Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Amy Henrickson"'
Autor:
Ishtiyaq Ahmed, Jeanette Hahn, Amy Henrickson, Faisal Tarique Khaja, Borries Demeler, David Dubnau, Matthew B. Neiditch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
ComEA is a DNA-binding protein required for DNA uptake during bacterial transformation. Here, Ahmed et al. determine X-ray crystal structures of ComEA from Gram-positive bacteria, identifying a domain that is absent in Gram-negative bacteria and driv
Externí odkaz:
https://doaj.org/article/f26f79080592443b98b7b3b4ad40850c
Autor:
Christopher R. Horne, Hariprasad Venugopal, Santosh Panjikar, David M. Wood, Amy Henrickson, Emre Brookes, Rachel A. North, James M. Murphy, Rosmarie Friemann, Michael D. W. Griffin, Georg Ramm, Borries Demeler, Renwick C. J. Dobson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The GntR superfamily is one of the largest families of transcription factors in prokaryotes. Here the authors combine biophysical analysis and structural biology to dissect the mechanism by which NanR — a GntR-family regulator — binds to its prom
Externí odkaz:
https://doaj.org/article/fbbaf67cd57e43b9861716dfe16d3c75
Autor:
Suman Nandy, Vijay M. Maranholkar, Mary Crum, Katherine Wasden, Ujwal Patil, Atul Goyal, Binh Vu, Katerina Kourentzi, William Mo, Amy Henrickson, Borries Demeler, Mehmet Sen, Richard C. Willson
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1281 (2023)
Staphylococcus aureus protein A (SpA) is an IgG Fc-binding virulence factor that is widely used in antibody purification and as a scaffold to develop affinity molecules. A cyclized SpA Z domain could offer exopeptidase resistance, reduced chromatogra
Externí odkaz:
https://doaj.org/article/10af5e21cb25436d8ede4415fe7ac977
Autor:
Barbara S. Soares, Surza Lucia G. Rocha, Viviane A. Bastos, Diogo B. Lima, Paulo C. Carvalho, Fabio C. Gozzo, Borries Demeler, Tayler L. Williams, Janelle Arnold, Amy Henrickson, Thomas J. D. Jørgensen, Tatiana A. C. B. Souza, Jonas Perales, Richard H. Valente, Bruno Lomonte, Francisco Gomes-Neto, Ana Gisele C. Neves-Ferreira
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2022)
DM64 is a toxin-neutralizing serum glycoprotein isolated from Didelphis aurita, an ophiophagous marsupial naturally resistant to snake envenomation. This 64 kDa antitoxin targets myotoxic phospholipases A2, which account for most local tissue damage
Externí odkaz:
https://doaj.org/article/d2f51dc524774961858c41c23f7b897f
Autor:
Juliet O. Obi, Mulu Y. Lubula, Gabriel Cornilescu, Amy Henrickson, Kara McGuire, Chiara M. Evans, Margaret Phillips, Samuel P. Boyson, Borries Demeler, John L. Markley, Karen C. Glass
Publikováno v:
Current Research in Structural Biology, Vol 2, Iss , Pp 104-115 (2020)
Bromodomain-containing proteins are often part of chromatin-modifying complexes, and their activity can lead to altered expression of genes that drive cancer, inflammation and neurological disorders in humans. Bromodomain-PHD finger protein 1 (BRPF1)
Externí odkaz:
https://doaj.org/article/373be060f02e4b3cb3c3da481b1aace9
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 6, p e1007942 (2020)
Recent advances in instrumentation have moved analytical ultracentrifugation (AUC) closer to a possible validation in a Good Manufacturing Practices (GMP) environment. In order for AUC to be validated for a GMP environment, stringent requirements nee
Externí odkaz:
https://doaj.org/article/cf83a3dd75d84f9491b269182f2a1ccf
Autor:
Corey R. Nelson, Tyler Mrozowich, Sean M. Park, Simmone D’souza, Amy Henrickson, Justin R. J. Vigar, Hans-Joachim Wieden, Raymond J. Owens, Borries Demeler, Trushar R. Patel
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 54 (2020)
Rift Valley fever virus (RVFV) is a mosquito-transmitted virus from the Bunyaviridae family that causes high rates of mortality and morbidity in humans and ruminant animals. Previous studies indicated that DEAD-box helicase 17 (DDX17) restricts RVFV
Externí odkaz:
https://doaj.org/article/08c72b2e3fb94fe29b35a169d943850a
Publikováno v:
Viruses, Vol 12, Iss 2, p 190 (2020)
Viral infections are responsible for numerous deaths worldwide. Flaviviruses, which contain RNA as their genetic material, are one of the most pathogenic families of viruses. There is an increasing amount of evidence suggesting that their 5’ and 3
Externí odkaz:
https://doaj.org/article/89915552fe4e49afa6084fb60f0ec228
Autor:
Tyler Mrozowich, Sean M Park, Maria Waldl, Amy Henrickson, Scott Tersteeg, Corey R Nelson, Anneke De Klerk, Borries Demeler, Ivo L Hofacker, Michael T Wolfinger, Trushar R Patel
Publikováno v:
Nucleic Acids Research. 51:4588-4601
Numerous viruses utilize essential long-range RNA–RNA genome interactions, specifically flaviviruses. Using Japanese encephalitis virus (JEV) as a model system, we computationally predicted and then biophysically validated and characterized its lon
Publikováno v:
Biochemistry and Cell Biology. 100:425-436
Inorganic pyrophosphatase (iPPase) is an enzyme that cleaves pyrophosphate into two phosphate molecules. This enzyme is an essential component of in vitro transcription (IVT) reactions for RNA preparation as it prevents pyrophosphate from precipitati