Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Amy E. Sutherland"'
Autor:
Amy E. Sutherland, Tegan A. White, Charmaine R. Rock, Beth R. Piscopo, Ingrid Dudink, Ishmael M. Inocencio, Zahrah Azman, Yen Pham, Ilias Nitsos, Atul Malhotra, Tamara Yawno, Graeme R. Polglase, Graham Jenkin, Emily J. Camm, Beth J. Allison, Suzanne L. Miller
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionFetal growth restriction (FGR) is a common pregnancy complication, caused by placental insufficiency, with serious adverse consequences for development in utero and postnatal wellbeing. There are no antenatal treatments to improve growth
Externí odkaz:
https://doaj.org/article/a7afa6dae9ba4286895b477cbdface19
Autor:
Arya Jithoo, Tayla R. Penny, Yen Pham, Amy E. Sutherland, Madeleine J. Smith, Maria Petraki, Michael C. Fahey, Graham Jenkin, Atul Malhotra, Suzanne L. Miller, Courtney A. McDonald
Publikováno v:
Cells, Vol 13, Iss 8, p 660 (2024)
Blood–brain barrier (BBB) dysfunction and neuroinflammation are key mechanisms of brain injury. We performed a time-course study following neonatal hypoxia–ischemia (HI) to characterize these events. HI brain injury was induced in postnatal day 1
Externí odkaz:
https://doaj.org/article/ecce5ed930b1429db87c22d2709ad9b5
Autor:
Alexander Bell, Ashalyn P. Watt, Ingrid Dudink, Yen Pham, Amy E. Sutherland, Beth J. Allison, Courtney A. McDonald, Margie Castillo-Melendez, Graham Jenkin, Atul Malhotra, Suzanne L. Miller, Tamara Yawno
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Background Fetal growth restriction (FGR) is associated with deficits in the developing brain, including neurovascular unit (NVU) dysfunction. Endothelial colony forming cells (ECFC) can mediate improved vascular stability, and have demonstr
Externí odkaz:
https://doaj.org/article/65981e6713c8487da827d96b797596ce
Autor:
Madeleine J. Smith, Tayla Penny, Yen Pham, Amy E. Sutherland, Graham Jenkin, Michael C. Fahey, Madison C. B. Paton, Megan Finch-Edmondson, Suzanne L. Miller, Courtney A. McDonald
Publikováno v:
Cells, Vol 12, Iss 22, p 2659 (2023)
(1) Background: Neonatal brain injury can lead to permanent neurodevelopmental impairments. Notably, suppressing inflammatory pathways may reduce damage. To determine the role of neuroinflammation in the progression of neonatal brain injury, we inves
Externí odkaz:
https://doaj.org/article/3d4c13f9aded4afa9e7aaa537e5ae941
Autor:
Tayla R. Penny, Yen Pham, Amy E. Sutherland, Joohyung Lee, Graham Jenkin, Michael C. Fahey, Suzanne L. Miller, Courtney A. McDonald
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Preclinical and clinical studies have shown that sex is a significant risk factor for perinatal morbidity and mortality, with males being more susceptible to neonatal hypoxic ischemic (HI) brain injury. No study has investigated sexual dimor
Externí odkaz:
https://doaj.org/article/265b40370d044d94b2afa0c170719093
Autor:
Atul Malhotra, Margie Castillo-Melendez, Beth J. Allison, Amy E. Sutherland, Ilias Nitsos, Yen Pham, Courtney A. McDonald, Michael C. Fahey, Graeme R. Polglase, Graham Jenkin, Suzanne L. Miller
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-14 (2020)
Abstract Background Neonatal ventilation exacerbates brain injury in lambs with fetal growth restriction (FGR), characterized by neuroinflammation and reduced blood-brain barrier integrity, which is normally maintained by the neurovascular unit. We e
Externí odkaz:
https://doaj.org/article/b7376f2b23fb4359b68a709e24402db5
Autor:
Amy E. Sutherland, Tamara Yawno, Margie Castillo-Melendez, Beth J. Allison, Atul Malhotra, Graeme R. Polglase, Leo J. Cooper, Graham Jenkin, Suzanne L. Miller
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Fetal growth restriction (FGR) is a common complication of pregnancy often associated with neurological impairments. Currently, there is no treatment for FGR, hence it is likely these babies will be delivered prematurely, thus being exposed to antena
Externí odkaz:
https://doaj.org/article/192566c5c38546e8b938582cc37bf2ac
Autor:
Beth J. Allison, Hannah Youn, Atul Malhotra, Courtney A. McDonald, Margie Castillo-Melendez, Yen Pham, Amy E. Sutherland, Graham Jenkin, Graeme R. Polglase, Suzanne L. Miller
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Fetal growth restriction (FGR) and prematurity are often co-morbidities, and both are risk factors for lung disease. Despite advances in early delivery combined with supportive ventilation, rates of ventilation-induced lung injury (VILI) remain high.
Externí odkaz:
https://doaj.org/article/a4005ec8f76840c89249abd975471373
Autor:
Courtney A. McDonald, Tayla R. Penny, Madison C. B. Paton, Amy E. Sutherland, Lakshmi Nekkanti, Tamara Yawno, Margie Castillo-Melendez, Michael C. Fahey, Nicole M. Jones, Graham Jenkin, Suzanne L. Miller
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-14 (2018)
Abstract Background It is well understood that hypoxic-ischemic (HI) brain injury during the highly vulnerable perinatal period can lead to cerebral palsy, the most prevalent cause of chronic disability in children. Recently, human clinical trials ha
Externí odkaz:
https://doaj.org/article/d1534264c6784b3585c9a919f9bba88b
Autor:
Charmaine R. Rock, Tegan A. White, Beth R. Piscopo, Amy E. Sutherland, Suzanne L. Miller, Emily J. Camm, Beth J. Allison
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7555 (2021)
Fetal growth restriction (FGR) is a common complication of pregnancy, resulting in a fetus that fails to reach its genetically determined growth potential. Whilst the fetal cardiovascular response to acute hypoxia is well established, the fetal defen
Externí odkaz:
https://doaj.org/article/2d01281a140b4bf69cb0667aad8cb7a5