Výsledky vyhledávání - "Amy J. Pfizenmayer"

[Lys3]didemnins as potential affinity ligands

Autor: Matthew D. Vera, Dong Xiao, Amy J. Pfizenmayer, Xiaobin Ding, Madeleine M. Joullié

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 11:13-16

The synthesis and biological activity of N e -Z-[Lys 3 ]didemnin B are reported. This novel analogue retains antiproliferative, cytotoxic, and protein biosynthesis inhibition activities, but at reduced levels. This result suggests the use of [Lys 3 ]

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8f4f359131f8be6bd62279d8aabc70
https://doi.org/10.1016/s0960-894x(00)00585-0

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Synthesis and biological activities of [N-MeLeu5]- and [N-MePhe5]-didemnin B

Autor: Joshi M. Ramanjulu, Matthew D. Vera, Chen Wei-Chuan, Madeleine M. Joullié, Dong Xiao, Xiaobin Ding, Amy J. Pfizenmayer

Publikováno v: Tetrahedron. 55:313-334

Based on information from X-ray, NMR, and SAR data, the N , O -diMeTyr 5 unit of didemnin B was believed to be important for biological activity. To determine the importance of aromaticity and the role of the methoxy group in this unit, two analogs w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32671c81355db90debf9f240e9310b8f
https://doi.org/10.1016/s0040-4020(98)01042-4

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Synthesis and biological activity of [Tic5] didemnin B

Autor: Matthew D. Vera, Deepika Tandon, Amy J. Pfizenmayer, Wei-Chuan Chen, Peter L. Toogood, Madeleine M. Joullié, Xiaobin Ding, Dong Xiao

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 8:3653-3656

A didemnin B analog containing a Tic (1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) as a conformationally restrained replacement for tyrosine has been synthesized and shown to have comparable potency as a protein biosynthesis inhibitor. Synthetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af2a939ab6cc268e876977e05068bc4
https://doi.org/10.1016/s0960-894x(98)00662-3

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Stereoselective synthesis of a conformationally restricted β-hydroxy-λ-amino acid

Autor: Dong Xiao, Patrick J. Carroll, Madeleine M. Joullié, Amy J. Pfizenmayer, S. C. Mayer

Publikováno v: Tetrahedron: Asymmetry. 8:3043-3046

β-Hydroxy-λ-amino acids are a class of non-proteinogenic amino acids present in many important biologically active natural products. In conjunction with our research on didemnins, we designed and synthesized a sterically constrained β-hydroxy-λ-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53122c9ecc30bdef333db1fb43f301be
https://doi.org/10.1016/s0957-4166(97)00402-3

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Synthetic studies of a constrained ring didemnin analog

Autor: Scott C. Mayor, Madeleine M. Joullié, Amy J. Pfizenmayer, Wen Ren Li, Richard Cordova

Publikováno v: Tetrahedron: Asymmetry. 5:519-522

An asymmetric Diels-Alder reaction in the presence of 3.0 M lithium perchlorate-diethyl ether was used to generate the initial stereochemistry for a cyclohexane amino acid (3), a key intermediate in the preparation of a fused ring didemnin analog. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f7eccd14d9a75716d4441658bc31e54
https://doi.org/10.1016/0957-4166(94)80007-3

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