Mutations in dock1 disrupt early Schwann cell development

Autor: Rebecca L. Cunningham, Amy L. Herbert, Breanne L. Harty, Sarah D. Ackerman, Kelly R. Monk

Publikováno v: Neural Development, Vol 13, Iss 1, Pp 1-15 (2018)

Abstract Background In the peripheral nervous system (PNS), specialized glial cells called Schwann cells produce myelin, a lipid-rich insulating sheath that surrounds axons and promotes rapid action potential propagation. During development, Schwann

Externí odkaz: https://doaj.org/article/bc035e7148144a60af312c87db988eed

Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons

Autor: Catherine M Drerup, Amy L Herbert, Kelly R Monk, Alex V Nechiporuk

Publikováno v: eLife, Vol 6 (2017)

Mitochondrial transport in axons is critical for neural circuit health and function. While several proteins have been found that modulate bidirectional mitochondrial motility, factors that regulate unidirectional mitochondrial transport have been har

Externí odkaz: https://doaj.org/article/06bd23a1046a4def96486aa452e2a301

Evolution of stickleback spines through independent cis-regulatory changes at HOXDB

Autor: Julia I. Wucherpfennig, Timothy R. Howes, Jessica N. Au, Eric H. Au, Garrett A. Roberts Kingman, Shannon D. Brady, Amy L. Herbert, Thomas E. Reimchen, Michael A. Bell, Craig B. Lowe, Anne C. Dalziel, David M. Kingsley

Publikováno v: Nature ecologyevolution. 6(10)

Understanding the mechanisms leading to new traits or additional features in organisms is a fundamental goal of evolutionary biology. We show that HOXDB regulatory changes have been used repeatedly in different fish genera to alter the length and num

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57012d5b88600494a722dee143dfa2bc
https://pubmed.ncbi.nlm.nih.gov/36050398

Whole Genome Sequencing-Based Mapping and Candidate Identification of Mutations from Fixed Zebrafish Tissue

Autor: Sarah D. Ackerman, Ryan S. Gray, Breanne L. Harty, Nicholas E. Sanchez, Melanie Holmgren, Thomas O'Reilly-Pol, Stephen L. Johnson, Amy L. Herbert, Kelly R. Monk

Publikováno v: G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 7, Iss 10, Pp 3415-3425 (2017)

As forward genetic screens in zebrafish become more common, the number of mutants that cannot be identified by gross morphology or through transgenic approaches, such as many nervous system defects, has also increased. Screening for these difficult-t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::262e2982abd32f3e98cb3a07fa09de35
https://doi.org/10.1534/g3.117.300212

Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7

Autor: Amy L. Herbert, Breanne L. Harty, Kelly R. Monk, Fernanda Coelho, Jonah R. Chan, David A. Lyons, Judith P. Golden, Sarah D. Ackerman, Amit Mogha, Sarah E. Pease-Raissi, Robert W. Gereau

Publikováno v: Harty, B L, Coelho, F, Pease-Raissi, S E, Mogha, A, Ackerman, S D, Herbert, A L, Gereau IV, R W, Golden, J P, Lyons, D A, Chan, J R & Monk, K R 2019, ' Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7 ', Nature Communications, vol. 10, 2976 . https://doi.org/10.1038/s41467-019-10881-y
Nature communications, vol 10, iss 1
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

In the central nervous system (CNS), oligodendrocytes myelinate multiple axons; in the peripheral nervous system (PNS), Schwann cells (SCs) myelinate a single axon. Why are the myelinating potentials of these glia so fundamentally different? Here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a67c8387cf7472260841b09e32cdc8d4
https://www.pure.ed.ac.uk/ws/files/122600066/s41467_019_10881_y.pdf