Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Amy E. Ghiretti"'
Autor:
Mary Muhia, Edda Thies, Dorthe Labonté, Amy E. Ghiretti, Kira V. Gromova, Francesca Xompero, Corinna Lappe-Siefke, Irm Hermans-Borgmeyer, Dietmar Kuhl, Michaela Schweizer, Ora Ohana, Jürgen R. Schwarz, Erika L.F. Holzbaur, Matthias Kneussel
Publikováno v:
Cell Reports, Vol 15, Iss 5, Pp 968-977 (2016)
The kinesin KIF21B is implicated in several human neurological disorders, including delayed cognitive development, yet it remains unclear how KIF21B dysfunction may contribute to pathology. One limitation is that relatively little is known about KIF2
Externí odkaz:
https://doaj.org/article/fe8a1afb790842fab33b17605daed690
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e74751 (2013)
Rem2 is a member of the RGK family of small Ras-like GTPases whose expression and function is regulated by neuronal activity in the brain. A number of questions still remain as to the endogenous functions of Rem2 in neurons. RNAi-mediated Rem2 knockd
Externí odkaz:
https://doaj.org/article/ab48b1a1d51740a19a426a419c115afd
Publikováno v:
Nature Reviews Neuroscience. 18:585-597
Neurons are akin to modern cities in that both are dependent on robust transport mechanisms. Like the best mass transit systems, trafficking in neurons must be tailored to respond to local requirements. Neurons depend on both high-speed, long-distanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ac382eef79acf9d15a27548e8693ba
https://doi.org/10.1038/nrn.2017.100
https://doi.org/10.1038/nrn.2017.100
Autor:
Francesca Xompero, Dietmar Kuhl, Corinna Lappe-Siefke, Jürgen R. Schwarz, Kira V. Gromova, Michaela Schweizer, Amy E. Ghiretti, Mary Muhia, Erika L.F. Holzbaur, Matthias Kneussel, Dorthe Labonté, Ora Ohana, Irm Hermans-Borgmeyer, Edda Thies
Publikováno v:
Cell Reports, Vol 15, Iss 5, Pp 968-977 (2016)
The kinesin KIF21B is implicated in several human neurological disorders including delayed cognitive development, yet it remains unclear how KIF21B dysfunction may contribute to pathology. One limitation is that relatively little is known about KIF21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df154f195af7d6ed710019b470a93705
https://doi.org/10.1016/j.celrep.2016.03.086
https://doi.org/10.1016/j.celrep.2016.03.086
Publikováno v:
Molecular Biology of the Cell
Optogenetic recruitment of dynein and kinesin motors to peroxisomes within hippocampal neurons demonstrates that dynein can more efficiently navigate the bipolar dendritic cytoskeleton. Dynein-driven transport is enhanced by dynamic microtubules in b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a364f51ea06927fe361daf435b309640
https://pubmed.ncbi.nlm.nih.gov/28720664
https://pubmed.ncbi.nlm.nih.gov/28720664
Autor:
Anne E. West, Anna R. Moore, Suzanne Paradis, Rebecca G. Brenner, Amy E. Ghiretti, Nelson C. Lau, Stephen D. Van Hooser, Liang-Fu Chen
Publikováno v:
The Journal of Neuroscience. 34:392-407
A key feature of the CNS is structural plasticity, the ability of neurons to alter their morphology and connectivity in response to sensory experience and other changes in the environment. How this structural plasticity is achieved at the molecular l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbcac671d117dc5d0b4c2cda38c3dd0e
https://doi.org/10.1523/jneurosci.1328-13.2014
https://doi.org/10.1523/jneurosci.1328-13.2014
Autor:
Matthias Kneussel, Amy E. Ghiretti, Tianming Lin, Edda Thies, Erika L.F. Holzbaur, Mariko Tokito, E. Michael Ostap
The dendritic arbor is subject to continual activity-dependent remodeling, requiring a balance between directed cargo trafficking and dynamic restructuring of the underlying microtubule tracks. How cytoskeletal components are able to dynamically regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f43b265f9555d9bea75e49f672f056db
https://europepmc.org/articles/PMC5283298/
https://europepmc.org/articles/PMC5283298/
Diverse cellular processes are driven by motor proteins that are recruited to and generate force on lipid membranes. Surprisingly little is known about how membranes control the force from motors and how this may impact specific cellular functions. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d68af7387c22fa80bedcdf9bfbe820e
https://europepmc.org/articles/PMC4851571/
https://europepmc.org/articles/PMC4851571/
Autor:
Suzanne Paradis, Amy E. Ghiretti
Publikováno v:
Trends in neurosciences. 37(7)
The nervous system has the amazing capacity to transform sensory experience from the environment into changes in neuronal activity that, in turn, cause long-lasting alterations in neuronal morphology. Recent findings illustrate a somewhat surprising
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c274b7f87b9945ef3be67610d628197
https://pubmed.ncbi.nlm.nih.gov/24910262
https://pubmed.ncbi.nlm.nih.gov/24910262
Autor:
Suzanne Paradis, Amy E. Ghiretti
Rem2 is a member of the Rad/Rem/Rem2/Gem/Kir subfamily of small Ras-like GTPases that was identified as an important mediator of synapse development. We performed a comprehensive, loss- of-function analysis of Rem2 function in cultured hippocampal ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7744d15bb175a6cbe22402803871cfff
https://europepmc.org/articles/PMC3170433/
https://europepmc.org/articles/PMC3170433/