Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Amy L Myers"'
Autor:
Samuel A Kerk, Lin Lin, Amy L Myers, Damien J Sutton, Anthony Andren, Peter Sajjakulnukit, Li Zhang, Yaqing Zhang, Jennifer A Jiménez, Barbara S Nelson, Brandon Chen, Anthony Robinson, Galloway Thurston, Samantha B Kemp, Nina G Steele, Megan T Hoffman, Hui-Ju Wen, Daniel Long, Sarah E Ackenhusen, Johanna Ramos, Xiaohua Gao, Zeribe C Nwosu, Stefanie Galban, Christopher J Halbrook, David B Lombard, David R Piwnica-Worms, Haoqiang Ying, Marina Pasca di Magliano, Howard C Crawford, Yatrik M Shah, Costas A Lyssiotis
Publikováno v:
eLife, Vol 11 (2022)
Mitochondrial glutamate-oxaloacetate transaminase 2 (GOT2) is part of the malate-aspartate shuttle, a mechanism by which cells transfer reducing equivalents from the cytosol to the mitochondria. GOT2 is a key component of mutant KRAS (KRAS*)-mediated
Externí odkaz:
https://doaj.org/article/3f6b7faa3ebf44d494617d12f6cd6c1c
Autor:
Nneka E. Mbah, Amy L. Myers, Peter Sajjakulnukit, Chan Chung, Joyce K. Thompson, Hanna S. Hong, Heather Giza, Derek Dang, Zeribe C. Nwosu, Mengrou Shan, Stefan R. Sweha, Daniella D. Maydan, Brandon Chen, Li Zhang, Brian Magnuson, Zirui Zhu, Megan Radyk, Brooke Lavoie, Viveka Nand Yadav, Imhoi Koo, Andrew D. Patterson, Daniel R. Wahl, Luigi Franchi, Sameer Agnihotri, Carl J. Koschmann, Sriram Venneti, Costas A. Lyssiotis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract H3K27M diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), exhibit cellular heterogeneity comprising less-differentiated oligodendrocyte precursors (OPC)-like stem cells and more differentiated astrocyte (AC)-l
Externí odkaz:
https://doaj.org/article/b60128e341cf4e8c9deb69669f6c0187
Autor:
Samuel A Kerk, Lin Lin, Amy L Myers, Damien J Sutton, Anthony Andren, Peter Sajjakulnukit, Li Zhang, Yaqing Zhang, Jennifer A Jiménez, Barbara S Nelson, Brandon Chen, Anthony Robinson, Galloway Thurston, Samantha B Kemp, Nina G Steele, Megan T Hoffman, Hui-Ju Wen, Daniel Long, Sarah E Ackenhusen, Johanna Ramos, Xiaohua Gao, Zeribe C Nwosu, Stefanie Galban, Christopher J Halbrook, David B Lombard, David R Piwnica-Worms, Haoqiang Ying, Marina Pasca di Magliano, Howard C Crawford, Yatrik M Shah, Costas A Lyssiotis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c09d5546598866e76a5a9578902c0ae7
https://doi.org/10.7554/elife.73245.sa2
https://doi.org/10.7554/elife.73245.sa2
Autor:
Nneka E. Mbah, Amy L. Myers, Chan Chung, Joyce K. Thompson, Hanna S. Hong, Peter Sajjakulnukit, Zeribe C. Nwosu, Mengrou Shan, Stefan R. Sweha, Daniella D. Maydan, Brandon Chen, Li Zhang, Brian Magnuson, Zirui Zui, Daniel R. Wahl, Luigi Franchi, Sameer Agnihotri, Carl J. Koschmann, Sriram Venneti, Costas A. Lyssiotis
H3K27M diffuse intrinsic pontine gliomas (DIPG) exhibit cellular heterogeneity comprising less-differentiated, stem-like glioma cells that resemble oligodendrocyte precursors (OPC) and more differentiated astrocyte (AC)-like cells. H3K27M DIPG stem-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e09f2bbf821cb523eaab86fc14098b1
https://doi.org/10.1101/2022.03.01.482555
https://doi.org/10.1101/2022.03.01.482555
Autor:
Brandon Nicolay, Amy L. Myers, John M. Asara, Cecilia Cotta-Ramusino, Lin Lin, Johanna Ramos, Christopher J. Halbrook, Scott Campit, Ho-Joon Lee, Joseph Dresser, Alec C. Kimmelman, Ilya Kovalenko, Oksana Mashadova, Lewis C. Cantley, Tina Gao, Zeribe C. Nwosu, Costas A. Lyssiotis, Howard C. Crawford, Daniel R. Wahl, Zachary P. Tolstyka, Daniel M. Kremer, Barbara S. Nelson, Kari Wilder-Romans, Mary A. Davis, Cristovão M. Sousa, Sriram Chandrasekaran
Publikováno v:
Cancer & Metabolism, Vol 8, Iss 1, Pp 1-16 (2020)
Cancer & Metabolism
Cancer & Metabolism
Background Metabolic programs in cancer cells are influenced by genotype and the tissue of origin. We have previously shown that central carbon metabolism is rewired in pancreatic ductal adenocarcinoma (PDA) to support proliferation through a glutama
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75fddc60cfad376852390f945e41749d
https://doaj.org/article/e08285467c004f0193e607f0286f4ab7
https://doaj.org/article/e08285467c004f0193e607f0286f4ab7
Autor:
Nupur K. Das, Amy L. Myers, Costas A. Lyssiotis, Stephen A. Sastra, Li Zhang, Christopher J. Halbrook, Samuel K. McBrayer, Anthony Andren, Yatrik M. Shah, Michael A. Badgley, Marina Pasca di Magliano, Andrew C. Little, Daniel M. Kremer, John M. Asara, Lin Lin, Kenneth P. Olive, Emily L. Yarosz, Nneka E. Mbah, Milan R. Savani, Sean W. Hou, Nicholas Cusmano, Tina Gao, Zeribe C. Nwosu, Peter Sajjakulnukit, Carmine F. Palermo, Mengrou Shan, Johanna Ramos, Stephanie Wisner, Brian Magnuson, Barbara S. Nelson, Galloway Thurston, Eileen S. Carpenter, Howard C. Crawford, Samuel A. Kerk
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature communications, vol 12, iss 1
Nature Communications
Nature communications, vol 12, iss 1
Cancer metabolism is rewired to support cell survival in response to intrinsic and environmental stressors. Identification of strategies to target these adaptions is an area of active research. We previously described a cytosolic aspartate aminotrans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3357e197241e4b91f3d40aa8ef2076
https://doi.org/10.1038/s41467-021-24859-2
https://doi.org/10.1038/s41467-021-24859-2
Autor:
Marina Pasca di Magliano, Yatrik M. Shah, David B. Lombard, Peter Sajjakulnukit, Stefanie Galbán, Barbara S. Nelson, Amy L. Myers, Sarah E. Ackenhusen, Xiaohua Gao, Zeribe C. Nwosu, Yaqing Zhang, Howard C. Crawford, Christopher J. Halbrook, Jennifer A. Jiménez, Hui-Ju Wen, Lin Lin, David Piwnica-Worms, Samuel A. Kerk, Brandon Chen, Anthony Robinson, Megan T. Hoffman, Li Zhang, Johanna Ramos, Anthony Andren, Nina Steele, Haoqiang Ying, Daniel Long, Galloway Thurston, Samantha Kemp, Costas A. Lyssiotis
The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDA) restricts vascularization and, consequently, access to blood-derived nutrients and oxygen, which impacts tumor growth. Intracellular redox imbalance is another restraint on ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95687ad2e7dbe8eedc6f2a8dbe37ad5e
https://doi.org/10.1101/2020.08.07.238766
https://doi.org/10.1101/2020.08.07.238766
Autor:
Carmine F. Palermo, Christopher J. Halbrook, Daniel M. Kremer, Stephen A. Sastra, Peter Sajjakulnukit, Marina Pasca di Magliano, Yatrik M. Shah, Li Zhang, Sean W. Hou, Samuel A. Kerk, Anthony Andren, Johanna Ramos, Nicholas Cusmano, John M. Asara, Lin Lin, Tina Gao, Costas A. Lyssiotis, Kenneth P. Olive, Zeribe C. Nwosu, Emily L. Yarosz, Galloway Thurston, Eileen S. Carpenter, Amy L. Myers, Howard C. Crawford, Michael A. Badgley, Stephanie Wisner, Barbara S. Nelson
SummaryPancreatic ductal adenocarcinoma (PDA) is one of the deadliest solid malignancies, with a 5-year survival rate at ten percent. PDA have unique metabolic adaptations in response to cell-intrinsic and environmental stressors, and identifying new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8eb8c538b9e758b6b27da0acc88e761
Autor:
Joyce K. Thompson, Hanna Hong, Sriram Venneti, Costas A. Lyssiotis, Carl Koschmann, Mengrou Shan, Nneka E. Mbah, Amy L. Myers, Chan Chung
Publikováno v:
Neuro-oncology Advances
BACKGROUND Diffuse Intrinsic Pontine Glioma (DIPG) is a uniformly fatal pediatric brainstem tumor and the leading cause of brain-tumor related deaths in children. It is therefore imperative to identify novel treatment strategies for this aggressive a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e05ab4c3a6299e8eb65ea0ab75fabe67
https://doi.org/10.1093/noajnl/vdab024.052
https://doi.org/10.1093/noajnl/vdab024.052
Autor:
Dafydd G. Thomas, Lin Lin, Mark B. Orringer, Derek J. Nancarrow, Amy L. Myers, Jules Lin, Zhuwen Wang, Andrew C. Chang, David G. Beer, Rishindra M. Reddy, Daysha Ferrer-Torres
Publikováno v:
Oncotarget
Esophageal adenocarcinoma (EAC) patients commonly present with advanced stage disease and demonstrate resistance to therapy, with response rates below 40%. Understanding the molecular mechanisms of resistance is crucial for improvement of clinical ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf823431947ab555e35b6b03a01126ce
http://europepmc.org/articles/PMC4694874
http://europepmc.org/articles/PMC4694874