Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Amy K, Walker"'
Autor:
Kellianne D. Alexander, Shankar Ramachandran, Kasturi Biswas, Christopher M. Lambert, Julia Russell, Devyn B. Oliver, William Armstrong, Monika Rettler, Samuel Liu, Maria Doitsidou, Claire Bénard, Amy K. Walker, Michael M. Francis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract The elimination of synapses during circuit remodeling is critical for brain maturation; however, the molecular mechanisms directing synapse elimination and its timing remain elusive. We show that the transcriptional regulator DVE-1, which sh
Externí odkaz:
https://doaj.org/article/c7291b7359984983af968c801fae080e
Autor:
Adwait A Godbole, Sneha Gopalan, Thien-Kim Nguyen, Alexander L Munden, Dominique S Lui, Matthew J Fanelli, Paula Vo, Caroline A Lewis, Jessica B Spinelli, Thomas G Fazzio, Amy K Walker
Publikováno v:
eLife, Vol 12 (2023)
Methylation is a widely occurring modification that requires the methyl donor S-adenosylmethionine (SAM) and acts in regulation of gene expression and other processes. SAM is synthesized from methionine, which is imported or generated through the 1-c
Externí odkaz:
https://doaj.org/article/8ef70ae4ac0b4ed6b07168ee56561b9a
Autor:
Lorissa J. Smulan, Wei Ding, Elizaveta Freinkman, Sharvari Gujja, Yvonne J.K. Edwards, Amy K. Walker
Publikováno v:
Cell Reports, Vol 16, Iss 1, Pp 9-18 (2016)
Lipogenesis requires coordinated expression of genes for fatty acid, phospholipid, and triglyceride synthesis. Transcription factors, such as SREBP-1 (Sterol regulatory element binding protein), may be activated in response to feedback mechanisms lin
Externí odkaz:
https://doaj.org/article/af14761a8492452b8f2f4eec46547dda
Autor:
Adwait A Godbole, Sneha Gopalan, Thien-Kim Nguyen, Alexander L Munden, Dominique S Lui, Matthew J Fanelli, Paula Vo, Caroline A Lewis, Jessica B Spinelli, Thomas G Fazzio, Amy K Walker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dada2e2413ba5997c0fadbb02b71e809
https://doi.org/10.7554/elife.79511.sa2
https://doi.org/10.7554/elife.79511.sa2
Autor:
Wei Ding, Daniel P Higgins, Dilip K Yadav, Adwait A Godbole, Read Pukkila-Worley, Amy K Walker
Publikováno v:
PLoS Genetics, Vol 14, Iss 11, p e1007812 (2018)
S-adenosylmethionine (SAM) is a donor which provides the methyl groups for histone or nucleic acid modification and phosphatidylcholine production. SAM is hypothesized to link metabolism and chromatin modification, however, its role in acute gene reg
Externí odkaz:
https://doaj.org/article/1ae22b80007049538872d0791c023e2e
Publikováno v:
Genetics. 221
Omics tools provide broad datasets for biological discovery. However, the computational tools for identifying important genes or pathways in RNA-seq, proteomics, or GWAS (Genome-Wide Association Study) data depend on Gene Ontogeny annotations and are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32aed1391126414428b5fefd2a29d21
https://doi.org/10.1093/genetics/iyac085
https://doi.org/10.1093/genetics/iyac085
Autor:
Adwait A. Godbole, Sneha Gopalan, Thien-Kim Nguyen, Alexander Munden, Paula Vo, Caroline A. Lewis, Jessica B. Spinelli, Thomas G. Fazzio, Amy K. Walker
Methylation is a widely occurring modification that requires the methyl donor S-adenosylmethionine (SAM) and acts in regulation of gene expression and other processes. SAM is synthesized from methionine, which is imported or generated through the 1-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd8172b22e78fad0c43fade6b26124eb
https://doi.org/10.1101/2022.03.30.486419
https://doi.org/10.1101/2022.03.30.486419
Immunity-linked genes (ILGs) are activated by pathogens but also may respond to imbalances in lipids. Why pathogen attack and metabolic changes both impact ILG activation is unclear. We find that ILGs are activated when membrane phosphatidylcholine r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39017335ef92e06364bd861e7b8ce1a9
https://doi.org/10.1101/2021.11.16.468795
https://doi.org/10.1101/2021.11.16.468795
Genome-wide measurement of mRNA or protein levels provides broad data sets for biological discovery. However, subsequent computational methods are essential for uncovering the functional implications of the data as well as intuitively visualizing the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d077324fbfb8378a4e8fc4dfc3ce60d
https://doi.org/10.1101/2021.11.11.467968
https://doi.org/10.1101/2021.11.11.467968
WormCat: an online tool for annotation and visualization of Caenorhabditis elegans genome-scale data
Autor:
Albertha J.M. Walhout, Anne C. Hart, Peter R. Boag, Amy D. Holdorf, Daniel P Higgins, Gregory J. Pazour, Amy K. Walker
Publikováno v:
Genetics
The emergence of large gene expression datasets has revealed the need for improved tools to identify enriched gene categories and visualize enrichment patterns. While gene ontogeny (GO) provides a valuable tool for gene set enrichment analysis, it ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf3c9c5735fc35a82770c6b5b8162de
https://doi.org/10.1101/844928
https://doi.org/10.1101/844928