Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Amy E. Lin"'
Autor:
Rob S. Sellar, Adam S. Sperling, Mikołaj Słabicki, Jessica A. Gasser, Marie E. McConkey, Katherine A. Donovan, Nada Mageed, Dylan N. Adams, Charles Zou, Peter G. Miller, Ravi K. Dutta, Steffen Boettcher, Amy E. Lin, Brittany Sandoval, Vanessa A. Quevedo Barrios, Veronica Kovalcik, Jonas Koeppel, Elizabeth K. Henderson, Emma C. Fink, Lu Yang, Anthony Chan, Sheela Pangeni Pokharel, Erik J. Bergstrom, Rajan Burt, Namrata D. Udeshi, Steven A. Carr, Eric S. Fischer, Chun-Wei Chen, Benjamin L. Ebert
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 16 (2022)
Targeted protein degradation is a rapidly advancing and expanding therapeutic approach. Drugs that degrade GSPT1 via the CRL4CRBN ubiquitin ligase are a new class of cancer therapy in active clinical development with evidence of activity against acut
Externí odkaz:
https://doaj.org/article/81fae13f3404407c97508eb3a6337c9d
Publikováno v:
Annual Review of Cancer Biology. 6:187-200
Clonal hematopoiesis of indeterminate potential (CHIP) is a state in which somatic mutations in hematopoietic stem cells lead to clonal expansion of blood cells in individuals without hematologic malignancy. The mutated genes, including TET2, DNMT3A,
Autor:
Aditya Bharatha, Amy E. Lin, Mario A. Ostrowski, Suradech Suthiphosuwan, Ryan T. Muir, Raphael Schneider, David G. Munoz
Publikováno v:
Journal of Neuropathology and Experimental Neurology
Autor:
Mridul Agrawal, Abhishek Niroula, Pierre Cunin, Marie McConkey, Veronica Shkolnik, Peter G. Kim, Waihay J. Wong, Lachelle D. Weeks, Amy E. Lin, Peter G. Miller, Christopher J. Gibson, Aswin Sekar, Inga-Marie Schaefer, Donna Neuberg, Richard M. Stone, Alexander G. Bick, Md Mesbah Uddin, Gabriel K. Griffin, Siddhartha Jaiswal, Pradeep Natarajan, Peter A. Nigrovic, Deepak A. Rao, Benjamin L. Ebert
Publikováno v:
Blood. 140(10)
Gout is a common inflammatory arthritis caused by precipitation of monosodium urate (MSU) crystals in individuals with hyperuricemia. Acute flares are accompanied by secretion of proinflammatory cytokines, including interleukin-1β (IL-1β). Clonal h
Autor:
Benjamin L. Ebert, David M. Evans, Mridul Agrawal, Veronica Shkolnik, Douglas P. Kiel, Christopher J. Gibson, Marie McConkey, Mesbah Uddin, Wesley J. Shin, Abhishek Niroula, Drew N. Cohen, James P. Pirruccello, Pradeep Natarajan, Mikolaj Slabicki, Mary L. Bouxsein, Alexander G. Bick, Waihay J. Wong, Gabriel K. Griffin, Daniel J. Brooks, Peter Geon Kim, Aswin Sekar, Julia F. Charles, J. Brent Richards, Amy E. Lin, Jonathan M. Tsai, Marc N. Wein, John P. Kemp, Siddhartha Jaiswal
Publikováno v:
The Journal of experimental medicine. 218(12)
Osteoporosis is caused by an imbalance of osteoclasts and osteoblasts, occurring in close proximity to hematopoietic cells in the bone marrow. Recurrent somatic mutations that lead to an expanded population of mutant blood cells is termed clonal hema
Autor:
Noah Ditkofsky, Suradech Suthiphosuwan, Aditya Bharatha, Hojjat Salehinejad, Errol Colak, Jumpei Kitamura, Amy E. Lin, Muhammad Mamdani, Hui-Ming Lin, Jefferson R. Wilson
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Machine learning (ML) holds great promise in transforming healthcare. While published studies have shown the utility of ML models in interpreting medical imaging examinations, these are often evaluated under laboratory settings. The importance of rea
Autor:
David P. Steensma, Ross L. Levine, Javid Moslehi, Dipti Gupta, Kelly L. Bolton, Christian Schulz, Ron Blankstein, Andreas M. Zeiher, Benjamin L. Ebert, Lee W. Jones, Amy E. Lin, Robert Sidlow, Peter Libby, Siddhartha Jaiswal
Publikováno v:
Journal of the American College of Cardiology. 74:567-577
A novel, common, and potent cardiovascular risk factor has recently emerged: clonal hematopoiesis of indeterminate potential (CHIP). CHIP arises from somatic mutations in hematopoietic stem cells that yield clonal progeny of mutant leukocytes in bloo
Publikováno v:
European Heart Journal
Aims Clonal haematopoiesis of indeterminate potential (CHIP), defined as the presence of an expanded somatic blood cell clone without other haematological abnormalities, was recently shown to increase with age and is associated with coronary artery d
Autor:
Mridul Agrawal, Marie McConkey, Peter Miller, Pradeep Natarajan, Deepak A. Rao, Donna Neuberg, Christopher J. Gibson, Abhishek Niroula, Benjamin L. Ebert, Alexander G. Bick, Aswin Sekar, Waihay J. Wong, Amy E. Lin, Peter Geon Kim, Lachelle D. Weeks, Pierre Cunin, Peter A. Nigrovic
Publikováno v:
Blood. 138:595-595
Background: Gout is a highly prevalent arthritis associated with debilitating joint pain and functional impairment. It is caused by elevated serum uric acid levels (hyperuricemia) and triggered by precipitation of urate crystals in and around joints.
Autor:
Kelly Tai, Mitchell G. Vainberg, Tak W. Mak, Han You, Josef M. Penninger, Michael E. Parsons, James R. Woodgett, Amy E. Lin, Sara R. Hamilton, Kristine M. Garza, Karl S. Lang, Alisha R. Elford, Kip Wigmore, Charles W. Tran, Thierry Le Bihan, Samuel D. Saibil, Pamela S. Ohashi
Publikováno v:
The Journal of Immunology. 199:4056-4065
The decision between T cell activation and tolerance is governed by the spatial and temporal integration of diverse molecular signals and events occurring downstream of TCR and costimulatory or coinhibitory receptor engagement. The PI3K–protein kin