Výsledky vyhledávání - "Amy E. Rydeen"

Enhancing cytochrome P450-mediated non-natural cyclopropanation by mutation of a conserved second-shell residue

Autor: Joshua G. Gober, Timothy D. Schwochert, Evan J. Gibson-O'Grady, Eric M. Brustad, Amy E. Rydeen

Publikováno v: Biotechnology and Bioengineering. 115:1416-1426

Engineered cytochrome P450s are emerging as powerful synthetic tools due to their ability catalyze non-native metallocarbenoid and -nitrenoid insertion reactions. P450-mediated cyclopropanation has garnered particular interest due to the high selecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c65b8b593144a9263c53ace43608dc1
https://doi.org/10.1002/bit.26571

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Osmolytes and Protein-Protein Interactions

Autor: Eric M. Brustad, Gary J. Pielak, Amy E. Rydeen

Publikováno v: Journal of the American Chemical Society. 140(24)

Cells survive fluctuations in osmolality by accumulating and depleting highly soluble, usually neutral, small organic compounds. Natural selection has converged on a small set of such molecules, called osmolytes. The biophysical characterization of o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675826938aafe549095d9b8707bc243f
https://pubmed.ncbi.nlm.nih.gov/29842777

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Mutating a Highly Conserved Residue in Diverse Cytochrome P450s Facilitates Diastereoselective Olefin Cyclopropanation

Autor: Eric M. Brustad, Joshua G. Gober, Janelle B. Leuthaeuser, Amy E. Rydeen, Jacquelyn S. Fetrow, Evan J. Gibson-O'Grady

Publikováno v: Chembiochem : a European journal of chemical biology. 17(5)

Cytochrome P450s and other heme-containing proteins have recently been shown to have promiscuous activity for the cyclopropanation of olefins using diazoacetate reagents. Despite the progress made thus far, engineering selective catalysts for all pos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ccab47139e0e71c20e461b4abc9df6d
https://pubmed.ncbi.nlm.nih.gov/27805325

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