Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Amy L Brittle"'
Publikováno v:
eLife, Vol 4 (2015)
To understand how long-range patterning gradients are interpreted at the cellular level, we investigate how a gradient of expression of the Four-jointed kinase specifies planar polarised distributions of the cadherins Fat and Dachsous in the Drosophi
Externí odkaz:
https://doaj.org/article/ead8554ac2c949d383dfbc35633341cc
Autor:
Emma Louise Armitage, Martin P. Zeidler, Iwan Robert Evans, Elliot Brooks, Amy L Brittle, Jonathon Alexis Coates
Publikováno v:
eLife, Vol 10 (2021)
Vertebrate macrophages are a highly heterogeneous cell population, but whileDrosophilablood is dominated by a macrophage-like lineage (plasmatocytes), until very recently these cells were considered to represent a homogeneous population. Here, we pre
Publikováno v:
Current Biology
Summary Two pathways regulate planar polarity: the core proteins and the Fat-Dachsous-Four-jointed (Ft-Ds-Fj) system. Morphogens specify complementary expression patterns of Ds and Fj that potentially act as polarizing cues. It has been suggested tha
Publikováno v:
Experimental Cell Research
The spatial and temporal control of histone modifications is crucial for precise regulation of chromatin structure and function. Here we report that phosphorylation of H2A at threonine 119 (T119) is enriched at centromere regions in Drosophila mitosi
Publikováno v:
eLife, Vol 4 (2015)
To understand how long-range patterning gradients are interpreted at the cellular level, we investigate how a gradient of expression of the Four-jointed kinase specifies planar polarised distributions of the cadherins Fat and Dachsous in the Drosophi
Dual roles of Incenp crucial to the assembly of the acentrosomal metaphase spindle in female meiosis
Autor:
Mar Carmena, Janet K. Jang, Hiroyuki Ohkura, Kim S. McKim, C. Fiona Cullen, Nathalie Colombié, William C. Earnshaw, Amy L. Brittle
Publikováno v:
Colombie, N, Cullen, F, Brittle, A, Jang, J, Earnshaw, B, Carmena, M, McKim, K & Ohkura, H 2008, ' Dual roles of Incenp crucial to the assembly of the acentrosomal metaphase spindle in female meiosis ', Development, vol. 135, no. 19, pp. 3239-3246 . https://doi.org/10.1242/dev.022624
Spindle formation in female meiosis differs from mitosis in many animals,as it takes place independently of centrosomes, and the molecular requirements of this pathway remain to be understood. Here, we report two crucial roles of Incenp, an essential
Publikováno v:
The Journal of Cell Biology
Conventional centrosomes are absent from the spindle in female meiosis in many species, but it is not clear how multiple chromosomes form one shared bipolar spindle without centrosomes. We identified a female sterile mutant in which each bivalent chr
Autor:
Amy L. Brittle, Hiroyuki Ohkura
Publikováno v:
The EMBO journal. 24(7)
Drosophila Mini spindles (Msps) protein belongs to a conserved family of microtubule-associated proteins (MAPs). Intriguingly, this family of MAPs, including Xenopus XMAP215, was reported to have both microtubule stabilising and destabilising activit