Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Amy F. Barabasz"'
1
Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90
Autor: Hanson Gunnar J, Philip F. Hughes, Barta Thomas E, Amy F. Barabasz, Briana Foley, James Marvin Veal, Jeffrey M. Partridge, Christopher John Markworth, Andy J. Ommen, Melanie Silinski, Steven E. Hall, John W. Rice, Paul M. Steed, Emilie D. Smith, Patrick Fadden, Kenneth He Huang, Wei Ma
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 22:2550-2554
A novel class of Hsp90 inhibitors, structurally distinct from previously reported scaffolds, was developed from rational design and optimization of a compound library screen hit. These aminoquinazoline derivatives, represented by compound 15 (SNX-683
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7762235091c8d574857ff8ee4a9462
https://doi.org/10.1016/j.bmcl.2012.01.137
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3
Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis
Autor: James Marvin Veal, Amy F. Barabasz, Jeffrey M. Partridge, Kenneth He Huang, John W. Rice, Melanie Silinski, Steven E. Hall, Barta Thomas E, Laura G. Dubois, Paul M. Steed, Patrick Fadden, Sarah R. Mabbett
Publikováno v: Arthritis & Rheumatism. 58:3765-3775
Objective. To evaluate the ability of SNX-7081, a novel small molecule inhibitor of Hsp90, to block components of inflammation, including cytokine production, protein kinase activity, and angiogenic signaling. A close analog was evaluated in preclini
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b5831e5060a3e02003575d5d1ddb12
https://doi.org/10.1002/art.24047
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4
The Use of High-Content Screening for the Discovery and Characterization of Compounds That Modulate Mitotic Index and Cell Cycle Progression by Differing Mechanisms of Action
Autor: Briana Foley, James C. Otto, Amy F. Barabasz, Anisa Scott, John W. Rice
Publikováno v: ASSAY and Drug Development Technologies. 4:153-163
The advent of high-content screening has expanded the ability of researchers to identify and quantify compound effects on a number of cellular events in a manner that allows for the rapid screening of chemical libraries. We have validated an approach
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5388e5482fd79ec323127b9121a1b2ea
https://doi.org/10.1089/adt.2006.4.153
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5
Novel carbazole and acyl-indole antimitotics
Autor: Barta Thomas E, Amy F. Barabasz, James Marvin Veal, Geng Lifeng, John W. Rice, Steven E. Hall, Hanson Gunnar J, Wei Ma, Briana Foley, Matthew Jenks
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:3078-3080
In the course of our Heat Shock 90 program, certain carbazole compounds were identified which had an off-target antiproliferative activity. To understand the off-target activity, we studied one analog with strong activity. We discovered that it had a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3702612cd01b55fabdb8614b9d1460f2
https://doi.org/10.1016/j.bmcl.2009.04.010
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6
Targeting of multiple signaling pathways by the Hsp90 inhibitor SNX-2112 in EGFR resistance models as a single agent or in combination with erlotinib
Autor: Amy F. Barabasz, James Marvin Veal, Paul M. Steed, Briana Foley, Ken Huang, Patrick Fadden, Steven E. Hall, Anisa Scott, John W. Rice
Publikováno v: Oncology research. 18(5-6)
Inhibition of Hsp90 has emerged as a therapeutic strategy to target NSCLC subtypes, which are refractory to epidermal growth factor receptor (EGFR) inhibitor-based treatment. We report on a novel small molecule inhibitor of Hsp90, SNX-2112, and an or
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83dc91c08d9f744d6dca391c289d727
https://pubmed.ncbi.nlm.nih.gov/20225761
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8
Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90
Autor: Geng Lifeng, James Marvin Veal, Jeffrey M. Partridge, Amy F. Barabasz, Steven E. Hall, James C. Otto, Barta Thomas E, Hanson Gunnar J, John W. Rice, Matthew Jenks, Wei Ma, Briana Foley, Patrick Fadden, Kenneth He Huang
Publikováno v: Bioorganicmedicinal chemistry letters. 18(12)
Hsp90 maintains the conformational stability of multiple proteins implicated in oncogenesis and has emerged as a target for chemotherapy. We report here the discovery of a novel small molecule scaffold that inhibits Hsp90. X-ray data show that the sc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f7c7cca52cc13617550beddfcf62d16
https://pubmed.ncbi.nlm.nih.gov/18511277
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