Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Amy Heptinstall"'
Autor:
Duncan C. Miller, Tristan Reuillon, Lauren Molyneux, Timothy Blackburn, Simon J. Cook, Noel Edwards, Jane A. Endicott, Bernard T. Golding, Roger J. Griffin, Ian Hardcastle, Suzannah J. Harnor, Amy Heptinstall, Pamela Lochhead, Mathew P. Martin, Nick C. Martin, Stephanie Myers, David R. Newell, Richard A. Noble, Nicole Phillips, Laurent Rigoreau, Huw Thomas, Julie A. Tucker, Lan-Zhen Wang, Michael J. Waring, Ai-Ching Wong, Stephen R. Wedge, Martin E. M. Noble, Celine Cano
Publikováno v:
Journal of Medicinal Chemistry. 65:6513-6540
The nonclassical extracellular signal-related kinase 5 (ERK5) mitogen-activated protein kinase pathway has been implicated in increased cellular proliferation, migration, survival, and angiogenesis; hence, ERK5 inhibition may be an attractive approac
Autor:
Duncan C, Miller, Mathew P, Martin, Santosh, Adhikari, Alfie, Brennan, Jane A, Endicott, Bernard T, Golding, Ian R, Hardcastle, Amy, Heptinstall, Stephen, Hobson, Claire, Jennings, Lauren, Molyneux, Yvonne, Ng, Stephen R, Wedge, Martin E M, Noble, Celine, Cano
Publikováno v:
Organic & Biomolecular Chemistry
Structure-guided expansion of a fragment hit for the ATAD2 bromodomain enabled improvement in ATAD2 inhibition and selectivity over BRD4.
ATAD2 is an ATPase that is overexpressed in a variety of cancers and associated with a poor patient prognos
ATAD2 is an ATPase that is overexpressed in a variety of cancers and associated with a poor patient prognos