Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Amy E L Stone"'
Autor:
Amy E L Stone, Angela Mitchell, Jessica Brownell, Daniel J Miklin, Lucy Golden-Mason, Stephen J Polyak, Michael J Gale, Hugo R Rosen
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e95627 (2014)
Plasmacytoid Dendritic Cells (pDCs) represent a key immune cell population in the defense against viruses. pDCs detect viral pathogen associated molecular patterns (PAMPs) through pattern recognition receptors (PRR). PRR/PAMP interactions trigger sig
Externí odkaz:
https://doaj.org/article/60497fd4ff8e4c45bce47e4059ad1892
Autor:
Amy E L Stone, Silvia Giugliano, Gretja Schnell, Linling Cheng, Katelyn F Leahy, Lucy Golden-Mason, Michael Gale, Hugo R Rosen
Publikováno v:
PLoS Pathogens, Vol 9, Iss 4, p e1003316 (2013)
Plasmacytoid Dendritic Cells (pDCs) represent a key immune cell in the defense against viruses. Through pattern recognition receptors (PRRs), these cells detect viral pathogen associated molecular patterns (PAMPs) and initiate an Interferon (IFN) res
Externí odkaz:
https://doaj.org/article/6e8dfcba09db47d78fce26e743a5f205
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
RIG-I- like receptors (RLRs) play an important role in immune defense against West Nile virus (WNV). Here, using a systems biology approach, the authors show that macrophage polarization to a proinflammatory M1 phenotype via RIG-I and MDA5 signaling
Externí odkaz:
https://doaj.org/article/a68c36a70b30446d8eee27564a6f6e14
Autor:
Shelby Feliciano, Megan DeArmond, Ellyn Hirabayashi, Karen M Duus, Terry A Else, Amy E L Stone
Publikováno v:
JBI Evidence Synthesis. 19:1148-1156
OBJECTIVE: The objective of this diagnostic accuracy review is to evaluate the effectiveness of rapid antigen tests versus viral genetic PCR-based tests on COVID-19 diagnostic accuracy in adults 18 years and over. INTRODUCTION: Due to the rapidly cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ffe1ac1013f79d4f83049174d4d2398
https://doi.org/10.11124/jbies-20-00561
https://doi.org/10.11124/jbies-20-00561
Autor:
Angela M. Mitchell, Amy E. L. Stone, Linling Cheng, Kimberly Ballinger, Michael G. Edwards, Mark Stoddard, Hui Li, Lucy Golden-Mason, George M. Shaw, Salman Khetani, Hugo R. Rosen
Publikováno v:
mBio, Vol 6, Iss 2 (2015)
ABSTRACT Hepatitis C virus (HCV) infection leads to persistence in the majority of cases despite triggering complex innate immune responses within the liver. Although hepatocytes are the preferred site for HCV replication, nonparenchymal cells (NPCs)
Externí odkaz:
https://doaj.org/article/bb2504d3a0534ff6a5d2521177419f69
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
RIG-I-Like Receptors (RLRs) RIG-I, MDA5, and LGP2, are vital pathogen recognition receptors in the defense against RNA viruses. West Nile Virus (WNV) infections continue to grow in the US. Here, we use a systems biology approach to define the contrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d14b6863f26eaff64623361a6e4770
http://link.springer.com/article/10.1038/s41467-019-11250-5
http://link.springer.com/article/10.1038/s41467-019-11250-5
Autor:
Eric J. Allenspach, Joshua J. Woodward, Nandan S. Gokhale, Jennifer L. Hyde, Karen Cerosaletti, Joseph Perez, Snehal Ozarkar, Jonathan M. Clingan, Saumendra N. Sarkar, Michael Gale, Justin A Roby, Shivam A. Zaver, Ram Savan, Alison M. Kell, Erola Pairo-Castineira, Adriana Forero, Eileen T. McAnarney, J Kenneth Baillie, Frank Soveg, Chiraag Balu, Jane H. Buckner, Uma Malhotra, Vineet D. Menachery, Cate Speake, Tien-Ying Hsiang, Daniel B. Stetson, Katharina Esser-Nobis, Johannes Schwerk, Amy E. L. Stone, Julian R. Smith
SUMMARYMany host RNA sensors are positioned in the cytosol to detect viral RNA during infection. However, most positive-strand RNA viruses replicate within a modified organelle co-opted from intracellular membranes of the endomembrane system, which s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b59d9d71a19dc95c6e0fb997ea77217
https://doi.org/10.1101/2021.04.21.440697
https://doi.org/10.1101/2021.04.21.440697
Autor:
Socheath Khim, Denny Liggitt, Michael Gale, Yan Ge, Patrick Concannon, John S. Errett, Christian Hundhausen, Tanvi Arkatkar, David J. Rawlings, Xuezhi Dai, Kathleen Pestal, Courtnee Clough, Jane H. Buckner, Mohamed Oukka, Richard G. James, Amy E. L. Stone, Jacquelyn A. Gorman, Karen Cerosaletti, Eric J. Allenspach, Daniel B. Stetson
Publikováno v:
Nature immunology
The single-nucleotide polymorphism rs1990760 in the gene encoding the cytosolic viral sensor IFIH1 results in an amino-acid change (A946T; IFIH1T946) that is associated with multiple autoimmune diseases. The effect of this polymorphism on both viral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04fb8d4000fa8937f69b7071f063b4da
http://europepmc.org/articles/PMC5697900
http://europepmc.org/articles/PMC5697900
Autor:
Hugo R. Rosen, Matthew A. Burchill, Amy E. L. Stone, Justin A Roby, Michael G. Edwards, Michael Kriss, Megan Wind-Rotolo, Rachael J Dran, Michael Gale, Nanette Crochet
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 10, p e0186213 (2017)
PLoS ONE, Vol 12, Iss 10, p e0186213 (2017)
Chronic hepatitis C virus (HCV) infection results in sustained immune activation in both the periphery and hepatic tissue. HCV infection induces innate immune signaling that is responsible for recognition of dsRNA, leading to activation of transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9210733a688e2e68c4bbd97c4384c6
https://pubmed.ncbi.nlm.nih.gov/29040318
https://pubmed.ncbi.nlm.nih.gov/29040318
Autor:
Amy E. L. Stone, Michael Gale
Publikováno v:
Hepatology (Baltimore, Md.). 65(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd80d89ed8db1fd6d774c21d6b3ba90
https://pubmed.ncbi.nlm.nih.gov/28195391
https://pubmed.ncbi.nlm.nih.gov/28195391