The BASP1 transcriptional corepressor modifies chromatin through lipid-dependent and lipid-independent mechanisms

Autor: Alexander J. Moorhouse, Amy E. Loats, Kathryn F. Medler, Stefan G.E. Roberts

Publikováno v: iScience, Vol 25, Iss 8, Pp 104796- (2022)

Summary: The transcriptional corepressor BASP1 requires N-terminal myristoylation for its activity and functions through interactions with nuclear lipids. Here we determine the role of BASP1 lipidation in histone modification and the modulation of ch

Externí odkaz: https://doaj.org/article/33f7b2143b3442deb9ca641f850b4e4f

Cholesterol is required for transcriptional repression by BASP1

Autor: Kathryn F. Medler, Eneda Toska, Abigail R.E. Roberts, Alice Sherrard, Samantha Carrera, Alex Moorhouse, Anna F. Fleming, Stefan G. E. Roberts, Amy E. Loats

Publikováno v: Dey, A E, Carrera, S, Fleming, A F, Roberts, A, Sherrard, A, Toska, E, Moorhouse, A, Medler, K F & Roberts, S G E 2021, ' Cholesterol is required for transcriptional repression by BASP1 ', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 29, e2101671118 . https://doi.org/10.1073/pnas.2101671118
Proceedings of the National Academy of Sciences of the United States of America

Significance Cholesterol is present within the cell nucleus, where it associates with chromatin, but to date, a direct role for cholesterol in nuclear processes has not been identified. We demonstrate that the transcriptional repressor brain acid sol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e2057be7e9a4b208415b348770c8a2
https://doi.org/10.1073/pnas.2101671118