Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Amy Hin Yan Tong"'
Autor:
Sylvia Varland, Rui Duarte Silva, Ine Kjosås, Alexandra Faustino, Annelies Bogaert, Maximilian Billmann, Hadi Boukhatmi, Barbara Kellen, Michael Costanzo, Adrian Drazic, Camilla Osberg, Katherine Chan, Xiang Zhang, Amy Hin Yan Tong, Simonetta Andreazza, Juliette J. Lee, Lyudmila Nedyalkova, Matej Ušaj, Alexander J. Whitworth, Brenda J. Andrews, Jason Moffat, Chad L. Myers, Kris Gevaert, Charles Boone, Rui Gonçalo Martinho, Thomas Arnesen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-27 (2023)
Abstract Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global scale has remained obscure. Using genome-wide CRISPR knockout screens in human cells, we reveal a strong genetic dependency between a major N-termina
Externí odkaz:
https://doaj.org/article/d00c6a73922e4ae69223e5ddad630fd5
Autor:
Katherine Chan, Adrian Granda Farias, Hunsang Lee, Furkan Guvenc, Patricia Mero, Kevin R. Brown, Henry Ward, Maximilian Billmann, Kamaldeep Aulakh, Audrey Astori, Shahan Haider, Edyta Marcon, Ulrich Braunschweig, Shuye Pu, Andrea Habsid, Amy Hin Yan Tong, Natasha Christie-Holmes, Patrick Budylowski, Ayoob Ghalami, Samira Mubareka, Finlay Maguire, Arinjay Banerjee, Karen L. Mossman, Jack Greenblatt, Scott D. Gray-Owen, Brian Raught, Benjamin J. Blencowe, Mikko Taipale, Chad Myers, Jason Moffat
Publikováno v:
Heliyon, Vol 9, Iss 1, Pp e12744- (2023)
SARS-CoV-2 depends on host cell components for infection and replication. Identification of virus-host dependencies offers an effective way to elucidate mechanisms involved in viral infection and replication. If druggable, host factor dependencies ma
Externí odkaz:
https://doaj.org/article/1fc0974096af4f23af93d99b3d0085a0
Autor:
Sergey V. Venev, Athma A. Pai, Matej Usaj, Katherine S. K. Chan, Barbara Mair, Amy Hin Yan Tong, Jason Moffat, Eraj Khokhar, Job Dekker, Anne-Laure Valton
Publikováno v:
Nat Struct Mol Biol
SUMMARYCohesin-mediated loop extrusion folds interphase chromosomes at the ten to hundreds kilobases scale. This process produces structural features such as loops and topologically associating domains. We identify three types of cis-elements that de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707f36c9ae1b2c5f86f9ff94cbb3fd01
https://doi.org/10.1038/s41594-022-00890-9
https://doi.org/10.1038/s41594-022-00890-9
Autor:
Na Zhang, Yun-Juan Bao, Amy Hin-Yan Tong, Scott Zuyderduyn, Gary D. Bader, J. S. Malik Peiris, Si Lok, Suki Man-Yan Lee
Publikováno v:
BMC Medical Genomics, Vol 11, Iss 1, Pp 1-14 (2018)
Abstract Background Avian influenza A H5N1 virus can cause lethal disease in humans. The virus can trigger severe pneumonia and lead to acute respiratory distress syndrome. Data from clinical, in vitro and in vivo suggest that virus-induced cytokine
Externí odkaz:
https://doaj.org/article/8847b8b898ae4b77a3f51cb09280efc6
Autor:
Traver Hart, Amy Hin Yan Tong, Katie Chan, Jolanda Van Leeuwen, Ashwin Seetharaman, Michael Aregger, Megha Chandrashekhar, Nicole Hustedt, Sahil Seth, Avery Noonan, Andrea Habsid, Olga Sizova, Lyudmila Nedyalkova, Ryan Climie, Leanne Tworzyanski, Keith Lawson, Maria Augusta Sartori, Sabriyeh Alibeh, David Tieu, Sanna Masud, Patricia Mero, Alexander Weiss, Kevin R. Brown, Matej Usaj, Maximilian Billmann, Mahfuzur Rahman, Michael Constanzo, Chad L. Myers, Brenda J. Andrews, Charles Boone, Daniel Durocher, Jason Moffat
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 8, Pp 2719-2727 (2017)
The adaptation of CRISPR/SpCas9 technology to mammalian cell lines is transforming the study of human functional genomics. Pooled libraries of CRISPR guide RNAs (gRNAs) targeting human protein-coding genes and encoded in viral vectors have been used
Externí odkaz:
https://doaj.org/article/d4b448c162324c49bda2645179b12775
Autor:
Si Lok, Tara A. Paton, Zhuozhi Wang, Gaganjot Kaur, Susan Walker, Ryan K. C. Yuen, Wilson W. L. Sung, Joseph Whitney, Janet A. Buchanan, Brett Trost, Naina Singh, Beverly Apresto, Nan Chen, Matthew Coole, Travis J. Dawson, Karen Ho, Zhizhou Hu, Sanjeev Pullenayegum, Kozue Samler, Arun Shipstone, Fiona Tsoi, Ting Wang, Sergio L. Pereira, Pirooz Rostami, Carol Ann Ryan, Amy Hin Yan Tong, Karen Ng, Yogi Sundaravadanam, Jared T. Simpson, Burton K. Lim, Mark D. Engstrom, Christopher J. Dutton, Kevin C. R. Kerr, Maria Franke, William Rapley, Richard F. Wintle, Stephen W. Scherer
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 2, Pp 755-773 (2017)
The Canadian beaver (Castor canadensis) is the largest indigenous rodent in North America. We report a draft annotated assembly of the beaver genome, the first for a large rodent and the first mammalian genome assembled directly from uncorrected and
Externí odkaz:
https://doaj.org/article/2b66b58c15d04d46bfd3af88bdababdc
Autor:
Barbara Mair, Jelena Tomic, Sanna N. Masud, Peter Tonge, Alexander Weiss, Matej Usaj, Amy Hin Yan Tong, Jamie J. Kwan, Kevin R. Brown, Emily Titus, Michael Atkins, Katherine S.K. Chan, Lise Munsie, Andrea Habsid, Hong Han, Marion Kennedy, Brenda Cohen, Gordon Keller, Jason Moffat
Publikováno v:
Cell Reports, Vol 27, Iss 2, Pp 599-615.e12 (2019)
Summary: Human pluripotent stem cells (hPSCs) provide an invaluable tool for modeling diseases and hold promise for regenerative medicine. For understanding pluripotency and lineage differentiation mechanisms, a critical first step involves systemati
Externí odkaz:
https://doaj.org/article/b48e7be0191349729bde89c8056e0021
Autor:
Jessica A. Stewart, Javier M. Di Noia, Amy Hin Yan Tong, Diana Nakib, Maribel Berru, Alberto Martin, Katherine Chan, Noé Seija Desivo, Gholam Ali Kardar, James R. Carlyle, Daniel Durocher, Rukshana Mohamad-Ramshan, Yuqing Feng, Jason Moffat, Madusha L. W. Perera, Rossanna C. Pezo, Alejandro Álvarez-Quilón, Philip Barbulescu, Ashok S. Bhagwat, Gavin Li, Conglei Li
Publikováno v:
Nature
Activation-induced cytidine deaminase (AID) catalyses the deamination of deoxycytidines to deoxyuracils within immunoglobulin genes to induce somatic hypermutation and class-switch recombination1,2. AID-generated deoxyuracils are recognized and proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9900ef9c698a316ab01d156a02d6c7
https://doi.org/10.1038/s41586-021-04144-4
https://doi.org/10.1038/s41586-021-04144-4
Autor:
Sylvia Varland, Rui Duarte Silva, Ine Kjosås, Alexandra Faustino, Annelies Bogaert, Maximilian Billmann, Hadi Boukhatmi, Barbara Kellen, Michael Costanzo, Adrian Drazic, Camilla Osberg, Katherine Chan, Xiang Zhang, Amy Hin Yan Tong, Simonetta Andreazza, Juliette J. Lee, Lyudmila Nedyalkova, Matej Ušaj, Alexander J. Whitworth, Brenda J. Andrews, Jason Moffat, Chad L. Myers, Kris Gevaert, Charles Boone, Rui Gonçalo Martinho, Thomas Arnesen
SUMMARYMost eukaryotic proteins are N-terminally acetylated, but the functional impact on a global scale has remained obscure. Using genome-wide CRISPR knockout screens in human cells, we reveal a strong genetic dependency between a major N-terminal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::472d7ebf86dfc87e0dd7981753ee3159
https://doi.org/10.1101/2022.09.01.505523
https://doi.org/10.1101/2022.09.01.505523
Autor:
Shubha Vij, Heiner Kuhl, Inna S Kuznetsova, Aleksey Komissarov, Andrey A Yurchenko, Peter Van Heusden, Siddharth Singh, Natascha M Thevasagayam, Sai Rama Sridatta Prakki, Kathiresan Purushothaman, Jolly M Saju, Junhui Jiang, Stanley Kimbung Mbandi, Mario Jonas, Amy Hin Yan Tong, Sarah Mwangi, Doreen Lau, Si Yan Ngoh, Woei Chang Liew, Xueyan Shen, Lawrence S Hon, James P Drake, Matthew Boitano, Richard Hall, Chen-Shan Chin, Ramkumar Lachumanan, Jonas Korlach, Vladimir Trifonov, Marsel Kabilov, Alexey Tupikin, Darrell Green, Simon Moxon, Tyler Garvin, Fritz J Sedlazeck, Gregory W Vurture, Gopikrishna Gopalapillai, Vinaya Kumar Katneni, Tansyn H Noble, Vinod Scaria, Sridhar Sivasubbu, Dean R Jerry, Stephen J O'Brien, Michael C Schatz, Tamás Dalmay, Stephen W Turner, Si Lok, Alan Christoffels, László Orbán
Publikováno v:
PLoS Genetics, Vol 12, Iss 12, p e1006500 (2016)
[This corrects the article DOI: 10.1371/journal.pgen.1005954.].
Externí odkaz:
https://doaj.org/article/0ce6e7bf9da7485aa89031d98d6ddbd2