Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Amy E. Mercer"'
Autor:
Paul M. O’Neill, Richard K. Amewu, Susan A. Charman, Sunil Sabbani, Nina F. Gnädig, Judith Straimer, David A. Fidock, Emma R. Shore, Natalie L. Roberts, Michael H.-L. Wong, W. David Hong, Chandrakala Pidathala, Chris Riley, Ben Murphy, Ghaith Aljayyoussi, Francisco Javier Gamo, Laura Sanz, Janneth Rodrigues, Carolina Gonzalez Cortes, Esperanza Herreros, Iñigo Angulo-Barturén, María Belén Jiménez-Díaz, Santiago Ferrer Bazaga, María Santos Martínez-Martínez, Brice Campo, Raman Sharma, Eileen Ryan, David M. Shackleford, Simon Campbell, Dennis A. Smith, Grennady Wirjanata, Rintis Noviyanti, Ric N. Price, Jutta Marfurt, Michael J. Palmer, Ian M. Copple, Amy E. Mercer, Andrea Ruecker, Michael J. Delves, Robert E. Sinden, Peter Siegl, Jill Davies, Rosemary Rochford, Clemens H. M. Kocken, Anne-Marie Zeeman, Gemma L. Nixon, Giancarlo A. Biagini, Stephen A. Ward
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Artemisinin-resistantPlasmodium is an increasing problem. Here, using a medicinal chemistry programme, the authors identify a tetraoxane-based drug candidate that shows no cross-resistance with an artemisinin-resistant strain (PfK13-C580Y) and is eff
Externí odkaz:
https://doaj.org/article/d0b09995908d4fd1a466aa398f702f2f
Publikováno v:
Journal of Biological Chemistry; Vol 286
The artemisinin compounds are the frontline drugs for the treatment of drug-resistant malaria. They are selectively cytotoxic to mammalian cancer cell lines and have been implicated as neurotoxic and embryotoxic in animal studies. The endoperoxide fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2608103f9857e946ba6abeacedae6043
https://doi.org/10.1074/jbc.m110.144188
https://doi.org/10.1074/jbc.m110.144188
Autor:
B. Kevin Park, Charlotte Hirst, Craig Benson, Emma E. Graham, Amy E. Mercer, Dominic P. Williams, John R. Foster, Daniel J. Antoine, Sophie L. Regan, J. Gerry Kenna
Publikováno v:
Toxicology and Applied Pharmacology. 239:297-305
Methapyrilene, [N,N-dimethyl-N'-pyridyl-N'(2-thienylmethyl)-1,2-ethanediamine] (MP) was withdrawn from, clinical use due to reported periportal hepatic necrosis and hepatocarcinogenicity in the rat, via S-oxidation of the thiophene group. In this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bab60abc395af53fe0eeb5c7fda7d5e
https://doi.org/10.1016/j.taap.2009.05.027
https://doi.org/10.1016/j.taap.2009.05.027
Publikováno v:
Xenobiotica. 39:565-577
Adverse drug reactions, in particular drug-induced hepatotoxicity, represent a major challenge for clinicians and an impediment to safe drug development. Novel blood or urinary biomarkers of chemically-induced hepatic stress also hold great potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86cb5a37c4a8a83021aaf332023b6a8
https://doi.org/10.1080/00498250903046993
https://doi.org/10.1080/00498250903046993
Autor:
Jill Davies, Tafadzwa Charidza, Miriam E. Kennedy, B. Kevin Park, Amy E. Mercer, Ivo Piantanida, Michael Jones, Paul M. O'Neill, Jonathan Baird, Omar Janneh, Patrick G. Bray, Richard Cosstick, Paul A. Stocks, Sarah L. Rawe, Stephen A. Ward, Louise La Pensee
Publikováno v:
Articles
Artemisinin-acridine hybrids were prepared and evaluated for their in vitro activity against tumour cell lines and a chloroquine sensitive strain of Plasmodium falciparum. They showed a 2-4-fold increase in activity against HL60, MDA-MB-231 and MCF-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16dfc301f102ae95bee6407f88e87303
https://doi.org/10.1016/j.bmcl.2009.02.028
https://doi.org/10.1016/j.bmcl.2009.02.028
Autor:
Paul A. Stocks, Patrick G. Bray, Victoria E. Barton, Mohammed Al-Helal, Michael Jones, Nuna C. Araujo, Peter Gibbons, Stephen A. Ward, Ruth H. Hughes, Giancarlo A. Biagini, Jill Davies, Richard Amewu, Amy E. Mercer, Gemma Ellis, Paul M. O'Neill
Publikováno v:
Angewandte Chemie. 119:6394-6399
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34ae1027b50288ebb6634c307010d99a
https://doi.org/10.1002/ange.200604697
https://doi.org/10.1002/ange.200604697
Autor:
Amy E. Mercer, James Chadwick, Paul M. O'Neill, Xiao-Ming Sun, B. Kevin Park, James L. Maggs, Gerald M. Cohen
Publikováno v:
Journal of Biological Chemistry. 282:9372-9382
Artemisinin and its derivatives are currently recommended as first-line antimalarials in regions where Plasmodium falciparum is resistant to traditional drugs. The cytotoxic activity of these endoperoxides toward rapidly dividing human carcinoma cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809b9a928acaf968e9d4d42775bd403f
https://doi.org/10.1074/jbc.m610375200
https://doi.org/10.1074/jbc.m610375200
Publikováno v:
Expert Opinion on Therapeutic Patents. 16:1665-1672
The recent scientific and patent literature on therapeutically promising anticancer trioxanes derived from the antimalarial artemisinin are reviewed through mid-2006. Several of these new chemical entities, especially some trioxane dimers, have selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a240586bf2d6ee657d8f6fedf6bcbda3
https://doi.org/10.1517/13543776.16.12.1665
https://doi.org/10.1517/13543776.16.12.1665
Autor:
J Prince Jeyadevan, Jill Davies, Dominic P. Williams, James Chadwick, Rick Cosstick, Amy E. Mercer, Patrick G. Bray, Gary H Posner, Ed Irving, Paul M. O'Neill, Stephen A. Ward, B. Kevin Park, Aoife Byrne, Adrian Peter Higson
Publikováno v:
Journal of Medicinal Chemistry. 47:1290-1298
Four series of C-10 non-acetal dimers were prepared from key trioxane alcohol 10beta-(2-hydroxyethyl)deoxoartemisinin (9b). All of the dimers prepared displayed potent low nanomolar antimalarial activity versus the K1 and HB3 strains of Plasmodium fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca1e805ff5f47765538d782927df36d
https://doi.org/10.1021/jm030974c
https://doi.org/10.1021/jm030974c
Autor:
Paul M. O'Neill, Michael H. L. Wong, Ian M. Copple, James Chadwick, B. Kevin Park, James W. Firman, Bob van de Water, Stephen A. Ward, Maria Lurdes Santos Cristiano, Bram Herpers, Andreia D. Bringela, G. Donegan, Amy E. Mercer
Publikováno v:
Molecular Medicine; Vol 18
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Semisynthetic artemisinin-based therapies are the first-line treatment for P. falciparum malaria, but next-generation synthetic drug candidates are urgently required to improve availability and respond to the emergence of artemisinin-resistant parasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23432657bec406f44adf1da544475d9
https://pubmed.ncbi.nlm.nih.gov/22669474
https://pubmed.ncbi.nlm.nih.gov/22669474