Probing the distinct chemosensitivity of Plasmodium vivax liver stage parasites and demonstration of 8-aminoquinoline radical cure activity in vitro

Autor: Steven P. Maher, Amélie Vantaux, Victor Chaumeau, Adeline C. Y. Chua, Caitlin A. Cooper, Chiara Andolina, Julie Péneau, Mélanie Rouillier, Zaira Rizopoulos, Sivchheng Phal, Eakpor Piv, Chantrea Vong, Sreyvouch Phen, Chansophea Chhin, Baura Tat, Sivkeng Ouk, Bros Doeurk, Saorin Kim, Sangrawee Suriyakan, Praphan Kittiphanakun, Nana Akua Awuku, Amy J. Conway, Rays H. Y. Jiang, Bruce Russell, Pablo Bifani, Brice Campo, François Nosten, Benoît Witkowski, Dennis E. Kyle

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)

Abstract Improved control of Plasmodium vivax malaria can be achieved with the discovery of new antimalarials with radical cure efficacy, including prevention of relapse caused by hypnozoites residing in the liver of patients. We screened several com

Externí odkaz: https://doaj.org/article/82bd81cce09f483dac02985c053a9b50

Author Correction: A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum

Autor: Alison Roth, Steven P. Maher, Amy J. Conway, Ratawan Ubalee, Victor Chaumeau, Chiara Andolina, Stephen A. Kaba, Amélie Vantaux, Malina A. Bakowski, Richard Thomson-Luque, Swamy Rakesh Adapa, Naresh Singh, Samantha J. Barnes, Caitlin A. Cooper, Mélanie Rouillier, Case W. McNamara, Sebastian A. Mikolajczak, Noah Sather, Benoît Witkowski, Brice Campo, Stefan H. I. Kappe, David E. Lanar, François Nosten, Silas Davidson, Rays H. Y. Jiang, Dennis E. Kyle, John H. Adams

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)

The original version of this Article contained an error in the spelling of Richard Thomson-Luque, which was incorrectly given as Richard Thomson Luque. This error has now been corrected in both the PDF and HTML versions of the Article.

Externí odkaz: https://doaj.org/article/73adfbdede8e4de38681a2951dacd5ea

An adaptable soft-mold embossing process for fabricating optically-accessible, microfeature-based culture systems and application toward liver stage antimalarial compound testing

Autor: Raahil S. Patel, Brice Campo, Jetsumon Sattabongkot, Steven P. Maher, Chris Palmiotti, Chiara Andolina, Rays H. Y. Jiang, Alison Roth, Phillip Cualing, Dennis E. Kyle, Jessica Turgeon, Robert Carter, John H. Adams, Swamy R. Adapa, Wajeeh M. Saadi, Virginia Van Grod, François Nosten, Amy J. Conway, Myles E. Johnson, Samantha J. Barnes, Naresh Singh, H-C Steve Sun, Victor Chaumeau, James C. Hsiao

Publikováno v: Lab on a Chip. 20:1124-1139

Advanced cell culture methods for modeling organ-level structure have been demonstrated to replicate in vivo conditions more accurately than traditional in vitro cell culture. Given that the liver is particularly important to human health, several ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b5926a5d714e8c45a09f91b21b579d0
https://doi.org/10.1039/c9lc00921c

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

Autor: Case W. McNamara, Dyann F. Wirth, Francisco-Javier Gamo, Dionicio Siegel, Yevgeniya Antonova-Koch, Dennis E. Kyle, Korina Eribez, Cullin McLean Taggard, Maureen Ibanez, François Nosten, Yang Zhong, Sabine Ottilie, Edward Owen, Victor Chaumeau, Jeremy N. Burrows, Kaisheng Chen, Elizabeth A. Winzeler, Mélanie Rouillier, Madeline R. Luth, Christie Lincoln, Stephan Meister, Juan Carlos Jado, Tomoyo Sakata-Kato, David A. Fidock, Yingyao Zhou, Kerstin Gagaring, Manuel Llinás, Jaeson Calla, Biniam Ambachew, Matthew Abraham, Amanda K. Lukens, Amy J. Conway, Fernando Neria Serrano, Manu Vanaerschot, Andrea L. Cheung, Brice Campo, Steven P. Maher, David Plouffe

Publikováno v: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Science (New York, N.Y.), vol 362, iss 6419
Science (New York, N.y.)

To discover leads for next-generation chemoprotective antimalarial drugs,we tested more than 500,000 compounds for their ability to inhibit liver-stage development of luciferase-expressing Plasmodium spp. parasites (681 compounds showed a half-maxima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276ca79aa5124b1a30513b1776aa4ace
https://doi.org/10.1126/science.aat9446

Microfluidic Biopsy Trapping Device for the Real-Time Monitoring of Tumor Microenvironment

Autor: Amy J. Conway, David Landis, Jenny Kreahling, Francy L. Sinatra, Angela Holton, Soner Altiok

Publikováno v: PLoS ONE
PLoS ONE, Vol 12, Iss 1, p e0169797 (2017)

The tumor microenvironment is composed of cellular and stromal components such as tumor cells, mesenchymal cells, immune cells, cancer associated fibroblasts and the supporting extracellular matrix. The tumor microenvironment provides crucial support

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2acc42cdb3bd8df7a6f830e0496b9729
https://pubmed.ncbi.nlm.nih.gov/28085924