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Targeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports

Human CLDN18.2 is highly expressed in a significant proportion of gastric and pancreatic adenocarcinomas, while normal tissue expression is limited to the epithelium of the stomach. The restricted expression makes it a potential drug target for the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1cb2d8e3557700b663eb82166441785
https://doi.org/10.1038/s41598-019-44874-0

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Identification and Evaluation of Novel MicroRNA Biomarkers in Plasma and Feces Associated with Drug-induced Intestinal Toxicity

Autor: Wesley Scott, Kyle Hayes, Amy H. Yang, Allison Vitsky, Dalia Kalabat, Annette John-Baptiste, Wenhu Huang, Erick Kindt

Publikováno v: Toxicologic Pathology. 45:302-320

Gastrointestinal toxicity is dose limiting with many therapeutic and anticancer agents. Real-time, noninvasive detection of markers of toxicity in biofluids is advantageous. Ongoing research has revealed microRNAs as potential diagnostic and predicti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2129e725b9adb9820dfa29644261988
https://doi.org/10.1177/0192623316644992

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Effective Targeting of Hedgehog Signaling in a Medulloblastoma Model with PF-5274857, a Potent and Selective Smoothened Antagonist That Penetrates the Blood–Brain Barrier

Autor: Shaoxian Sun, Darian Bartkowski, Greg Stevens, Bernadette Pascual, Rohner Allison Karlyn, Justine L. Lam, Sajiv Krishnan Nair, Simon Paul Planken, Meirong Xu, Amy H. Yang, Mary E. Spilker, Qing John Li, Peter A. Wells

Publikováno v: Molecular Cancer Therapeutics. 11:57-65

Inhibition of the Smoothened (Smo) represents a promising therapeutic strategy for treating malignant tumors that are dependent on the Hedgehog (Hh) signaling pathway. PF-5274857 is a novel Smo antagonist that specifically binds to Smo with a Ki of 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41efde188d7a01b6c3d222439dbd9c2e
https://doi.org/10.1158/1535-7163.mct-11-0691

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Clinicopathological and Tissue Indicators of Para-Aminophenol Nephrotoxicity in Sprague–Dawley Rats

Autor: Fernando Ramiro-Ibáñez, Amy H. Yang, Oscar Illanes, Dusko Trajkovic

Publikováno v: Toxicologic Pathology. 35:521-532

A model of para-aminophenol (PAP) nephrotoxicity in Sprague–Dawley rats was utilized to characterize potential indicators of toxicity in the kidney and in biofluids, and to chronicle the progression of acute renal injury. Rats were administered PAP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46053997820e8843e34c687cc1442ff8
https://doi.org/10.1080/01926230701338933

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Safety Considerations for Epigenetic Mechanisms as Drug Targets: Are Existing Toxicology Studies Fit for Purpose?

Autor: Amy H. Yang, Prashant R. Nambiar, Robert E. Chapin, Paul Butler, Mathew T. Pletcher, Brett D. Hollingshead, Karen Leach, Michael P. Lawton

Publikováno v: Epigenetics for Drug Discovery ISBN: 9781849738828

Epigenetic mechanisms have emerged as attractive therapeutic targets because of their pleiotropic role in diseases processes and the ability to pharmacologically modulate their activities. One key question in the safety assessment of epigenetic drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19aca5768438c022dba75b930160638f
https://doi.org/10.1039/9781782628484-00288

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Marked Perinatal Lethality and Cellular Signaling Deficits in Mice Null for the Two Sphingosine 1-Phosphate (S1P) Receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3

Autor: Isao Ishii, Amy H. Yang, Beth Friedman, Xiaoqin Ye, Guangfa Zhang, Shuji Kawamura, James J. A. Contos, Jerold Chun, Joan Heller Brown, Marcy A. Kingsbury

Publikováno v: Journal of Biological Chemistry. 277:25152-25159

Five cognate G protein-coupled receptors (S1P(1-5)) have been shown to mediate various cellular effects of sphingosine 1-phosphate (S1P). Here we report the generation of mice null for S1P(2) and for both S1P(2) and S1P(3). S1P(2)-null mice were viab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab083341b4697fcfad4b6f8859578f8c
https://doi.org/10.1074/jbc.m200137200

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In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice

Autor: Amy H. Yang, Jerold Chun, Isao Ishii

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1582:197-203

Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are extracellular ligands for a family of G protein-coupled receptors (GPCRs), LPA1/2/3 and S1P1/2/3/4/5. Through coupling to multiple classes of G proteins and activating multiple signali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac169d79a2d881adacdac86da838ca3
https://doi.org/10.1016/s1388-1981(02)00172-5

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RTP801 gene expression is differentially upregulated in retinopathy and is silenced by PF-04523655, a 19-Mer siRNA directed against RTP801

Autor: Paolo Vicini, Anthony S. Basile, Kay D. Rittenhouse, Amy H. Yang, Dalia Kalabat, Wenhu Huang, Brad Hirakawa, Theodore R. Johnson

Publikováno v: Investigative ophthalmologyvisual science. 55(3)

PURPOSE: The intraocular pharmacodynamics of PF-04523655, a small-interfering RNA (siRNA) directed against RTP801, was characterized using rat models of retinopathy. METHODS: Rat models of streptozotocin-induced diabetes and wet AMD were used to dete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf894d21d2b7acafa037b14fda607ec1
https://pubmed.ncbi.nlm.nih.gov/24458146

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