Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Amy J. Campbell"'
Publikováno v:
Journal of Child and Family Studies. 32:1280-1293
Autor:
Therese Ku, Sonia G. Thangavelu, Farhat Khan, Benjamin Hoyt, Christine A. Herdman, Richard K. Gordon, Amy J. Campbell
Publikováno v:
Life Sciences. 89:911-917
Aims Due to pralidoxime chloride's (2-PAM) positive charge, it's penetration through the blood brain barrier (BBB) and reactivation of organophosphate (OP) inhibited central nervous system (CNS) acetylcholinesterase (AChE) is poor. The results of CNS
Autor:
Amy J. Campbell, Victoria E. Albrow, James C. Powers, Elizabeth L. Ponder, Junpeng Xiao, Miklós Békés, Edgar Deu, Urša Pečar Fonović, Marcin Drag, Jowita Mikolajczyk, Brittany A. Leader, Matthew Bogyo, Aimee Shen, Guy S. Salvesen
Publikováno v:
Chemistry & Biology. 18:711-721
SummarySmall ubiquitin-related modifier (SUMO) is implicated in the regulation of numerous biological processes including transcription, protein localization, and cell cycle control. Protein modification by SUMO is found in Plasmodium falciparum; how
Autor:
Amy J. Campbell, Marie A. Medynets, James C. DeMar, Richard K. Gordon, Haim Leader, Therese Ku, Madhusoodana P. Nambiar, Ruthie H Ratcliffe, Christine A. Herdman, Sonia G. Thangavelu, Edward D. Clarkson, Elizabeth Marek, Roberta R. Owens, Sarah Evans, Farhat Khan, Susan Schulz
Publikováno v:
Chemico-Biological Interactions. 187:191-198
Novel therapeutics to overcome the toxic effects of organophosphorus (OP) chemical agents are needed due to the documented use of OPs in warfare (e.g. 1980–1988 Iran/Iraq war) and terrorism (e.g. 1995 Tokyo subway attacks). Standard OP exposure the
Autor:
Jonathan A. Gordon, Richard K. Gordon, Apurba K. Bhattacharjee, Elizabeth Marek, Amy J. Campbell
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:3999-4012
Muscarinic acetylcholine receptors (mAChRs) consisting of five known subtypes, are widely distributed in both central and peripheral nervous systems for regulation of a variety of critical functions. The present theoretical study describes correlatio
Exploring the S4 and S1 Prime Subsite Specificities in Caspase-3 with Aza-Peptide Epoxide Inhibitors
Autor:
Stjepan Jelakovic, Juliana L. Asgian, Markus G. Grütter, Rajkumar Ganesan, Zhao Zhao Li, Amy J. Campbell, James C. Powers
Publikováno v:
Biochemistry. 45:9059-9067
Caspase-3 is a prototypic executioner caspase that plays a central role in apoptosis. Aza-peptide epoxides are a novel class of irreversible inhibitors that are highly specific for clan CD cysteine proteases. The five crystal structures of caspase-3-
Publikováno v:
Chemico-biological interactions. 187(1-3)
The US Army utilizes pralidoxime (2-PAM) for the reactivation of OP-inhibited AChE. While 2-PAM effectively reactivates acetylcholinesterase (AChE) in the body, it does not cross the blood–brain barrier (BBB) at therapeutically relevant levels. To
Publikováno v:
The FASEB Journal. 23
Publikováno v:
The FASEB Journal. 23
Autor:
Juliana L Asgian, Markus G. Grütter, Amy J. Campbell, Özlem Doğan Ekici, Jowita Mikolajczyk, Karen Ellis James, James C Powers, Zhao Zhao Li, Guy S. Salvesen, Stjepan Jelakovic, Rajkumar Ganesan
Publikováno v:
Journal of medicinal chemistry. 49(19)
Aza-peptide Michael acceptors are a novel class of inhibitors that are potent and specific for caspases-2, -3, -6, -7, -8, -9, and -10. The second-order rate constants are in the order of 10(6) M(-1) s(-1). The aza-peptide Michael acceptor inhibitor