Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Amy J. Barr"'
Autor:
Jason R.B. Dyck, John M. Seubert, Wentong Long, Peter E. Light, Taylor Palechuk, Chloe Schneider, Amy J. Barr, Nikole J. Byrne, Jyoti Singh, Khaled Barakat, Ahmed M. Darwesh, Koenraad Philippaert, Subha Kalyaanamoorthy, Mohammad Fatehi, Jordan Wong, Shubham Soni, Zaid H. Maayah
Publikováno v:
Circulation
Supplemental Digital Content is available in the text.
Background: SGLT2 (sodium/glucose cotransporter 2) inhibitors exert robust cardioprotective effects against heart failure in patients with diabetes, and there is intense interest to identify
Background: SGLT2 (sodium/glucose cotransporter 2) inhibitors exert robust cardioprotective effects against heart failure in patients with diabetes, and there is intense interest to identify
Autor:
Mohammad Fatehi, Peter E. Light, Wentong Long, Shubham Soni, Brett Boonen, Koenraad Philippaert, Rees G. Kelly, Katarina Ondrusova, M. Joanne Lemieux, Dominic P. Golec, Rashmi Panigrahi, Amy J. Barr, Yi Yu, Matt Hubert, Troy A. Baldwin, Scott A. Campbell
Publikováno v:
The Journal of Physiology. 598:4321-4338
KEY POINTS: 25-Hydroxyvitamin D (25OHD) is a partial agonist of TRPV1 whereby 25OHD can weakly activate TRPV1 yet antagonize the stimulatory effects of the full TRPV1 agonists capsaicin and oleoyl dopamine. 25OHD binds to TRPV1 within the same vanill
Autor:
Carlos Flores-Mir, Pranidhi Baddam, Joanna E. MacLean, Rupasri Mandal, Farah Eaton, Daniel Graf, Vivian Biancardi, Amy J. Barr, Daniela Marta Roth, David S. Wishart, Silvia Pagliardini, Claudine Thereza-Bussolaro
Publikováno v:
Disease Models & Mechanisms
article-version (VoR) Version of Record
Disease Models & Mechanisms, Vol 14, Iss 2 (2021)
article-version (VoR) Version of Record
Disease Models & Mechanisms, Vol 14, Iss 2 (2021)
Pediatric obstructive sleep apnea (OSA), a relatively common sleep-related breathing disorder affecting ∼1-5% of children, is often caused by anatomical obstruction and/or collapse of the nasal and/or pharyngeal airways. The resulting sleep disrupt
Autor:
Jason R.B. Dyck, Scott A. Campbell, Peter E. Light, Beth E. Hunter, Manoj Gandhi, Nermeen Youssef, Amy J. Barr, Alexander S. Clanachan, Vernon W. Dolinsky
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 313:H469-H478
Cardiac ATP-sensitive K+ (KATP) channels couple changes in cellular metabolism to membrane excitability and are activated during metabolic stress, although under basal aerobic conditions, KATP channels are thought to be predominately closed. Despite
Autor:
Peter E. Light, Mohammad Fatehi, Scott A. Campbell, Rashmi Panigrahi, Troy A. Baldwin, Rees G. Kelly, Joanne Lemieux, Shubham Soni, Katarina Ondrusova, Koenraad Philippaert, Amy J. Barr, Yi Yu, Morganne Held, Wentong Long
Publikováno v:
Diabetes. 68
The autoimmune disease of type 1 diabetes (T1D) results in the immune destruction of β-cells. Recent studies suggest supplementation of vitamin D along can significantly improve patients’ β-cell function and glycemic control possibly by dampening
Autor:
Mohammad Fatehi, Peter E. Light, Kunimasa Suzuki, Amy J. Barr, Wentong Long, Zofia Prus-Czarnecka, Scott A. Campbell, Katarina Ondrusova
Publikováno v:
Canadian Journal of Diabetes. 41:S34-S35
Autor:
Yi Yutroy Baldwin, Peter E. Light, Rees G. Kelly, Wentong Long, Mohammad Fatehi, Amy J. Barr, Morganne Held
Publikováno v:
Canadian Journal of Diabetes. 41:S32-S33
Autor:
Matthew Hubert, Wentong Long, Peter E. Light, Scott A. Campbell, Katarina Ondrusova, Mohammed Fatehi, Amy J. Barr
Publikováno v:
Canadian Journal of Diabetes. 41:S12
Autor:
Suzanne Kovacic, Kenneth Walsh, Jason R.B. Dyck, Amy J. Barr, Carrie-Lynn M. Soltys, Ichiro Shiojima
Publikováno v:
Journal of Biological Chemistry. 278:39422-39427
In the heart, insulin stimulates a variety of kinase cascades and controls glucose utilization. Because insulin is able to activate Akt and inactivate AMP-activated protein kinase (AMPK) in the heart, we hypothesized that Akt can regulate the activit
Autor:
Jason R.B. Dyck, Amy J. Barr, Gary D. Lopaschuk, Rick L. Barr, Paul F. Kantor, Panakkezhum D. Thomas, Marc Prentki, Luc G. Berthiaume, Dyal Singh, Teresa A. Hopkins, Nicolas Voilley
Publikováno v:
Biochemical Journal. 350:599-608
In the liver, malonyl-CoA is central to many cellular processes, including both fatty acid biosynthesis and oxidation. Malonyl-CoA decarboxylase (MCD) is involved in the control of cellular malonyl-CoA levels, and functions to decarboxylate malonyl-C