Expression and function of NPSR1/GPRA in the lung before and after induction of asthma-like disease

Autor: Leigh A. Jania, Julie G. Ledford, John N. Snouwaert, Anne M. Latour, Virginie Bernier, Beverly H. Koller, Alex G. Therien, Amy J. Pace, Irving C. Allen, Rino Stocco

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 291:L1005-L1017

A genetic contribution to asthma susceptibility is well recognized, and linkage studies have identified a large number of genes associated with asthma pathogenesis. Recently, a locus encoding a seven-transmembrane protein was shown to be associated w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61ec348c59ec66eeb420e2da40494c1
https://doi.org/10.1152/ajplung.00174.2006

Role of Na-K-2Cl cotransporter-1 in gastric secretion of nonacidic fluid and pepsinogen

Autor: Ursula Seidler, Nichole McDaniel, Regina Engelhardt, Amy J. Pace, Stefanie Spiegel, Christian Lytle, Beverly H. Koller

Publikováno v: American journal of physiology. Gastrointestinal and liver physiology, vol 289, iss 3
McDaniel, Nichole; Pace, Amy J; Spiegel, Stefanie; Engelhardt, Regina; Koller, Beverly H; Seidler, Ursula; et al.(2005). Role of Na-K-2Cl cotransporter-1 in gastric secretion of nonacidic fluid and pepsinogen. American Journal of Physiology-Gastrointestinal and Liver Physiology, 289(3), G550-G560. doi: 10.1152/ajpgi.00095.2005. UC Riverside: Retrieved from: http://www.escholarship.org/uc/item/1z03x9qk

Na-K-2Cl cotransporter-1 (NKCC) has been detected at exceptionally high levels in the gastric mucosa of several species, prompting speculation that it plays important roles in gastric secretion. To investigate this possibility, we 1) immunolocalized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::360797d198c97bc60d32624f04a885a5
https://doi.org/10.1152/ajpgi.00095.2005

Liquid and Ion Transport by Fetal Airway and Lung Epithelia of Mice Deficient in Sodium-Potassium-2-Chloride Transporter

Autor: Pierre M. Barker, Amy J. Pace, Beverly H. Koller, Daniel J. Gillie, Ray J. Coakley

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 25:14-20

Chloride (Cl(-)) movement across fetal lung epithelia is thought to be mediated by the sodium-potassium-2-Cl(-) cotransporter NKCC1. We studied the role of NKCC1 in Cl(-) and liquid secretion in late-gestation NKCC-null (-/-) and littermate control f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2f2c8ee1ca73b6a437bf5ec4975923
https://doi.org/10.1165/ajrcmb.25.1.4500

Intestinal ion transport in NKCC1-deficient mice

Autor: Amy J. Pace, Beverly H. Koller, Barbara R. Grubb, R. C. Boucher, Eddie Lee

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 279:G707-G718

The Na+-K+-2Cl− cotransporter (NKCC1) located on the basolateral membrane of intestinal epithelia has been postulated to be the major basolateral Cl− entry pathway. With targeted mutagenesis, mice deficient in the NKCC1 protein were generated. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e857f67e564d55a40d0c934b3eb15b4
https://doi.org/10.1152/ajpgi.2000.279.4.g707

Dimerization of the Calcium-sensing Receptor Occurs within the Extracellular Domain and Is Eliminated by Cys → Ser Mutations at Cys101 and Cys236

Autor: Amy J. Pace, Lucio Gama, Gerda E. Breitwieser

Publikováno v: Journal of Biological Chemistry. 274:11629-11634

Calcium-sensing receptors are present in membranes as dimers that can be reduced to monomers with sufhydryl reagents. All studies were carried out on the human calcium-sensing receptor tagged at the carboxyl terminus with green fluorescent protein (h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd22c9bd9a0ddea3d9cd794c771f93d
https://doi.org/10.1074/jbc.274.17.11629