Výsledky vyhledávání - "Amy K. M. Lam"

Akademický článek

Selective over-expression of endothelin-1 in endothelial cells exacerbates inner retinal edema and neuronal death in ischemic retina.

Autor: Simon S F Cheung, Justin W C Leung, Amy K M Lam, Karen S L Lam, Stephen S M Chung, Amy C Y Lo, Sookja K Chung

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e26184 (2011)

The level of endothelin-1 (ET-1), a potent vasoconstrictor, was associated with retinopathy under ischemia. The effects of endothelial endothelin-1 (ET-1) over-expression in a transgenic mouse model using Tie-1 promoter (TET-1 mice) on pathophysiolog

Externí odkaz: https://doaj.org/article/60d5910b984c4c61a38ac03e06f53834

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Exchange protein activated by cAMP 1(Epac1)‐deficient mice develop β‐cell dysfunction and metabolic syndrome

Autor: Xinmei Zhang, Stephen S.M. Chung, Andrew C. P. Tai, Sookja K. Chung, Aimin Xu, Alan K. L. Kai, Angela K. W. Lai, Patrick Ka Kit Yeung, Karen S. Lam, Jian Wang, Sidney Tam, Amy K. M. Lam, Paul M. Vanhoutte, Ying Xian Chen, Johannes L. Bos

Publikováno v: The FASEB Journal. 27:4122-4135

Previously, exchange protein directly activated by cAMP 2 (Epac2) and PKA were known to play a role in glucose-stimulated insulin secretion (GSIS) by pancreatic β cells. The present study shows that Epac1 mRNA is also expressed by β cells. Therefor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a1bfc4e54f13c7a3dd2ee928f341df
https://doi.org/10.1096/fj.13-230433

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Osmotic Response Element-binding Protein (OREBP) Is an Essential Regulator of the Urine Concentrating Mechanism

Autor: Ryan G. Morris, Amy K. M. Lam, Sidney Tam, Sookja K. Chung, Ben C.B. Ko, James Y. Yang, Stephen S.M. Chung

Publikováno v: Journal of Biological Chemistry. 279:48048-48054

OREBP (osmotic response element-binding protein), also called TonEBP or NFAT5, is thought to induce the expression of genes that increase the accumulation of organic osmolytes to protect cells against a hypertonic environment. To investigate the cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db91bb2e081ee9b49db25f549b93a0e4
https://doi.org/10.1074/jbc.m407224200

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Selective over-expression of endothelin-1 in endothelial cells exacerbates inner retinal edema and neuronal death in ischemic retina

Autor: Justin W.C. Leung, Amy C. Y. Lo, Karen S.L. Lam, Amy K. M. Lam, Sookja K. Chung, Stephen S.M. Chung, Simon S. F. Cheung

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e26184 (2011)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d424982642a05751466746bd0898d2df
http://europepmc.org/articles/PMC3203861?pdf=render

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Deleted in liver cancer 2 (DLC2) was dispensable for development and its deficiency did not aggravate hepatocarcinogenesis

Autor: Amy K. M. Lam, Irene Oi-Lin Ng, Sandra Lam, Sookja K. Chung, Edmund Kwok-Kwan Tung, Tai-On Yau, Oi Fung Cheung, Thomas Ho-Yin Leung, Pek-Lan Khong

Publikováno v: PLoS ONE, Vol 4, Iss 8, p e6566 (2009)
PLoS ONE

DLC2 (deleted in liver cancer 2), a Rho GTPase-activating protein, was previously shown to be underexpressed in human hepatocellular carcinoma and has tumor suppressor functions in cell culture models. We generated DLC2-deficient mice to investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7468375363ead22fe8caf3fee477587
http://hdl.handle.net/10722/67503

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Phenotypes developed in secretin receptor-null mice indicated a role for secretin in regulating renal water reabsorption

Autor: Sookja K. Chung, Sidney Tam, Samuel C. K. Chung, Amy K. M. Lam, Billy K. C. Chow, Jessica Y. S. Chu

Aquaporin 2 (AQP2) is responsible for regulating the concentration of urine in the collecting tubules of the kidney under the control of vasopressin (Vp). Studies using Vp-deficient Brattleboro rats, however, indicated the existence of substantial Vp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503c55c8bb99fff21d4e0a8b3905ce14
http://hdl.handle.net/10722/67894

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Fyn and p38 signaling are both required for maximal hypertonic activation of the osmotic response element-binding protein/tonicity-responsive enhancer-binding protein (OREBP/TonEBP)

Autor: Sookja K. Chung, Ben C.B. Ko, Amy K. M. Lam, Lingzhi Fan, Stephen S.M. Chung, Andras Kapus

Publikováno v: The Journal of biological chemistry. 277(48)

When cells are challenged by hyperosmotic stress, one of the crucial adaptive responses is the expression of osmoprotective genes that are responsible for raising the intracellular level of compatible osmolytes such as sorbitol, betaine, and myo-inos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9572a7e6113f52739fef271a22f09fa0
https://pubmed.ncbi.nlm.nih.gov/12359721

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