Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Amy K Sheaffer"'
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Akademický článek
A Small Molecule Inhibitor Selectively Induces Apoptosis in Cells Transformed by High Risk Human Papilloma Viruses.
Autor: Amy K Sheaffer, Min S Lee, Huilin Qi, Susan Chaniewski, Xiaofan Zheng, Glen A Farr, Kim Esposito, David Harden, Ming Lei, Liang Schweizer, Jacques Friborg, Michele Agler, Fiona McPhee, Robert Gentles, Brett R Beno, Lou Chupak, Stephen Mason
Publikováno v: PLoS ONE, Vol 11, Iss 6, p e0155909 (2016)
A phenotypic high-throughput cell culture screen was performed to identify compounds that prevented proliferation of the human Papilloma virus type 16 (HPV-16) transformed cell line Ca Ski. A series of quinoxaline compounds exemplified by Compound 1
Externí odkaz: https://doaj.org/article/0b210787c3874e4696b86d353003b927
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5
Combinations of Lambda Interferon with Direct-Acting Antiviral Agents Are Highly Efficient in Suppressing Hepatitis C Virus Replication
Autor: Amy K. Sheaffer, Steven Levine, Voss Stacey A, Fiona McPhee, Julie A. Lemm, Chaoqun Chen, Susan Chaniewski, Jacques Friborg
Publikováno v: Antimicrobial Agents and Chemotherapy. 57:1312-1322
The clinical efficacy of a pegylated form of human lambda 1 interferon (IFN-λ1; also referred to herein as lambda) has been demonstrated in patients chronically infected with hepatitis C virus (HCV) representing genotypes 1 through 4. In these proof
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a609b5c5c01007aea8231684fe684b
https://doi.org/10.1128/aac.02239-12
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6
Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing
Autor: Huabin Sun, Hua Fang, Richard Rampulla, Alan Xiangdong Wang, Bilder Donna M, Bang-Chi Chen, Zhao Qian, Chaoqun Chen, Brian Lee Venables, Fiona McPhee, Jie Chen, Maria Donoso, Barbara Zheng, Paul Falk, Ying-Kai Wang, Yan Chen, Nicholas A. Meanwell, Yong-Hae Han, Qi Gao, Richard Schartman, Luciano Mueller, Steven Levine, Herbert E. Klei, Jacques Friborg, Stephen P. Adams, Ramkumar Rajamani, Anthony J. Cocuzza, Theerthagiri Palani, Dennis M. Grasela, Dennis Hernandez, Fei Yu, Sivakumar Ganesan, James Loy, Tatyana Zvyaga, Paul Levesque, Li-Qiang Sun, Amy K. Sheaffer, Eric Mull, Arvind Mathur, Kathy Mosure, Jeffrey Tredup, Stanley D'andrea, Pirama Nayagam Arunachalam, Jialong Zhu, Mark I. Cockett, Hong Shi, Sing-Yuen Sit, Ny Sin, Paul Michael Scola, Jay O. Knipe, Alicia Ng, William Warner, Kevin Kish, Lucy Sun, Michael Sinz, Danshi Li
Publikováno v: Journal of medicinal chemistry. 59(17)
The discovery of a back-up to the hepatitis C virus NS3 protease inhibitor asunaprevir (2) is described. The objective of this work was the identification of a drug with antiviral properties and toxicology parameters similar to 2, but with a preclini
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd2d8cdbd5956b1b7c966304767a031
https://pubmed.ncbi.nlm.nih.gov/27564532
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7
Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032)
Autor: Min S. Lee, Steven Levine, Richard J. Colonno, Kathy Mosure, Paul Michael Scola, Nicholas A. Meanwell, Chaoqun Chen, Michael Sinz, Li-Qiang Sun, Susan Chaniewski, Fiona McPhee, Paul Falk, Jacques Friborg, Fei Yu, Diana Barry, Dennis Hernandez, Amy K. Sheaffer, Guangzhi Zhai, Jay O. Knipe
Publikováno v: Antimicrobial Agents and Chemotherapy. 56:5387-5396
Asunaprevir (ASV; BMS-650032) is a hepatitis C virus (HCV) NS3 protease inhibitor that has demonstrated efficacy in patients chronically infected with HCV genotype 1 when combined with alfa interferon and/or the NS5A replication complex inhibitor dac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e65c6b8abe684c71c75d15ec47f42e
https://doi.org/10.1128/aac.01186-12
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8
Resistance Analysis of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir
Autor: Dennis Hernandez, Amy K. Sheaffer, Fei Yu, Jacques Friborg, Fiona McPhee, Chaoqun Chen, Claudio Pasquinelli, Susan Chaniewski, Paul Falk, Min S. Lee, Steven Levine
Publikováno v: Antimicrobial Agents and Chemotherapy. 56:3670-3681
Asunaprevir (BMS-650032) is a potent hepatitis C virus (HCV) NS3 protease inhibitor demonstrating efficacy in alfa interferon-sparing, direct-acting antiviral dual-combination regimens (together with the NS5A replication complex inhibitor daclatasvir
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e52d6023215dace04e2d0a7e5ab1e3d7
https://doi.org/10.1128/aac.00308-12
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10
A Small Molecule Inhibitor Selectively Induces Apoptosis in Cells Transformed by High Risk Human Papilloma Viruses
Autor: Amy K. Sheaffer, Glen A. Farr, Min S. Lee, Lou Chupak, Liang Schweizer, Ming Lei, Stephen W. Mason, Kim Esposito, Susan Chaniewski, David G. Harden, Xiaofan Zheng, Brett R. Beno, Huilin Qi, Fiona McPhee, Michele Agler, Robert G. Gentles, Jacques Friborg
Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 6, p e0155909 (2016)
A phenotypic high-throughput cell culture screen was performed to identify compounds that prevented proliferation of the human Papilloma virus type 16 (HPV-16) transformed cell line Ca Ski. A series of quinoxaline compounds exemplified by Compound 1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f38cd5ec3ffde81d78ca094fe46b94a
https://pubmed.ncbi.nlm.nih.gov/27280728
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