Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Amy D. Gelinas"'
Autor:
Amy D. Gelinas, Tiong Kit Tan, Sai Liu, Javier G. Jaramillo, James Chadwick, Adam C. Harding, Chi Zhang, Brian E. Ream, Chelsea N. Chase, Matthew R. Otis, Thomas Lee, Daniel J. Schneider, William S. James, Nebojsa Janjic
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 370-382 (2023)
Since its discovery, COVID-19 has rapidly spread across the globe and has had a massive toll on human health, with infection mortality rates as high as 10%, and a crippling impact on the world economy. Despite numerous advances, there remains an urge
Externí odkaz:
https://doaj.org/article/94161dc783b24b7ab274f1e5261a3624
Autor:
David Stacey, Lingyan Chen, Paulina J. Stanczyk, Joanna M. M. Howson, Amy M. Mason, Stephen Burgess, Stephen MacDonald, Jonathan Langdown, Harriett McKinney, Kate Downes, Neda Farahi, James E. Peters, Saonli Basu, James S. Pankow, Weihong Tang, Nathan Pankratz, Maria Sabater-Lleal, Paul S. de Vries, Nicholas L. Smith, CHARGE Hemostasis Working Group, Amy D. Gelinas, Daniel J. Schneider, Nebojsa Janjic, Nilesh J. Samani, Shu Ye, Charlotte Summers, Edwin R. Chilvers, John Danesh, Dirk S. Paul
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Many individual genetic risk loci associate with multiple diseases, but the molecular basis of these loci often remains unclear. Here, the authors provide a framework to reveal the genetic cross-disease associations at the PROCR vascular disease locu
Externí odkaz:
https://doaj.org/article/06e0764427f642ea9f1647a016e4fe9d
Autor:
David Stacey, Lingyan Chen, Paulina J. Stanczyk, Joanna M. M. Howson, Amy M. Mason, Stephen Burgess, Stephen MacDonald, Jonathan Langdown, Harriett McKinney, Kate Downes, Neda Farahi, James E. Peters, Saonli Basu, James S. Pankow, Weihong Tang, Nathan Pankratz, Maria Sabater-Lleal, Paul S. de Vries, Nicholas L. Smith, CHARGE Hemostasis Working Group, Amy D. Gelinas, Daniel J. Schneider, Nebojsa Janjic, Nilesh J. Samani, Shu Ye, Charlotte Summers, Edwin R. Chilvers, John Danesh, Dirk S. Paul
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/1a0ca0f841d5435e8760059b3c401a54
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The cytokine interleukin 1α (IL-1α) plays an important role in inflammatory processes. Here the authors use SELEX to generate a modified DNA aptamer which specifically binds IL-1α, present the structure of the IL-1α/aptamer complex and show that
Externí odkaz:
https://doaj.org/article/e2cdd527a9be48b8adaaa6d5896332bd
Autor:
Nebojsa Janjic, Zuben E. Sauna, Katarzyna I. Jankowska, William C. Chang, Amy D. Gelinas, Wojciech Jankowski, H.A. Daniel Lagassé, Joseph R. McGill
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Reliable and reproducible monitoring of the conformational state of therapeutic protein products remains an unmet technological need. This need is amplified by the increasing number of biosimilars entering the drug development pipeline as many brande
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381b5800079fec40335ce3f73a5a5e5d
http://link.springer.com/article/10.1038/s41598-020-75713-2
http://link.springer.com/article/10.1038/s41598-020-75713-2
Autor:
Larry Gold, Nebojsa Janjic, Edward N. Brody, Guillot Jessica, Steven K. Wolk, David P. Astling, Wesley S. Mayfield, Amy D. Gelinas
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
The modern version of the RNA World Hypothesis begins with activated ribonucleotides condensing (nonenzymatically) to make RNA molecules, some of which possess (perhaps slight) catalytic activity. We propose that noncanonical ribonucleotides, which w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f021658d0f6db386f0081e09dbe83f1
https://doi.org/10.1073/pnas.1809041117
https://doi.org/10.1073/pnas.1809041117
Autor:
Daniel J. Schneider, Sean A. Lynch, Amy D. Gelinas, Rachel M. Ostroff, John C. Rohloff, Preston Williams, Nebojsa Janjic, Daniel W. Drolet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54bc62a17bb60234674de8af2dfda6aa
https://doi.org/10.1016/b978-0-12-821595-1.00007-5
https://doi.org/10.1016/b978-0-12-821595-1.00007-5
Autor:
Mohamad-Gabriel Alameh, Marice Alcantara, Jessica Alluin, Paola Amero, Virginia Arechavala-Gomeza, George A. Calin, David R. Corey, Hagen Cramer, Niels Dammes, Daniel W. Drolet, James Frederiksen, Amy D. Gelinas, Nagy A. Habib, Inbal Hazan-Halevy, Kevin Holm, Nebojsa Janjic, Krystal C. Johnson, Samantha T. Johnson, Edo Kon, Marcin Kortylewski, Dalit Landesman-Milo, Marc M. Lemaitre, Christopher Lincoln, Gabriel Lopez-Berestein, Sean A. Lynch, Selin Oncul, Rachel M. Ostroff, Dan Peer, Cristian Rodriguez-Aguayo, John C. Rohloff, Daniel Rossi, John J. Rossi, Thomas M. Rupp, Daniel J. Schneider, Patricia Soblechero-Martín, Min-Sun Song, Anil K. Sood, Yu-Lin Su, Bruce A. Sullenger, Jon Voutila, Drew Weissman, Preston Williams, Chunsong Yu, Haixiang Yu, Zhuoran Zhang, Jiehua Zhou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::716f968d155a5029d4ea30ec9d4c3e57
https://doi.org/10.1016/b978-0-12-821595-1.09994-2
https://doi.org/10.1016/b978-0-12-821595-1.09994-2
Autor:
Darón I. Freedberg, David D. Holcomb, Ryan C. Hunt, Kazuyo Takeda, Amy D. Gelinas, Dougald M. Monroe, Puja Nanavaty, Robert Peters, John C. Athey, Zuben E. Sauna, Vijaya L. Simhadri, Aikaterini Alexaki, Nebojsa Janjic, Nobuko Hamasaki-Katagiri, Joseph R. McGill, Michael DiCuccio, Upendra K. Katneni, Jacob Kames, Haim Bar, Anton A. Komar, Gaya K. Hettiarachchi, Brian Lin, Chava Kimchi-Sarfaty
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Synonymous codons occur with different frequencies in different organisms, a phenomenon termed codon usage bias. Codon optimization, a common term for a variety of approaches used widely by the biopharmaceutical industry, involves synonymous substitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a48c7336e6ffd6d2d4c2275e3fe921
http://link.springer.com/article/10.1038/s41598-019-51984-2
http://link.springer.com/article/10.1038/s41598-019-51984-2
Autor:
John C Rohloff, Amy D Gelinas, Thale C Jarvis, Urs A Ochsner, Daniel J Schneider, Larry Gold, Nebojsa Janjic
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 3, Iss C (2014)
Limited chemical diversity of nucleic acid libraries has long been suspected to be a major constraining factor in the overall success of SELEX (Systematic Evolution of Ligands by EXponential enrichment). Despite this constraint, SELEX has enjoyed con
Externí odkaz:
https://doaj.org/article/746f6750c39f4bba99406639d7eff0f5