Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Amy J. Tibbo"'
Autor:
Amy J. Tibbo, George S. Baillie
Publikováno v:
Cells, Vol 9, Iss 5, p 1254 (2020)
Phosphodiesterases (PDEs) are the only superfamily of enzymes that have the ability to break down cyclic nucleotides and, as such, they have a pivotal role in neurological disease and brain development. PDEs have a modular structure that allows targe
Externí odkaz:
https://doaj.org/article/24b9674599d04346a1283f302b41796d
Autor:
Amy J. Tibbo, Andrew Hartley, Richa Vasan, Robin Shaw, Laura Galbraith, Ernest Mui, Hing Y. Leung, Imran Ahmad
Publikováno v:
British Journal of Cancer. 128:1991-1999
Background Prostate cancer is the most common cancer in men in the developed world, with most deaths caused by advanced and metastatic disease which has no curative options. Here, we identified Mbtps2 alteration to be associated with metastatic disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f66353566e1a41939505afbe1f3f3ddc
https://doi.org/10.1038/s41416-023-02237-7
https://doi.org/10.1038/s41416-023-02237-7
Autor:
Bracy, Fertig, Jiayue, Ling, Edgar E, Nollet, Sara, Dobi, Tara, Busiau, Kiyotake, Ishikawa, Kelly, Yamada, Ahyoung, Lee, Changwon, Kho, Lauren, Wills, Amy J, Tibbo, Mark, Scott, Kirsten, Grant, Kenneth S, Campbell, Emma J, Birks, Niall, MacQuaide, Roger, Hajjar, Godfrey L, Smith, Jolanda, van der Velden, George S, Baillie
Publikováno v:
The FEBS journal. 289(20)
Post-translational modification of the myofilament protein troponin I by phosphorylation is known to trigger functional changes that support enhanced contraction and relaxation of the heart. We report for the first time that human troponin I can also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2a963182ab602f3d02da63c30a7daf88
https://pubmed.ncbi.nlm.nih.gov/35633070
https://pubmed.ncbi.nlm.nih.gov/35633070
Autor:
Brian O. Smith, Amy J. Tibbo, William Fuller, George S. Baillie, Caglar Gök, Aisling McFall, Niall MacQuaide, Gonzalo S. Tejeda, Ruth MacLeod, Godfrey L. Smith, Connor M. Blair, Thomas Brand, Sara Dobi
Cyclic AMP is a ubiquitous second messenger used to transduce intracellular signals from a variety of Gs-coupled receptors. Compartmentalisation of protein intermediates within the cAMP signaling pathway underpins receptor-specific responses. The cAM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::662d72da79fdb83266d8ecdc28d28a77
https://doi.org/10.1101/2020.09.10.290825
https://doi.org/10.1101/2020.09.10.290825
Autor:
George S. Baillie, Amy J. Tibbo
Publikováno v:
Cells, Vol 9, Iss 1254, p 1254 (2020)
Cells
Cells
Phosphodiesterases (PDEs) are the only superfamily of enzymes that have the ability to break down cyclic nucleotides and, as such, they have a pivotal role in neurological disease and brain development. PDEs have a modular structure that allows targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740eb00a683d169496ab6dffa82d2b26
https://www.mdpi.com/2073-4409/9/5/1254
https://www.mdpi.com/2073-4409/9/5/1254
Publikováno v:
Biochemical Society Transactions
Phosphodiesterases (PDEs) have long been considered as targets for the treatment of Alzheimer's disease (AD) and a substantial body of evidence suggests that one sub-family from the super-family of PDEs, namely PDE4D, has particular significance in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a426dd5daf98c9b593fbb7e88e6d8e3
https://pubmed.ncbi.nlm.nih.gov/31642904
https://pubmed.ncbi.nlm.nih.gov/31642904
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1957
The many functions of β-arrestin proteins in the desensitization of G-protein-coupled receptors have been well characterized; however, the discovery that this scaffold protein could actually recruit phosphodiesterases (PDEs) to the site of cAMP synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b2c48e36846f713718c35bddac644d66
https://pubmed.ncbi.nlm.nih.gov/30919351
https://pubmed.ncbi.nlm.nih.gov/30919351
Publikováno v:
Beta-Arrestins ISBN: 9781493991570
The many functions of β-arrestin proteins in the desensitization of G-protein-coupled receptors have been well characterized; however, the discovery that this scaffold protein could actually recruit phosphodiesterases (PDEs) to the site of cAMP synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d39fc27b8b0c0f12fdd3d43a11e3e48
https://doi.org/10.1007/978-1-4939-9158-7_8
https://doi.org/10.1007/978-1-4939-9158-7_8