Mutant resources for functional genomics in Dictyostelium discoideum using REMI-seq technology

Autor: Christopher R. L. Thompson, Chris Brimson, Balint Stewart, Thomas Keller, Katie Parkinson, Robert Baines, Jason B. Wolf, Sarah Jaques, William M. Salvidge, Nicole Gruenheit, Amy Joy Baldwin, Rex L. Chisholm, Adrian J. Harwood

Publikováno v: BMC Biology
BMC Biology, Vol 19, Iss 1, Pp 1-19 (2021)

Background Genomes can be sequenced with relative ease, but ascribing gene function remains a major challenge. Genetically tractable model systems are crucial to meet this challenge. One powerful model is the social amoeba Dictyostelium discoideum, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2e894e3e120921d2a35580eec4be91
http://europepmc.org/articles/PMC8386026

A new mechanism for Cannabidiol in regulating the one-carbon cycle and methionine levels in Dictyostelium and in mammalian epilepsy models

Autor: Nicholas D. E. Greene, Joseph Damstra-Oddy, Joanna Boberska, Robert J. Harvey, Paul Finch, Amy Joy Baldwin, Christopher J. Perry, Christopher R. L. Thompson, Fabiana Piscitelli, Adrian J. Harwood, Kit-Yi Leung, Eleanor C. Warren, Robin S.B. Williams, Benjamin J. Whalley, Balint Stewart, Alister J. McNeish, Annette Müller-Taubenberger, Claire M. Williams, Devdutt Sharma, Sarah Glyn, Sandrine P. Claus, Pabitra Hriday Patra

Publikováno v: British journal of pharmacology (Online) (2020).
info:cnr-pdr/source/autori:Perry CJ, Finch P, Müller-Taubenberger A, Leung KY, Warren EC, Damstra-Oddy J, Sharma D, Patra PH, Glyn S, Boberska J, Stewart B, Baldwin A, Piscitelli F, Harvey RJ, Harwood A, Thompson C, Claus S, Greene NDE, McNeish A, Williams CM, Whalley BJ, Williams RSB./titolo:A new mechanism for Cannabidiol in regulating the one-carbon cycle and methionine levels in Dictyostelium and in mammalian epilepsy models./doi:/rivista:British journal of pharmacology (Online)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume
Perry, C J, Finch, P, Müller-Taubenberger, A, Leung, K-Y, Warren, E C, Damstra-Oddy, J, Sharma, D, Patra, P H, Glyn, S, Boberska, J, Stewart, B, Baldwin, A, Piscitelli, F, Harvey, R J, Harwood, A, Thompson, C, Claus, S, Greene, N D E, McNeish, A, Williams, C M, Whalley, B J & Williams, R S B 2019, ' A new mechanism for Cannabidiol in regulating the one-carbon cycle and methionine levels in Dictyostelium and in mammalian epilepsy models ', British Journal of Pharmacology . https://doi.org/10.1111/bph.14892
British Journal of Pharmacology

Background and Purpose: Epidiolex, a form of highly purified cannabidiol (CBD) derived from Cannabis plants has demonstrated seizure control activity in patients with Dravet syndrome, without a fully elucidated mechanism of action. We have employed a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a90729a06a68fac2f2a4686eb515dd
https://publications.cnr.it/doc/411516

Ubiquitin-dependent chloroplast-associated protein degradation in plants

Autor: R Paul Jarvis, Tijen Demiral Sert, Mats Töpel, Amy Joy Baldwin, Panagiotis Lymperopoulos, William J. Broad, Qihua Ling, Raphael Trösch

Publikováno v: Science. 363

Introduction Chloroplasts are plant organelles responsible for the bulk of terrestrial photosynthetic primary production. They evolved via endosymbiosis from a cyanobacterial organism more than a billion years ago. The biogenesis and operation of chl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69aeeaad41c71896411d72dea415da4b
https://doi.org/10.1126/science.aav4467

Cardiff sciSCREEN: A model for using film screenings to engage publics in university research

Autor: Amy Joy Baldwin, Susan Bisson, Luis Reyes-Galindo, Katie Lewis, Jamie Thornton Lewis

Publikováno v: Research for All (2017)

Cardiff sciSCREEN is a public engagement programme that brings together local experts and publics to discuss issues raised by contemporary cinema. Since 2010, Cardiff sciSCREEN (short for science on screen) has exhibited more than 50 films alongside

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b41c2edf84201268d199ba508210a1b9
https://www.scienceopen.com/document?vid=539c59b7-84cc-4d6e-bb1f-b2bd2e7d53cb

Regulation of β-Lactamase Activity by Remote Binding of Heme: Functional Coupling of Unrelated Proteins through Domain Insertion

Autor: Rudolf Konrad Allemann, D. Dafydd Jones, Abigail J. Williams, Josephine Lydia Morris, W. R. Edwards, Amy Joy Baldwin

Publikováno v: Biochemistry. 49:6541-6549

Coupling the activities of normally disparate proteins into one functional unit has significant potential in terms of constructing novel switching components for synthetic biology or as biosensors. It also provides a means of investigating the basis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::229cb91671001dbd5ac98702aab98259
https://doi.org/10.1021/bi100793y