Brain Capillary Networks Across Species: A few Simple Organizational Requirements Are Sufficient to Reproduce Both Structure and Function

Autor: Amy F. Smith, Vincent Doyeux, Maxime Berg, Myriam Peyrounette, Mohammad Haft-Javaherian, Anne-Edith Larue, John H. Slater, Frédéric Lauwers, Pablo Blinder, Philbert Tsai, David Kleinfeld, Chris B. Schaffer, Nozomi Nishimura, Yohan Davit, Sylvie Lorthois

Publikováno v: Frontiers in Physiology, Vol 10 (2019)

Despite the key role of the capillaries in neurovascular function, a thorough characterization of cerebral capillary network properties is currently lacking. Here, we define a range of metrics (geometrical, topological, flow, mass transfer, and robus

Externí odkaz: https://doaj.org/article/5c6eea44e62e4684b2c3294c3d750b78

Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer's disease mouse models

Autor: Vincent Doyeux, Joan Zhou, Gabriel Otte, Victorine Muse, Maxime Berg, Marta Cortes-Canteli, Elizabeth M. Davenport, Oliver Bracko, Myriam Peyrounette, Laibaik Park, Costantino Iadecola, Mohammad Haft-Javaherian, Nozomi Nishimura, Jean C. Cruz Hernandez, Calvin J. Kersbergen, Chris B. Schaffer, Lindsay K. Vinarcsik, Sylvie Lorthois, Yiming Kang, Charles P. Lin, Yohan Davit, Daniel A. Rivera, Jeffrey D. Beverly, Amy F. Smith, Sidney Strickland, Iryna Ivasyk

Publikováno v: Nature neuroscience
Nature neuroscience, vol 22, iss 3
Nature Neuroscience
Nature Neuroscience, Nature Publishing Group, 2019, 22 (3), pp.413-420. ⟨10.1038/s41593-018-0329-4⟩

International audience; Cerebral blood flow (CBF) reductions in Alzheimer’s disease patients and related mouse models have been recognized for decades, but the underlying mechanisms and resulting consequences for Alzheimer’s disease pathogenesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a84e94333ebba91f7ccba9f445603c
https://pubmed.ncbi.nlm.nih.gov/30742116

Transmural Variation and Anisotropy of Microvascular Flow Conductivity in the Rat Myocardium

Autor: Gregory B. Sands, Amy F. Smith, Jack Lee, Rebecca J. Shipley, Ian J. LeGrice, Nicolas P. Smith

Publikováno v: Annals of Biomedical Engineering. 42:1966-1977

Transmural variations in the relationship between structural and fluid transport properties of myocardial capillary networks are determined via continuum modelling approaches using recent three-dimensional (3D) data on the microvascular structure. Sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30dc8875ab771d172e1962f59bf9acab
https://doi.org/10.1007/s10439-014-1028-2

Microvascular hemodynamics in the chick chorioallantoic membrane

Autor: Bianca Nitzsche, Axel R. Pries, Martin Maibier, Timothy W. Secomb, Amy F. Smith

Publikováno v: Microcirculation (New York, N.Y. : 1994). 23(7)

Objective The microvasculature of the chorioallantoic membrane (CAM) in the developing chick embryo is characterized by interdigitating arteriolar and venular trees, connected at multiple points along their lengths to a mesh-like capillary plexus. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f08eeadc719fe0de5a98621f179497af
https://pubmed.ncbi.nlm.nih.gov/27510444

Microvascular Hemodynamics in the Chick Chorioallantoic Membrane (CAM)

Autor: Bianca Nitzsche, Axel R. Pries, Amy F. Smith, Martin Maibier, Timothy W. Secomb

Publikováno v: The FASEB Journal. 29

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13700c64755fbabc34fb5cc017877d6d
https://doi.org/10.1096/fasebj.29.1_supplement.787.3