Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Amy J. Turner"'
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 4, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/5b86d78c843c43108c539809f2da76de
Autor:
Amy J. Turner, Cyrine E. Haidar, Wenjian Yang, Erin C. Boone, Steven M. Offer, Philip E. Empey, Andrew Haddad, Saba Tahir, Gunter Scharer, Ulrich Broeckel, Andrea Gaedigk
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 1, Pp n/a-n/a (2024)
Abstract The DPYD gene encodes dihydropyrimidine dehydrogenase, the rate‐limiting enzyme for the metabolism of fluoropyrimidines 5‐fluorouracil and capecitabine. Genetic variants in DPYD have been associated with altered enzyme activity, therefor
Externí odkaz:
https://doaj.org/article/5ba0596362e44f6ea49932ac67879e47
Autor:
Amy J. Turner, Ashley D. Derezinski, Andrea Gaedigk, Mark E. Berres, David B. Gregornik, Keith Brown, Ulrich Broeckel, Gunter Scharer
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Complex regions in the human genome such as repeat motifs, pseudogenes and structural (SVs) and copy number variations (CNVs) present ongoing challenges to accurate genetic analysis, particularly for short-read Next-Generation-Sequencing (NGS) techno
Externí odkaz:
https://doaj.org/article/6fa0fec7755a47f89cb10893ddece312
Autor:
Wendy Y. Wang, David Twesigomwe, Charity Nofziger, Amy J. Turner, Lena-Sophie Helmecke, Ulrich Broeckel, Ashley D. Derezinski, Scott Hazelhurst, Andrea Gaedigk
Publikováno v:
Journal of Personalized Medicine, Vol 12, Iss 10, p 1575 (2022)
The CYP2D6 gene has been widely studied to characterize variants and/or star alleles, which account for a significant portion of variability in drug responses observed within and between populations. However, African populations remain under-represen
Externí odkaz:
https://doaj.org/article/a3fd1ede6e6948cc94b2ea0d48e61141
Autor:
Marguerite R. Irvin, Praful Aggarwal, Steven A. Claas, Lisa de las Fuentes, Anh N. Do, C. Charles Gu, Andrea Matter, Benjamin S. Olson, Amit Patki, Karen Schwander, Joshua D. Smith, Vinodh Srinivasasainagendra, Hemant K. Tiwari, Amy J. Turner, Deborah A. Nickerson, Dabeeru C. Rao, Ulrich Broeckel, Donna K. Arnett
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Background: Indices of left ventricular (LV) structure and geometry represent useful intermediate phenotypes related to LV hypertrophy (LVH), a predictor of cardiovascular (CV) disease (CVD) outcomes.Methods and Results: We conducted an exome-wide as
Externí odkaz:
https://doaj.org/article/0344524737714338964b8b800f9381b8
Autor:
Wendy Y, Wang, David, Twesigomwe, Charity, Nofziger, Amy J, Turner, Lena-Sophie, Helmecke, Ulrich, Broeckel, Ashley D, Derezinski, Scott, Hazelhurst, Andrea, Gaedigk
Publikováno v:
Journal of personalized medicine. 12(10)
The
Autor:
Charity Nofziger, Amy J. Turner, Katrin Sangkuhl, Michelle Whirl‐Carrillo, José A.G. Agúndez, John L. Black, Henry M. Dunnenberger, Gualberto Ruano, Martin A. Kennedy, Michael S. Phillips, Houda Hachad, Teri E. Klein, Andrea Gaedigk
Publikováno v:
Clin Pharmacol Ther
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism of numerous drugs and, thus, can impact drug efficacy and safety. This GeneFocu
Autor:
Lucie Costard, Sarah C. Sherwood, Martin A. Knoll, Christopher Van de Ven, Scott J. Torreano, Amy J. Turner, Donald B. Potter, Jeffrey G. Paine
Publikováno v:
Symposium on the Application of Geophysics to Engineering and Environmental Problems 2021.
Publikováno v:
Southeastern Naturalist. 18:130
As a non-invasive approach for sampling small mammals, track tubes may be especially useful in species occupancy studies that do not require marking of individuals. However, such studies may involve significant uncertainty in identifying many tracks
Autor:
Kristen A. Baltgalvis, Hanke Heun-Johnson, Kevin J. Sonnemann, Dawn A. Lowe, James M. Ervasti, Amy J. Turner
Publikováno v:
PLoS Medicine
PLoS Medicine, Vol 6, Iss 5, p e1000083 (2009)
PLoS Medicine, Vol 6, Iss 5, p e1000083 (2009)
James Ervasti and colleagues show that injection of a truncated form of utrophin transduced all tissues examined, integrated with members of the dystrophin complex, and reduced serum levels of creatine kinase in a mouse model of muscular dystrophy.