchem.0c01152
Autor:
Brandon Nguyen, Julia Elizabeth Glidden, Scott Eagon, Kasey Fitzsimmons, Jared T. Hammill, Kara Thompson, Jarvis Law, Mofolusho O. Falade, Steven Wilkinson, Amy L. Rice, Celine DiBernardo, Natalie Sienko, R. Kiplin Guy, Aashrita Manjunath, Joshua J. Kimball
Publikováno v:
Bioorganicmedicinal chemistry letters. 47
Malaria remains one of the deadliest diseases on the planet, infecting an estimated 229 million individuals in 2019 with more than 400,000 associated deaths, primarily in young children and pregnant women. 1 Malaria is caused by Plasmodium parasite i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b242d421005f920cc4d5a97d076ff9f
https://pubmed.ncbi.nlm.nih.gov/34157390
https://pubmed.ncbi.nlm.nih.gov/34157390
Autor:
Bhuvanesh Singh, Yizhe Chen, William Pistel, R. Kiplin Guy, Amy L. Rice, Daniel C. Scott, Jared T. Hammill, Ho Shin Kim, Brenda A. Schulman
Publikováno v:
Journal of medicinal chemistry. 64(9)
The cullin-RING ubiquitin ligases (CRLs) are ubiquitin E3 enzymes that play a key role in controlling proteasomal degradation and are activated by neddylation. We previously reported inhibitors that target CRL activation by disrupting the interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f25558c69a296f741f80f31324855f
https://pubmed.ncbi.nlm.nih.gov/33945681
https://pubmed.ncbi.nlm.nih.gov/33945681
Publikováno v:
Bulletin of the World Health Organization, Vol 78, Iss 10, Pp 1207-1221 (2000)
INTRODUCTION: Recent estimates suggest that malnutrition (measured as poor anthropometric status) is associated with about 50% of all deaths among children. Although the association between malnutrition and all-cause mortality is well documented, the
Externí odkaz:
https://doaj.org/article/e17bcfdd128e423188f1f8c650e65196
Autor:
Jordan Bach, Jared T. Hammill, Mofolusho O. Falade, R. Kiplin Guy, Scott Eagon, Nikalet Everson, Amy L. Rice
Publikováno v:
Bioorganicmedicinal chemistry letters. 35
A virtual screen was performed to identify anti-malarial compounds targeting Plasmodium falciparum heat shock 90 protein by applying a series of drug-like and commercial availability filters to compounds in the ZINC database, resulting in a virtual l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a9ad5db5011f78f7ce1ef23d4cd16c5
https://pubmed.ncbi.nlm.nih.gov/33513390
https://pubmed.ncbi.nlm.nih.gov/33513390
Autor:
Scott, Eagon, Jared T, Hammill, Martina, Sigal, Kevin J, Ahn, Julia E, Tryhorn, Grant, Koch, Briana, Belanger, Cory A, Chaplan, Lauren, Loop, Anna S, Kashtanova, Kenya, Yniguez, Horacio, Lazaro, Steven P, Wilkinson, Amy L, Rice, Mofolusho O, Falade, Rei, Takahashi, Katie, Kim, Ashley, Cheung, Celine, DiBernardo, Joshua J, Kimball, Elizabeth A, Winzeler, Korina, Eribez, Nimisha, Mittal, Francisco-Javier, Gamo, Benigno, Crespo, Alisje, Churchyard, Irene, García-Barbazán, Jake, Baum, Marc O, Anderson, Benoît, Laleu, R Kiplin, Guy
Publikováno v:
Journal of medicinal chemistry. 63(20)
Malaria remains one of the most deadly infectious diseases, causing hundreds of thousands of deaths each year, primarily in young children and pregnant mothers. Here, we report the discovery and derivatization of a series of pyrazolo[3,4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7e9b7615d65f5856c40bca0cc86bf7b8
https://pubmed.ncbi.nlm.nih.gov/32945666
https://pubmed.ncbi.nlm.nih.gov/32945666
Autor:
Amy L. Rice, Celine DiBernardo, Jordan Bach, Tyler A Sisley, Scott Eagon, R. Kiplin Guy, Mofolusho O. Falade, Sierra D. Durham, Nikalet Everson, Joshua J. Kimball, Dylan R. Pillai, Michael J. Walls, Jared T. Hammill, Horacio Lazaro
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(21)
A series of tetrahydro-β-carboline derivatives of a lead compound known to target the heat shock 90 protein of Plasmodium falciparum were synthesized and assayed for both potency against the parasite and toxicity against a human cell line. Using a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae6e24616f77f17e1ad702d12cbcb3db
https://pubmed.ncbi.nlm.nih.gov/32822760
https://pubmed.ncbi.nlm.nih.gov/32822760
Autor:
Zenaide M.N. Quezado, Raissa Nobrega, Julia C. Finkel, Caroline Lippold, Kathy A Sheehy, Amy L Rice
Publikováno v:
Pediatric Research. 83:445-454
BackgroundN-methyl-D-aspartate receptor activation has been implicated in the pathobiology of inflammatory, nociceptive and neuropathic pain, opioid tolerance, opioid-induced hyperalgesia, and central sensitization. Some of those mechanisms underlie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbde111f86bca5a43b1b3b77bb7f0320
https://doi.org/10.1038/pr.2017.197
https://doi.org/10.1038/pr.2017.197
Autor:
Amy L Rice, Julia C. Finkel, Raissa Nobrega, Kathy A Sheehy, Zenaide M.N. Quezado, Caroline Lippold
Publikováno v:
Journal of Pain Research
Kathy A Sheehy,1,* Caroline Lippold,1,* Amy L Rice,1 Raissa Nobrega,1 Julia C Finkel,1 Zenaide MN Quezado1,2 1Division of Anesthesiology, Pain, and Perioperative Medicine, The Sheikh Zayed Institute for Pediatric Surgical Innovation, Children’s Res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::125bae6e46498b3ea73296e9d6611448
https://doi.org/10.2147/jpr.s131156
https://doi.org/10.2147/jpr.s131156