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Autor:
Johannes Schweizer, Yu Tian Wang, Carolyn Cobey, Michael P. Belmares, Michael W. Salter, Thuymy Phan, Peter S. Lu, Hong-Shuo Sun, Michael Tymianski, Amy Hayashi, David Garman, Hong Cui, Joshua D. Rabinowitz, R. Andrew R. Tasker
Publikováno v:
The Journal of Neuroscience. 27:9901-9915
In neuronal synapses, PDZ domains [postsynaptic density-95 (PSD-95)/Discs large/zona occludens-1] of PSD-95 proteins interact with C termini of NMDA receptor [NMDAR (NR)] subunits, linking them to downstream neurotoxic signaling molecules. Perturbing