Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Amy D. Hanna"'
Autor:
Chang Seok Lee, Sung Yun Jung, Rachel Sue Zhen Yee, Nadia H. Agha, Jin Hong, Ting Chang, Lyle W. Babcock, Jorie D. Fleischman, Benjamin Clayton, Amy D. Hanna, Christopher S. Ward, Denise Lanza, Ayrea E. Hurley, Pumin Zhang, Xander H. T. Wehrens, William R. Lagor, George G. Rodney, Susan L. Hamilton
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-19 (2023)
Abstract Here we show that striated muscle preferentially expressed protein kinase α (Spegα) maintains cardiac function in hearts with Spegβ deficiency. Speg is required for stability of excitation-contraction coupling (ECC) complexes and interact
Externí odkaz:
https://doaj.org/article/7a8ed53a9dd64509bc4efd890aaae296
Publikováno v:
Skeletal Muscle, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Background Manual analysis of cross-sectional area, fiber-type distribution, and total and centralized nuclei in skeletal muscle cross sections is tedious and time consuming, necessitating an accurate, automated method of analysis. While sev
Externí odkaz:
https://doaj.org/article/9d30bc95daf64b22bd571af210ebd2dd
Autor:
Hui J. Wang, Chang Seok Lee, Rachel Sue Zhen Yee, Linda Groom, Inbar Friedman, Lyle Babcock, Dimitra K. Georgiou, Jin Hong, Amy D. Hanna, Joseph Recio, Jong Min Choi, Ting Chang, Nadia H. Agha, Jonathan Romero, Poonam Sarkar, Nicol Voermans, M. Waleed Gaber, Sung Yun Jung, Matthew L. Baker, Robia G. Pautler, Robert T. Dirksen, Sheila Riazi, Susan L. Hamilton
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Individuals with malignant hyperthermia susceptibility (MHS) suffer from lifethreatening responses to heat. Here the authors demonstrate that adaptive thermogenesis from brown adipose tissue contributes to this heat sensitivity in a preclinical mouse
Externí odkaz:
https://doaj.org/article/1dca01fbb1744c91925d570cd3ada4fa
Autor:
Chang Seok Lee, Amy D. Hanna, Hui Wang, Adan Dagnino-Acosta, Aditya D. Joshi, Mark Knoblauch, Yan Xia, Dimitra K. Georgiou, Jianjun Xu, Cheng Long, Hisayuki Amano, Corey Reynolds, Keke Dong, John C. Martin, William R. Lagor, George G. Rodney, Ergun Sahin, Caroline Sewry, Susan L. Hamilton
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Mutations in the RyR1 channel cause core myopathies. Here the authors show that ER stress and the unfolded protein response underlie the pathology caused by a common RyR1 channel mutation, and show that treatment with a chemical chaperone restores mu
Externí odkaz:
https://doaj.org/article/8a7faf752203416684267602ebe0758b
Publikováno v:
FASEB J
Mice with a mutation (D244G, DG) in calsequestrin 1 (CASQ1), analogous to a human mutation in CASQ1 associated with a delayed onset human myopathy (vacuolar aggregate myopathy), display a progressive myopathy characterized by decreased activity, decr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba44a3d5e2443c5411a90de272c22b9
https://doi.org/10.1096/fj.202001653rr
https://doi.org/10.1096/fj.202001653rr
Autor:
Natalia Kraeva, Anna Roszkowska, Ezel Boyacı, Amy D. Hanna, Barbara Bojko, Janusz Pawliszyn, Marcin Wąsowicz, Annabel Koivu, Sheila Riazi, Tijana Vasiljevic, Carlos A. Ibarra Moreno, Susan L. Hamilton
Publikováno v:
Can J Anaesth
Malignant hyperthermia (MH) is a potentially fatal hypermetabolic condition triggered by certain anesthetics and caused by defective calcium homeostasis in skeletal muscle cells. Recent evidence has revealed impairment of various biochemical pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bffe7e0318b862fbd5fd9b41576b3af
https://pubmed.ncbi.nlm.nih.gov/33532996
https://pubmed.ncbi.nlm.nih.gov/33532996
Autor:
Hermia Willemse, Chris Thekkedam, Nicole A. Beard, Alexander Lam, Amy D. Hanna, Angela F. Dulhunty
Publikováno v:
Molecular Pharmacology. 92:576-587
The chemotherapeutic anthracycline metabolite doxorubicinol (doxOL) has been shown to interact with and disrupt the function of the cardiac ryanodine receptor Ca2+ release channel (RyR2) in the sarcoplasmic reticulum (SR) membrane and the SR Ca2+ bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36c1d544417248fb2618645136a7912b
https://doi.org/10.1124/mol.117.108183
https://doi.org/10.1124/mol.117.108183
Autor:
Corey L. Reynolds, Amy D. Hanna, Hui J. Wang, Yan Xia, George G. Rodney, Cheng Long, William R. Lagor, Keke Dong, Hisayuki Amano, Ergun Sahin, John C. Martin, Dimitra K. Georgiou, Mark Knoblauch, Aditya D. Joshi, Adan Dagnino-Acosta, Chang Seok Lee, Susan L. Hamilton, Jianjun Xu, Caroline Sewry
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature Communications
Mutations in the RYR1 gene cause severe myopathies. Mice with an I4895T mutation in the type 1 ryanodine receptor/Ca2+ release channel (RyR1) display muscle weakness and atrophy, but the underlying mechanisms are unclear. Here we show that the I4895T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e84c20b95dcf268f683054bd66cc5d
https://doaj.org/article/8a7faf752203416684267602ebe0758b
https://doaj.org/article/8a7faf752203416684267602ebe0758b
Autor:
Adan Dagnino-Acosta, Thomas A. Cooper, Mark Knoblauch, Simona Pedrotti, Ravi K. Singh, Jimena Giudice, John Hicks, Qianxing Mo, Susan L. Hamilton, Amy D. Hanna
Publikováno v:
Human Molecular Genetics. 24:2360-2374
The Rbfox family of RNA-binding proteins is highly conserved with established roles in alternative splicing (AS) regulation. High-throughput studies aimed at understanding transcriptome remodeling have revealed skeletal muscle as displaying one of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c74d131bf7c7bfa568c53c40bd8f07
https://doi.org/10.1093/hmg/ddv003
https://doi.org/10.1093/hmg/ddv003
Autor:
Amy D, Hanna, Alexander, Lam, Chris, Thekkedam, Hermia, Willemse, Angela F, Dulhunty, Nicole A, Beard
Publikováno v:
Molecular pharmacology. 92(5)
The chemotherapeutic anthracycline metabolite doxorubicinol (doxOL) has been shown to interact with and disrupt the function of the cardiac ryanodine receptor Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3af6a595523e3bb797f727ee081faf12
https://pubmed.ncbi.nlm.nih.gov/28916620
https://pubmed.ncbi.nlm.nih.gov/28916620