Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Amy E. Ikui"'
Autor:
Jasmin Philip, Mihkel Örd, Andriele Silva, Shaneen Singh, John FX Diffley, Dirk Remus, Mart Loog, Amy E Ikui
Publikováno v:
eLife, Vol 11 (2022)
Cdc6, a subunit of the pre-replicative complex (pre-RC), contains multiple regulatory cyclin-dependent kinase (Cdk1) consensus sites, SP or TP motifs. In Saccharomyces cerevisiae, Cdk1 phosphorylates Cdc6-T7 to recruit Cks1, the Cdk1 phospho-adaptor
Externí odkaz:
https://doaj.org/article/e70ef1cf97474ef78ed6b80699e78c6c
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009471 (2021)
DNA replication is fundamental to all living organisms. In yeast and animals, it is triggered by an assembly of pre-replicative complex including ORC, CDC6 and MCMs. Cyclin Dependent Kinase (CDK) regulates both assembly and firing of the pre-replicat
Externí odkaz:
https://doaj.org/article/11ee82d39acd4b1090d3ba6ed737a175
Autor:
Lea Schroeder, Amy E Ikui
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0199484 (2019)
Sodium dodecyl sulfate is a detergent that disrupts cell membranes, activates cell wall integrity signaling and restricts cell growth in Saccharomyces cerevisiae. However, the underlying mechanism of how sodium dodecyl sulfate inhibits cell growth is
Externí odkaz:
https://doaj.org/article/5f19c29c345540ef8d01d401bb414a59
Autor:
Jasmin, Philip, Mihkel, Örd, Andriele, Silva, Shaneen, Singh, John Fx, Diffley, Dirk, Remus, Mart, Loog, Amy E, Ikui
Publikováno v:
eLife. 11
Cdc6, a subunit of the pre-replicative complex (pre-RC), contains multiple regulatory cyclin-dependent kinase (Cdk1) consensus sites, SP or TP motifs. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cdb8c0f109f88cdc734d7b3cf2342ac3
https://pubmed.ncbi.nlm.nih.gov/35142288
https://pubmed.ncbi.nlm.nih.gov/35142288
Autor:
Shoily Khondker, Amy E. Ikui
The cell cycle is an ordered process in which cells replicate their DNA in S-phase and divide them into two identical daughter cells in mitosis. DNA replication takes place only once per cell cycle to preserve genome integrity, which is tightly regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afd50ac44c52634a4794d23eb8b1f0ab
https://doi.org/10.1101/2020.08.27.269696
https://doi.org/10.1101/2020.08.27.269696
Autor:
Jan M. Skotheim, Shoily Khondker, Sam Kajjo, Devon Chandler-Brown, Amy E. Ikui, Adam D. Rudner
Publikováno v:
J Cell Sci
PP2ACdc55 (the form of protein phosphatase 2A containing Cdc55) regulates cell cycle progression by reversing cyclin-dependent kinase (CDK)- and polo-like kinase (Cdc5)-dependent phosphorylation events. In S. cerevisiae, Cdk1 phosphorylates securin (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308003bf3eff9350c0d5f6e81fc7bac3
https://europepmc.org/articles/PMC7406319/
https://europepmc.org/articles/PMC7406319/
We recently isolated temperature-sensitive cell cycle mutants inChlamydomonas reinhardtiifor which the causative mutations were located in genes annotated for potential involvement in DNA replication.Chlamydomonashas a very long G1 period during whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75be40be8de1abc1172748f3b51c6485
Publikováno v:
PLoS Genetics, Vol 8, Iss 12, p e1003099 (2012)
Cdc6p is an essential component of the pre-replicative complex (pre-RC), which binds to DNA replication origins to promote initiation of DNA replication. Only once per cell cycle does DNA replication take place. After initiation, the pre-RC component
Externí odkaz:
https://doaj.org/article/885ee8b9ed474198b1051671ed3a403e
Autor:
Amy E. Ikui, Jan M. Skotheim, Shoily Khondker, Sam Kajjo, Devon Chandler-Brown, Adam D. Rudner
DNA replication stress stalls replication forks leading to chromosome breakage and Intra-S checkpoint activation. InS. cerevisiae, this checkpoint arrests the cell cycle by stabilizing securin (Pds1) and inhibiting the cyclin dependent kinase (CDK) t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a851c0ddd39536265475e1eb4a4b2057