Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Amy E. Howell"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Genetic evidence suggests glioma risk is altered by leukocyte telomere length, allergic disease (asthma, hay fever or eczema), alcohol consumption, childhood obesity, low-density lipoprotein cholesterol (LDLc) and triglyceride levels. DNA me
Externí odkaz:
https://doaj.org/article/ec7ee2d8b5e54f4fa9c496cf602a9ee1
Autor:
Jamie W. Robinson, Richard M. Martin, Spiridon Tsavachidis, Amy E. Howell, Caroline L. Relton, Georgina N. Armstrong, Melissa Bondy, Jie Zheng, Kathreena M. Kurian
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Genome-wide association studies (GWAS) have discovered 27 loci associated with glioma risk. Whether these loci are causally implicated in glioma risk, and how risk differs across tissues, has yet to be systematically explored. We integrated
Externí odkaz:
https://doaj.org/article/671b6767142d465a88df9af27c9c410a
Autor:
Tamsin H. Sharp, Nancy S. McBride, Amy E. Howell, C. John Evans, Derek K. Jones, Gavin Perry, Stavros I. Dimitriadis, Thomas M. Lancaster, Luisa Zuccolo, Caroline Relton, Sarah M. Matthews, Thomas Breeze, Anthony S. David, Mark Drakesmith, David E. J. Linden, Tomas Paus, Esther Walton
Publikováno v:
Wellcome Open Research, Vol 5 (2020)
Neuroimaging offers a valuable insight into human brain development by allowing in vivo assessment of structure, connectivity and function. Multimodal neuroimaging data have been obtained as part of three sub-studies within the Avon Longitudinal Stud
Externí odkaz:
https://doaj.org/article/549896ca42b0487c9cc13bdda77fe848
Autor:
Hong Zhang, Humaira Rasheed, Yukinori Okada, Iona Y Millwood, Zhengming Chen, Tom R. Gaunt, George Davey Smith, Yoichiro Kamatani, Venexia M Walker, Philip C Haycock, Andrew P. Morris, Jie Zheng, Cristian Pattaro, Robyn E Wootton, Yuka Sugawara, Amy E Howell, Masato Akiyama, Koichi Matsuda, Sean J. Barbour, Nora Franceschini, Masahiro Kanai, Matthias Wuttke, Si Fang, Masayuki Yamamoto, Jiachen Li, Naoki Kashihara, Ben Michael Brumpton, Laurent F. Thomas, Maria Carolina Borges, Rebecca Carnegie, Jamie Robinson, Yue-miao Zhang, Stein Hallan, Canqing Yu, Benjamin Elsworth, Stephen Burgess, Yue Leng, Kristian Hveem, Robin G Walters, Yoonsu Cho, Anna Köttgen, Bjørn Olav Åsvold, Qian Yang
Publikováno v:
Zheng, J, Zhang, Y, Rasheed, H, Walker, V M, Sugawara, Y, Li, J, Leng, Y, Elsworth, B L, Wootton, R E, Fang, S, Yang, Q, Burgess, S, Haycock, P C, Borges, M C, Cho, Y, Carnegie, R, Howell, A E, Robinson, J W, Thomas, L, Brumpton, B M, Hveem, K, Hallan, S, Franceschini, N, Morris, A, Köttgen, A, Pattaro, C, Wuttke, M, Yamamoto, M, Kashihara, N, Akiyama, M, Kanai, M, Matsuda, K, Kamatani, Y, Okada, Y, Walters, R, Millwood, I, Chen, Z, Davey Smith, G, Barbour, S, Yu, C, Åsvold, B O, Zhang, H & Gaunt, T R 2021, ' Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease ', International Journal of Epidemiology, vol. 50, no. 6, pp. 1995-2010 . https://doi.org/10.1093/ije/dyab203
International Journal of Epidemiology
International Journal of Epidemiology
Funder: Government Department of Business
Funder: Energy and Industrial Strategy (BEIS)
Funder: Vice-Chancellor Fellowship from the University of Bristol
Funder: Shanghai Thousand Talents Program
Funder: Academy of Medical Science
Funder: Energy and Industrial Strategy (BEIS)
Funder: Vice-Chancellor Fellowship from the University of Bristol
Funder: Shanghai Thousand Talents Program
Funder: Academy of Medical Science
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ad61d2f9c0bf562a39300875218aa6
https://research-information.bris.ac.uk/ws/files/312545151/dyab203.pdf
https://research-information.bris.ac.uk/ws/files/312545151/dyab203.pdf
Autor:
Claire Kelly, Ashleigh Kernohan, Julian P T Higgins, Francesca Spiga, Christopher Wragg, Lena Schmidt, Alexandra McAleenan, Luke Vale, Sarah Jefferies, Kathreena M Kurian, Claire Faulkner, Sarah Dawson, Amy E Howell, Hung-Yuan Cheng, Sebastian Brandner, Tomas Robinson
Publikováno v:
Cochrane Database Syst Rev
Mcaleenan, A S J, Kelly, C J, Spiga, F, Kernohan, A, Cheng, H-Y, Dawson, S, Schmidt, L, Robinson, T, Brandner, S, Faulkner, C, Wragg, C, Jefferies, S, Howell, A E, Vale, L, Higgins, J P T & Kurian, K M 2021, ' Prognostic value of test(s) for O6-methylguanine–DNA methyltransferase (MGMT) promoter methylation for predicting overall survival in people with glioblastoma treated with temozolomide ', Cochrane Database of Systematic Reviews, vol. 2021, no. 3, CD013316 . https://doi.org/10.1002/14651858.CD013316.pub2
Mcaleenan, A S J, Kelly, C J, Spiga, F, Kernohan, A, Cheng, H-Y, Dawson, S, Schmidt, L, Robinson, T, Brandner, S, Faulkner, C, Wragg, C, Jefferies, S, Howell, A E, Vale, L, Higgins, J P T & Kurian, K M 2021, ' Prognostic value of test(s) for O6-methylguanine–DNA methyltransferase (MGMT) promoter methylation for predicting overall survival in people with glioblastoma treated with temozolomide ', Cochrane Database of Systematic Reviews, vol. 2021, no. 3, CD013316 . https://doi.org/10.1002/14651858.CD013316.pub2
Background: Glioblastoma is an aggressive form of brain cancer. Approximately five in 100 people with glioblastoma survive for five years past diagnosis. Glioblastomas that have a particular modification to their DNA (called methylation) in a particu
Autor:
Kathreena M Kurian, Melissa L. Bondy, Jamie Robinson, Georgina Armstrong, Richard M. Martin, Amy E Howell, Spiridon Tsavachidis, Jie Zheng, Caroline L Relton
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Robinson, J W, Martin, R M, Howell, A E, Relton, C L, Zheng, J & Kurian, K M 2021, ' Transcriptome-wide Mendelian randomization study prioritising novel tissue-dependent genes for glioma susceptibility ', Scientific Reports, vol. 11, no. 1, 2329 . https://doi.org/10.1038/s41598-021-82169-5
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Robinson, J W, Martin, R M, Howell, A E, Relton, C L, Zheng, J & Kurian, K M 2021, ' Transcriptome-wide Mendelian randomization study prioritising novel tissue-dependent genes for glioma susceptibility ', Scientific Reports, vol. 11, no. 1, 2329 . https://doi.org/10.1038/s41598-021-82169-5
Genome-wide association studies (GWAS) have discovered 27 loci associated with glioma risk. Whether these loci are causally implicated in glioma risk, and how risk differs across tissues, has yet to be systematically explored. We integrated multi-tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb83eddd17a781718aae1d1edac53f79
https://doi.org/10.1101/2020.10.12.335661
https://doi.org/10.1101/2020.10.12.335661
Autor:
Masayuki Yamamoto, Yukinori Okada, Guang Ning, Sean J. Barbour, Qian Yang, Tom R. Gaunt, Nora Franceschini, P Haycock, Yajuan Zhang, Kenji Matsuda, Stein Hallan, Masahiro Kanai, Venexia M Walker, Matthias Wuttke, Jie Zheng, Cristian Pattaro, Chi-Sou Yu, Yoichiro Kamatani, Si Fang, Haiying Zhang, M. Xu, Amy E Howell, Masato Akiyama, Jbl Robinson, Humaira Rasheed, Stuart C Burgess, Robyn E Wootton, Bjørn Olav Åsvold, Jianping Li, Anna Köttgen, Yuka Sugawara, Yue Leng, Kristian Hveem, Benjamin Elsworth, Andrew P. Morris, Yoonsu Cho, Rebecca Carnegie, Yanxia Bi, Naoki Kashihara, Ben Michael Brumpton, Laurent F. Thomas, Maria Carolina Borges, G Davey Smith
BACKGROUNDThe chronic kidney disease (CKD) public health burden is substantial and has not declined as expected with current interventions on disease treatments. A large number of clinical, biological, and behavioural risk factors have been associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6f9975d5f9cab712825592fb73d6be4
https://doi.org/10.1101/2020.09.04.20188284
https://doi.org/10.1101/2020.09.04.20188284
Autor:
Caroline L Relton, Jie Zheng, Melissa Bondy, Robyn E Wootton, Quinn T. Ostrom, P Haycock, Spyros Tsavachidis, Amy E Howell, Kathreena M Kurian, Jamie Robinson, Richard M. Martin, Alexandra McAleenan, Georgina Armstrong
Publikováno v:
BMC Cancer
BMC Cancer, Vol 20, Iss 1, Pp 1-11 (2020)
Howell, A E, Robinson, J W, Wootton, R E, McAleenan, A, Tsavachidis, S, Ostrom, Q T, Bondy, M, Armstrong, G, Relton, C, Haycock, P, Martin, R M, Zheng, J & Kurian, K M 2020, ' Testing for causality between systematically identified risk factors and glioma : A Mendelian randomization study ', BMC Cancer, vol. (2020) 20, no. 508 . https://doi.org/10.1186/s12885-020-06967-2
BMC Cancer, Vol 20, Iss 1, Pp 1-11 (2020)
Howell, A E, Robinson, J W, Wootton, R E, McAleenan, A, Tsavachidis, S, Ostrom, Q T, Bondy, M, Armstrong, G, Relton, C, Haycock, P, Martin, R M, Zheng, J & Kurian, K M 2020, ' Testing for causality between systematically identified risk factors and glioma : A Mendelian randomization study ', BMC Cancer, vol. (2020) 20, no. 508 . https://doi.org/10.1186/s12885-020-06967-2
Background Whilst epidemiological studies have provided evidence of associations between certain risk factors and glioma onset, inferring causality has proven challenging. Using Mendelian randomization (MR), we assessed whether associations of 36 rep
Autor:
Jie Zheng, Kathreena M Kurian, Amy E Howell, Philip C Haycock, Caroline L Relton, Richard M. Martin, Alexandra McAleenan
Publikováno v:
Howell, A, Zheng, J, Haycock, P, McAleenan, A, Relton, C, Martin, R & Kurian, K 2018, ' Use of Mendelian Randomization for Identifying Risk Factors for Brain Tumors ', Frontiers in Genetics, vol. 9, 525 . https://doi.org/10.3389/fgene.2018.00525
Frontiers in Genetics
Frontiers in Genetics, Vol 9 (2018)
Frontiers in Genetics
Frontiers in Genetics, Vol 9 (2018)
Gliomas are a group of primary brain tumors, the most common and aggressive subtype of which is glioblastoma. Glioblastoma has a median survival of just 15 months after diagnosis. Only previous exposure to ionizing radiation and particular inherited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e30d2970fdf1423a9c752015aea6e25
https://research-information.bris.ac.uk/en/publications/f39957de-cc8b-4a0a-958f-0ba182c770ab
https://research-information.bris.ac.uk/en/publications/f39957de-cc8b-4a0a-958f-0ba182c770ab
Autor:
Stavros I. Dimitriadis, Sarah Matthews, Esther Walton, Tamsin H Sharp, Tomáš Paus, Caroline L Relton, Nancy McBride, Anthony S. David, Derek K. Jones, David Edmund Johannes Linden, Thomas Breeze, Luisa Zuccolo, Thomas M. Lancaster, Amy E Howell, Mark Drakesmith, C. John Evans, Gavin Perry
Publikováno v:
Sharp, T H, McBride, N S, Howell, A E, Evans, C J, Jones, D K, Perry, G, Dimitriadis, S I, Lancaster, T M, Zuccolo, L, Relton, C, Matthews, S M, Breeze, T, David, A S, Drakesmith, M, Linden, D E J, Paus, T & Walton, E 2020, ' Population neuroimaging : generation of a comprehensive data resource within the ALSPAC pregnancy and birth cohort ', Wellcome Open Research . https://doi.org/10.12688/wellcomeopenres.16060.1
Wellcome Open Research
Sharp, T H, McBride, N S, Howell, A E, Evans, C J, Jones, D K, Perry, G, Dimitriadis, S I, Lancaster, T M, Zuccolo, L, Relton, C, Matthews, S M, Breeze, T, David, A S, Drakesmith, M, Linden, D E J, Paus, T & Walton, E 2020, ' Population neuroimaging : generation of a comprehensive data resource within the ALSPAC pregnancy and birth cohort ', Wellcome Open Research, vol. 5, 203 . https://doi.org/10.12688/wellcomeopenres.16060.1
Wellcome Open Research
Sharp, T H, McBride, N S, Howell, A E, Evans, C J, Jones, D K, Perry, G, Dimitriadis, S I, Lancaster, T M, Zuccolo, L, Relton, C, Matthews, S M, Breeze, T, David, A S, Drakesmith, M, Linden, D E J, Paus, T & Walton, E 2020, ' Population neuroimaging : generation of a comprehensive data resource within the ALSPAC pregnancy and birth cohort ', Wellcome Open Research, vol. 5, 203 . https://doi.org/10.12688/wellcomeopenres.16060.1
Neuroimaging offers a valuable insight into human brain development by allowing in vivo assessment of structure, connectivity and function. Multimodal neuroimaging data have been obtained as part of three sub-studies within the Avon Longitudinal Stud