Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Amy E. O'Connell"'
Autor:
Amy E. O’Connell
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
Necrotizing enterocolitis (NEC) is a devastating disease of the neonatal intestine, causing widespread intestinal necrosis as well systemic illness that frequently results in death. Because the clinical onset of NEC is sudden and difficult to predict
Externí odkaz:
https://doaj.org/article/39e13c7fd18044e49667a7ca126e8d37
Autor:
Ahmed Abdelgawad, Teodora Nicola, Isaac Martin, Brian A. Halloran, Kosuke Tanaka, Comfort Y. Adegboye, Pankaj Jain, Changchun Ren, Charitharth V. Lal, Namasivayam Ambalavanan, Amy E. O’Connell, Tamás Jilling, Kent A. Willis
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract Background Mammalian mucosal barriers secrete antimicrobial peptides (AMPs) as critical, host-derived regulators of the microbiota. However, mechanisms that support microbiota homeostasis in response to inflammatory stimuli, such as supraphy
Externí odkaz:
https://doaj.org/article/f4008e535d694a91ab608755c7261389
Autor:
Amy E. O’Connell, Sathuwarman Raveenthiraraj, Luiz Fernando Silva Oliveira, Comfort Adegboye, Venkata Siva Dasuri, Wanshu Qi, Radhika S. Khetani, Akaljot Singh, Nambirajam Sundaram, Jasmine Lin, Prathima Nandivada, Lorena Rincón-Cruz, Jeffrey D. Goldsmith, Jay R. Thiagarajah, Diana L. Carlone, Jerrold R. Turner, Pankaj B. Agrawal, Michael Helmrath, David T. Breault
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 2, Pp 101349- (2024)
Background & aims: Humans with WNT2B deficiency have severe intestinal disease, including significant inflammatory injury, highlighting a critical role for WNT2B. We sought to understand how WNT2B contributes to intestinal homeostasis. Methods: We in
Externí odkaz:
https://doaj.org/article/73ecaa07cd064534a6b295fa2a02c92d
Autor:
Alexandra K. Blomfield, Meenakshi Maurya, Kiran Bora, Madeline C. Pavlovich, Felix Yemanyi, Shuo Huang, Zhongjie Fu, Amy E. O’Connell, Jing Chen
Publikováno v:
Cells, Vol 12, Iss 7, p 1033 (2023)
Wnt/β-catenin signaling is essential for embryonic eye development in both the anterior eye and retina. WNT2B, a ligand and activator of the Wnt/β-catenin pathway, assists in the development of the lens and peripheral regions of the eye. In humans
Externí odkaz:
https://doaj.org/article/e298992a6b8c423db48bbd093f3d6029
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Premature infants are known to have immature immune systems compared to term infants; however, the impacts of ex utero immune development are not well characterized. Our previous retrospective clinical review showed prolonged T cell lymphopenia in a
Externí odkaz:
https://doaj.org/article/16349313b90646c89cd6dc68bf9b1b1b
Autor:
Scott M. Gordon, Amy E. O’Connell
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Due to heightened awareness and advanced genetic tools, inborn errors of immunity (IEI) are increasingly recognized in children. However, diagnosing of IEI in premature infants is challenging and, subsequently, reports of IEI in premature infants rem
Externí odkaz:
https://doaj.org/article/3d50cac7915145aea67263e56b709397
Autor:
Amy E. O’Connell, Sathuwarman Raveenthiraraj, Comfort Adegboye, Wanshu Qi, Radhika S. Khetani, Akaljot Singh, Nambirajam Sundaram, Chidera Emeonye, Jasmine Lin, Jeffrey D. Goldsmith, Jay R. Thiagarajah, Diana L. Carlone, Jerrold R. Turner, Pankaj B. Agrawal, Michael Helmrath, David T. Breault
Publikováno v:
bioRxiv
Background and aimsWNT2B is a canonical Wnt ligand previously thought to be fully redundant with other Wnts in the intestinal epithelium. However, humans with WNT2B deficiency have severe intestinal disease, highlighting a critical role for WNT2B. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f32e2c49e942178dbaff1d00bcd608e
https://doi.org/10.1101/2023.04.21.537894
https://doi.org/10.1101/2023.04.21.537894
Autor:
Avery Forget, Comfort Adegboye, Maria Alfieri, Ramy Yim, Kathleen Flaherty, Himi Mathur, Amy E. O’Connell
Publikováno v:
Journal of Perinatology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b4dfb0735fb6137fe4e448501e0b521
https://doi.org/10.1038/s41372-023-01636-1
https://doi.org/10.1038/s41372-023-01636-1
Publikováno v:
Annals of Allergy, Asthma & Immunology. 124:589-593
Background Hypersensitivity reactions (HSRs) to tetracyclines and the related compound, tigecycline, can limit the use of these medications and compromise optimal patient care. Despite this, there is little discussion in the literature describing the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efb60a94a09ca4a08b2e72f13e3e0d07
https://doi.org/10.1016/j.anai.2020.02.007
https://doi.org/10.1016/j.anai.2020.02.007
Autor:
Amy E. O’Connell, Lauren C. Frazer
Publikováno v:
Pediatric research
Prematurity presents a diagnostic challenge in interpreting primary immunodeficiency (PID) testing.We retrospectively reviewed the charts of all infants in our level IV referral neonatal intensive care unit (NICU) in Massachusetts, with immunologic t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9423a2462d3a7a987961a26249846336
http://europepmc.org/articles/PMC8287644
http://europepmc.org/articles/PMC8287644