Výsledky vyhledávání - "Amy E. Salyer"

Akademický článek

RyR2/IRBIT regulates insulin gene transcript, insulin content, and secretion in the insulinoma cell line INS-1

Autor: Kyle E. Harvey, Emily K. LaVigne, Mohd Saleem Dar, Amy E. Salyer, Evan P. S. Pratt, Paxton A. Sample, Uma K. Aryal, Humaira Gowher, Gregory H. Hockerman

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)

Abstract The role of ER Ca2+ release via ryanodine receptors (RyR) in pancreatic β-cell function is not well defined. Deletion of RyR2 from the rat insulinoma INS-1 (RyR2KO) enhanced IP3 receptor activity stimulated by 7.5 mM glucose, coincident wit

Externí odkaz: https://doaj.org/article/509d22267c154c8d8f7a4f3714bafb8a

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Akademický článek

Regulation of cAMP accumulation and activity by distinct phosphodiesterase subtypes in INS-1 cells and human pancreatic β-cells.

Autor: Evan P S Pratt, Kyle E Harvey, Amy E Salyer, Gregory H Hockerman

Publikováno v: PLoS ONE, Vol 14, Iss 8, p e0215188 (2019)

Pancreatic β-cells express multiple phosphodiesterase (PDE) subtypes, but the specific roles for each in β-cell function, particularly in humans, is not clear. We evaluated the cellular role of PDE1, PDE3, and PDE4 activity in the rat insulinoma ce

Externí odkaz: https://doaj.org/article/9b4be8e1aa4449a2ac7013bfa9238934

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RyR2/IRBIT regulates insulin gene transcription, insulin content, and secretion in the insulinoma cell line INS-1

Autor: Gregory H. Hockerman, Amy E. Salyer, Evan P.S. Pratt, P. A. Sample, Kyle E. Harvey, U. K. Aryal, E. K. LaVigne, H. Gowher, M. S. Dar

The role of ER Ca2+ release via ryanodine receptors (RyR) in pancreatic β-cell function is not well defined. Deletion of RyR2 from the rat insulinoma INS-1 (RyR2KO) enhanced the Ca2+ integral (AUC) stimulated by 7.5 mM glucose, and rendered it sensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c7af0485b64cc272e47e6a172f70457
https://doi.org/10.1101/2021.11.24.469894

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Regulation of cAMP accumulation and activity by distinct phosphodiesterase subtypes in INS-1 cells and human pancreatic β-cells

Autor: Gregory H. Hockerman, Evan P.S. Pratt, Shiqi Tang, Kyle E. Harvey, Amy E. Salyer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003bceb2a0b199dd18c00ae5fe86f464

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Agonists of the γ-Aminobutyric Acid Type B (GABA(B)) Receptor Derived from β-Hydroxy and β-Amino Difluoromethyl Ketones

Autor: Kuldeep K. Roy, Amy E. Salyer, David A. Colby, James R. Woods, Munia F. Sowaileh, Jinu P. John, Gregory H. Hockerman, Robert J. Doerksen

β-Hydroxy difluoromethyl ketones represent the newest class of agonists of the GABA-B receptor, and they are structurally distinct from all other known agonists at this receptor because they do not display the carboxylic acid or amino group of γ-am

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33eecdb9ba1015f79ff9d60d8caf5576
https://europepmc.org/articles/PMC6152937/

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Potentiation of Sulfonylurea Action by an EPAC-selective cAMP Analog in INS-1 Cells: Comparison of Tolbutamide and Gliclazide and a Potential Role for EPAC Activation of a 2-APB-sensitive Ca2+Influx

Autor: Marcy L. Guerra, Ian M. Soderling, Gregory H. Hockerman, Allison M. Lange, Yuchen Wang, Amy E. Salyer, Hilary J. Broderick, Evan P.S. Pratt, Rachel E. Jarrard

Publikováno v: Molecular Pharmacology. 83:191-205

Tolbutamide and gliclazide block the K(ATP) channel K(ir)6.2/Sur1, causing membrane depolarization and stimulating insulin secretion in pancreatic beta cells. We examined the ability of the EPAC-selective cAMP analog 8-pCPT-2'-O-Me-cAMP-AM to potenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576501f9fb161c362ab24e4e70cfecbb
https://doi.org/10.1124/mol.112.081943

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Ca2+ influx through L-type Ca2+ channels and Ca2+-induced Ca2+ release regulate cAMP accumulation and Epac1-dependent ERK 1/2 activation in INS-1 cells

Autor: Gregory H. Hockerman, Marcy L. Guerra, Evan P.S. Pratt, Amy E. Salyer

We previously reported that INS-1 cells expressing the intracellular II-III loop of the L-type Ca(2+) channel Cav1.2 (Cav1.2/II-III cells) are deficient in Ca(2+)-induced Ca(2+) release (CICR). Here we show that glucose-stimulated ERK 1/2 phosphoryla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daea80b3e4c804c5aa4b3df1207850d9
https://europepmc.org/articles/PMC4684454/

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