Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Amy D. Bradshaw"'
Autor:
Stephen C. Zambrzycki, Samaneh Saberi, Rachel Biggs, Najmeh Eskandari, Davide Delisi, Harrison Taylor, Anand S. Mehta, Richard R. Drake, Saverio Gentile, Amy D. Bradshaw, Michael Ostrowski, Peggi M. Angel
Publikováno v:
Matrix Biology Plus, Vol 24, Iss , Pp 100161- (2024)
While numerous approaches have been reported towards understanding single cell regulation, there is limited understanding of single cell production of extracellular matrix phenotypes. Collagens are major proteins of the extracellular microenvironment
Externí odkaz:
https://doaj.org/article/8655775cea6947d09f3fda8438964bbe
Decellularized heart extracellular matrix alleviates activation of hiPSC-derived cardiac fibroblasts
Autor:
Charles M. Kerr, Sophia E. Silver, Yi Sun Choi, Martha E. Floy, Amy D. Bradshaw, Seung-Woo Cho, Sean P. Palecek, Ying Mei
Publikováno v:
Bioactive Materials, Vol 31, Iss , Pp 463-474 (2024)
Human induced pluripotent stem cell derived cardiac fibroblasts (hiPSC-CFs) play a critical role in modeling human cardiovascular diseases in vitro. However, current culture substrates used for hiPSC-CF differentiation and expansion, such as Matrigel
Externí odkaz:
https://doaj.org/article/085242f56f0e407293727c5ae5c5b1f0
Autor:
Rachel Biggs, Daniel N. Silverman, Yuhua Zhang, Catalin F. Baicu, Michael R. Zile, Amy D. Bradshaw
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 127-127 (2024)
OBJECTIVES/GOALS: Myocardial interstitial fibrosis leads to high hemodynamic load resulting in heart failure (HFrEF). Previous studies show that treatment with a left ventricular assist device (LVAD) does not reduce fibrosis. We hypothesize that huma
Externí odkaz:
https://doaj.org/article/61df85a3a28d44e086783c9964131238
Publikováno v:
Biomolecules, Vol 12, Iss 1, p 11 (2021)
During homeostasis, immune cells perform daily housekeeping functions to maintain heart health by acting as sentinels for tissue damage and foreign particles. Resident immune cells compose 5% of the cellular population in healthy human ventricular ti
Externí odkaz:
https://doaj.org/article/24d66616eca64f60b8efa14d3533c675
Autor:
Michael R. Zile, Amy D. Bradshaw
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 323(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::964a949816d8603fb772778f1df0b877
https://pubmed.ncbi.nlm.nih.gov/35687503
https://pubmed.ncbi.nlm.nih.gov/35687503
Ensemble machine learning model identifies patients with HFpEF from matrix-related plasma biomarkers
Autor:
Michael Ward, Amirreza Yeganegi, Catalin F. Baicu, Amy D. Bradshaw, Francis G. Spinale, Michael R. Zile, William J. Richardson
Publikováno v:
Am J Physiol Heart Circ Physiol
Arterial hypertension can lead to structural changes within the heart including left ventricular hypertrophy (LVH) and eventually heart failure with preserved ejection fraction (HFpEF). The initial diagnosis of HFpEF is costly and generally based on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f29f7c60c5a16f6aac9008519d41f5
https://doi.org/10.1152/ajpheart.00497.2021
https://doi.org/10.1152/ajpheart.00497.2021
Autor:
Amy D. Bradshaw
Publikováno v:
Encyclopedia of Cell Biology ISBN: 9780128216248
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ec47cf8ffe2efd2e477439cf61fc4a3
https://doi.org/10.1016/b978-0-12-821618-7.00088-2
https://doi.org/10.1016/b978-0-12-821618-7.00088-2
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 11 (2022)
Biomolecules
Biomolecules
During homeostasis, immune cells perform daily housekeeping functions to maintain heart health by acting as sentinels for tissue damage and foreign particles. Resident immune cells compose 5% of the cellular population in healthy human ventricular ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf58cf0f94863c244c6b7d0f2ad06c5
https://www.mdpi.com/2218-273X/12/1/11
https://www.mdpi.com/2218-273X/12/1/11
Autor:
Lily S. Neff, Yuhua Zhang, An O. Van Laer, Catalin F. Baicu, Mark Karavan, Michael R. Zile, Amy D. Bradshaw
Publikováno v:
Am J Physiol Heart Circ Physiol
Left ventricular pressure overload (LVPO) can develop from antecedent diseases such as aortic valve stenosis and systemic hypertension and is characterized by accumulation of myocardial extracellular matrix (ECM). Evidence from patient and animal mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe51820469397e024f7f24840912b4e
https://europepmc.org/articles/PMC9236876/
https://europepmc.org/articles/PMC9236876/
Autor:
An O. Van Laer, Catalin F. Baicu, Amy D Bradshaw, Amanda C. LaRue, Hannah J. Riley, Ryan R. Kelly, Lindsay T. McDonald, Shaoni Dasgupta, Lily S. Neff, Michael R. Zile
Publikováno v:
Am J Physiol Heart Circ Physiol
In human heart failure and in murine hearts with left-ventricular pressure overload (LVPO), increases in fibrosis are associated with increases in myocardial stiffness. Secreted protein acidic and rich in cysteine (SPARC) is shown to be necessary for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3ac8f8bdaa6fcd67d34e968a887746
https://doi.org/10.1152/ajpheart.00552.2020
https://doi.org/10.1152/ajpheart.00552.2020