Zobrazeno 1 - 10 of 46 pro vyhledávání: '"Amy L Williams"'
1
Akademický článek
Evaluating the utility of identity-by-descent segment numbers for relatedness inference via information theory and classification
Autor: Jesse Smith, Ying Qiao, Amy L Williams
Publikováno v: G3: Genes, Genomes, Genetics, Vol 12, Iss 6 (2022)
AbstractDespite decades of methods development for classifying relatives in genetic studies, pairwise relatedness methods’ recalls are above 90% only for first through third-degree relatives. The top-performing approaches, which leverage identity-b
Externí odkaz: https://doaj.org/article/a49449e89df246429f73e2daf6693a75
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2
Akademický článek
Sexual dimorphism and the effect of wild introgressions on recombination in cassava (Manihot esculenta Crantz) breeding germplasm
Autor: Ariel W Chan, Seren S Villwock, Amy L Williams, Jean-Luc Jannink
Publikováno v: G3: Genes, Genomes, Genetics, Vol 12, Iss 1 (2021)
AbstractRecombination has essential functions in meiosis, evolution, and breeding. The frequency and distribution of crossovers dictate the generation of new allele combinations and can vary across species and between sexes. Here, we examine recombin
Externí odkaz: https://doaj.org/article/8ab330547b5d48a1bcf4acf7b0d7fc1c
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3
Akademický článek
Mapping gene flow between ancient hominins through demography-aware inference of the ancestral recombination graph.
Autor: Melissa J Hubisz, Amy L Williams, Adam Siepel
Publikováno v: PLoS Genetics, Vol 16, Iss 8, p e1008895 (2020)
The sequencing of Neanderthal and Denisovan genomes has yielded many new insights about interbreeding events between extinct hominins and the ancestors of modern humans. While much attention has been paid to the relatively recent gene flow from Neand
Externí odkaz: https://doaj.org/article/3174cc3b18664bd5b3a2c4350bedb063
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4
Akademický článek
Crossover interference and sex-specific genetic maps shape identical by descent sharing in close relatives.
Autor: Madison Caballero, Daniel N Seidman, Ying Qiao, Jens Sannerud, Thomas D Dyer, Donna M Lehman, Joanne E Curran, Ravindranath Duggirala, John Blangero, Shai Carmi, Amy L Williams
Publikováno v: PLoS Genetics, Vol 15, Iss 12, p e1007979 (2019)
Simulations of close relatives and identical by descent (IBD) segments are common in genetic studies, yet most past efforts have utilized sex averaged genetic maps and ignored crossover interference, thus omitting features known to affect the breakpo
Externí odkaz: https://doaj.org/article/be224e2351de4e08be3c91ba89310c9f
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5
Akademický článek
Non-crossover gene conversions show strong GC bias and unexpected clustering in humans
Autor: Amy L Williams, Giulio Genovese, Thomas Dyer, Nicolas Altemose, Katherine Truax, Goo Jun, Nick Patterson, Simon R Myers, Joanne E Curran, Ravi Duggirala, John Blangero, David Reich, Molly Przeworski, on behalf of the T2D-GENES Consortium
Publikováno v: eLife, Vol 4 (2015)
Although the past decade has seen tremendous progress in our understanding of fine-scale recombination, little is known about non-crossover (NCO) gene conversion. We report the first genome-wide study of NCO events in humans. Using SNP array data fro
Externí odkaz: https://doaj.org/article/16ae6f379cf3443e882d52a9a291051f
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7
Haptools: a toolkit for admixture and haplotype analysis
Autor: Arya R Massarat, Michael Lamkin, Ciara Reeve, Amy L Williams, Matteo D’Antonio, Melissa Gymrek
Publikováno v: Bioinformatics. 39
SummaryLeveraging local ancestry and haplotype information in genome-wide association studies and downstream analyses can improve the utility of genomics for individuals from diverse and recently admixed ancestries. However, most existing simulation,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72ca122a5abcec587d1090bb91df8dba
https://doi.org/10.1093/bioinformatics/btad104
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8
Patterns of genetic connectedness between modern and medieval Estonian genomes reveal the origins of a major ancestry component of the Finnish population
Autor: Ene Metspalu, Ruoyun Hui, Siiri Rootsi, Lehti Saag, Simone Andrea Biagini, Kadri Irdt, Lauri Saag, Eugenia D’Atanasio, Luca Pagani, Mait Metspalu, Tuuli Reisberg, Amy L. Williams, Christiana L. Scheib, Reedik Mägi, Daniel N. Seidman, Toomas Kivisild, Anu Solnik, Heiki Valk, Martin Malve, Vasili Pankratov, Kristiina Tambets
Publikováno v: American journal of human genetics 108 (2021): 1792–1806. doi:10.1016/j.ajhg.2021.07.012
info:cnr-pdr/source/autori:Kivisild, Toomas; Saag, Lehti; Hui, Ruoyun; Biagini, Simone Andrea; Pankratov, Vasili; D'Atanasio, Eugenia; Pagani, Luca; Saag, Lauri; Rootsi, Siiri; Mägi, Reedik; Metspalu, Ene; Valk, Heiki; Malve, Martin; Irdt, Kadri; Reisberg, Tuuli; Solnik, Anu; Scheib, Christiana L.; Seidman, Daniel N.; Williams, Amy L.; Tambets, Kristiina; Metspalu, Mait/titolo:Patterns of genetic connectedness between modern and medieval Estonian genomes reveal the origins of a major ancestry component of the Finnish population/doi:10.1016%2Fj.ajhg.2021.07.012/rivista:American journal of human genetics/anno:2021/pagina_da:1792/pagina_a:1806/intervallo_pagine:1792–1806/volume:108
Am J Hum Genet
The Finnish population is a unique example of a genetic isolate affected by a recent founder event. Previous studies have suggested that the ancestors of Finnic-speaking Finns and Estonians reached the circum-Baltic region by the 1(st) millennium BC.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d49f3ecbdd8160f2691ab8791127ce7
https://doi.org/10.1016/j.ajhg.2021.07.012
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9
Simultaneous inference of parental admixture proportions and admixture times from unphased local ancestry calls
Autor: Siddharth Avadhanam, Amy L. Williams
Publikováno v: Am J Hum Genet
Population genetic analyses of local ancestry tracts routinely assume that the ancestral admixture process is identical for both parents of an individual, an assumption that may be invalid when considering recent admixture. Here we present Parental A
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02598c8de24657191f7bb58df114d6c
https://europepmc.org/articles/PMC9388397/
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10
Evaluating the utility of identity-by-descent segment numbers for relatedness inference via information theory and classification
Autor: Ying Qiao, Amy L. Williams, Jesse Smith
Publikováno v: G3 Genes|Genomes|Genetics. 12
Despite decades of methods development for classifying relatives in genetic studies, pairwise relatedness methods’ recalls are above 90% only for first through third-degree relatives. The top-performing approaches, which leverage identity-by-descen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8087083caeeae6cb3c206c2cd934b43b
https://doi.org/10.1093/g3journal/jkac072
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