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Mechanism of Prion Loss after Hsp104 Inactivation in Yeast

Autor: Renee D. Wegrzyn, Yury O. Chernoff, Kavita P. Bapat, Gary P. Newnam, Amy D. Zink

Publikováno v: Molecular and Cellular Biology. 21:4656-4669

In vivo propagation of [PSI(+)], an aggregation-prone prion isoform of the yeast release factor Sup35 (eRF3), has previously been shown to require intermediate levels of the chaperone protein Hsp104. Here we perform a detailed study on the mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4750b9752a4361e3c46e64859da2034e
https://doi.org/10.1128/mcb.21.14.4656-4669.2001

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Evidence for a Protein Mutator in Yeast: Role of the Hsp70-Related Chaperone Ssb in Formation, Stability, and Toxicity of the [PSI] Prion

Autor: Gary P. Newnam, Kim D. Allen, Jaijit Kumar, Amy D. Zink, Yury O. Chernoff

Publikováno v: Molecular and Cellular Biology. 19:8103-8112

Propagation of the yeast protein-based non-Mendelian element [PSI], a prion-like form of the release factor Sup35, was shown to be regulated by the interplay between chaperone proteins Hsp104 and Hsp70. While overproduction of Hsp104 protein cures ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4da583f11d1e2938f98bef8f47d8b6
https://doi.org/10.1128/mcb.19.12.8103

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