Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Amy J Curwin"'
Autor:
Amy J Curwin, Nathalie Brouwers, Manuel Alonso Y Adell, David Teis, Gabriele Turacchio, Seetharaman Parashuraman, Paolo Ronchi, Vivek Malhotra
Publikováno v:
eLife, Vol 5 (2016)
The unconventional secretory pathway exports proteins that bypass the endoplasmic reticulum. In Saccharomyces cerevisiae, conditions that trigger Acb1 secretion via this pathway generate a Grh1 containing compartment composed of vesicles and tubules
Externí odkaz:
https://doaj.org/article/951a2b90e2ef44959bf0bf1e60122e9e
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55388 (2013)
The Sec14 protein domain is a conserved tertiary structure that binds hydrophobic ligands. The Sec14 protein from Saccharomyces cerevisiae is essential with studies of S. cerevisiae Sec14 cellular function facilitated by a sole temperature sensitive
Externí odkaz:
https://doaj.org/article/a3cc255ebcd948818cf91b34c3ed5e17
Autor:
Gerard, Cantero-Recasens, Carla, Burballa, Yuki, Ohkawa, Tomohiko, Fukuda, Yoichiro, Harada, Amy J, Curwin, Nathalie, Brouwers, Gian A, Thun, Jianguo, Gu, Ivo, Gut, Naoyuki, Taniguchi, Vivek, Malhotra
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(43)
Mucins are the main macrocomponents of the mucus layer that protects the digestive tract from pathogens. Fucosylation of mucins increases mucus viscoelasticity and its resistance to shear stress. These properties are altered in patients with ulcerati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b477ea6fd963c2d7a9c3dece8a234ee8
https://pubmed.ncbi.nlm.nih.gov/36252012
https://pubmed.ncbi.nlm.nih.gov/36252012
Autor:
Amy J. Curwin, Jianguo Gu, Tomohiko Fukuda, Gerard Cantero, Yoichiro Harada, Gian Andri Thun, Ivo Gut, Yuki Ohkawa, Nathalie Brouwers, Carla Burballa, Vivek Malhotra
Fucosylation of mucins, the main macrocomponents of the mucus layer that protects the digestive tract from pathogens, increases their viscoelasticity and shear stress resistance. These properties are altered in patients with ulcerative colitis (UC),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0423074fcb4c95cba75167a49ddbed12
https://doi.org/10.1101/2021.11.30.469270
https://doi.org/10.1101/2021.11.30.469270
CUPS, a compartment for unconventional secretion of signal sequence lacking proteins, is built during starvation. CUPS, lacking the Golgi specific glycosyltransferases, form by COPI independent extraction of membranes from the early Golgi cisterna, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e626c776c0e981db955a17938226b44
https://doi.org/10.1101/2021.10.22.465504
https://doi.org/10.1101/2021.10.22.465504
Publikováno v:
The Journal of Cell Biology
Cruz-Garcia et al. show that production of ROS upon nutrient starvation in yeast promotes secretion of antioxidants and the signaling protein Acb1. These secreted proteins are necessary to maintain cell viability till cells return to favorable growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030835d3f9cbf7789ec11770048b36af
https://doi.org/10.1083/jcb.201905028
https://doi.org/10.1083/jcb.201905028
Autor:
David Cruz-Garcia, Vivek Malhotra, Amy J. Curwin, Gabriel Mora, Juan M. Duran, Nathalie Brouwers
Publikováno v:
The Journal of Cell Biology
Starvation-induced unconventional secretion of Acb1 requires ESCRT-I, -II, and -III and Grh1. Cruz-Garcia et al. report that SOD1 and its mutant form linked to amyotrophic lateral sclerosis are also secreted upon nutrient starvation in a Grh1- and ES
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc51d7f08cac8b6373922010cfcbd8a
http://europepmc.org/articles/PMC5584182
http://europepmc.org/articles/PMC5584182
Nutrient deprivation triggers the release of signal-sequence-lacking Acb1 and the antioxidant superoxide dismutase 1 (SOD1). We now report that secreted SOD1 is functionally active and accompanied by export of other antioxidant enzymes such as thiore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d94a5ec44c179981add1a54cc6cd98
https://doi.org/10.1101/628321
https://doi.org/10.1101/628321
Publikováno v:
Seminars in celldevelopmental biology. 83
It is usually assumed that eukaryotic cells secrete only proteins that contain a signal sequence for Sec61 mediated translocation into the lumen of endoplasmic reticulum (ER). Surprisingly however, many proteins, such as superoxide dismutase (SOD)1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e576a71f498f681559cdeab86b832659
https://pubmed.ncbi.nlm.nih.gov/29486236
https://pubmed.ncbi.nlm.nih.gov/29486236
Autor:
Manuel Alonso Y Adell, David Teis, Nathalie Brouwers, Seetharaman Parashuraman, Vivek Malhotra, Gabriele Turacchio, Paolo Ronchi, Amy J. Curwin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8cf0e7e880784f023900d176adc7988
https://doi.org/10.7554/elife.16299.018
https://doi.org/10.7554/elife.16299.018