Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Amy D, Fung"'
Autor:
Willard Lew, Ute Hoch, Jeffrey A. Silverman, Stacey A. Heumann, Sheryl N. Ivy, Stuart Lam, Minna Bui, Hanan Emily, Thomas O'Brien, W. Michael Flanagan, Robert A. Elling, Bradley T. Tangonan, Hans E. Purkey, Heman Lee, Min Zhong, Subramanian Baskaran, Kristin M. Zimmerman, Pietro Taverna, Robert S. McDowell, Amy D. Fung, Wang Shen, Shannon O. Harris, Michael J. Romanowski, Wenjin Yang, Jeffrey W. Jacobs, Joshua C. Yoburn, Darin Allen, Chul Yu, Johan D. Oslob
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5158-5161
This Letter describes the discovery and key structure-activity relationship (SAR) of a series of 2-aminobenzimidazoles as potent Aurora kinase inhibitors. 2-Aminobenzimidazole serves as a bioisostere of the biaryl urea residue of SNS-314 (1c), which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3f97920374b8e6e5f11cd9c42ab0bc
https://doi.org/10.1016/j.bmcl.2009.07.016
https://doi.org/10.1016/j.bmcl.2009.07.016
Autor:
Graham K. Farrington, Jessica E. Friedman, Joshua C. Yoburn, Alexey Lugovskoy, William Michael Flanagan, Stephan K. Miller, Brian C. Cunningham, Amy D. Fung, Adrian Whitty, Molly M. He, Jun Wang, Annemarie Stroustrup Smith, Mark T. Cancilla, John Eldredge, Leslie A. Cruz, Johan D. Oslob, Teresa G. Cachero, Andrew C. Braisted, Eric S. Day, Ingrid C. Choong
Publikováno v:
Science. 310:1022-1025
We have identified a small-molecule inhibitor of tumor necrosis factor α (TNF-α) that promotes subunit disassembly of this trimeric cytokine family member. The compound inhibits TNF-α activity in biochemical and cell-based assays with median inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a6ce3328b91c59024e2eaf119ff3ef0
https://doi.org/10.1126/science.1116304
https://doi.org/10.1126/science.1116304
Autor:
Subramanian Baskaran, Jeffrey A. Silverman, Jack Maung, Stacey A. Heumann, Hashash Ahmad, Johan D. Oslob, Robert S. McDowell, Willard Lew, Minna Bui, Chul Yu, Michael J. Romanowski, Tarra Fuchs-Knotts, Jeffrey W. Jacobs, Jonathan Hau, Wenjin Yang, Darin Allen, Min Zhong, Amy D. Fung, Sheryl N. Ivy, Erlie Marie Delarosa, Sean Ritchie
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(5)
Compound 1 (SNS-314) is a potent and selective Aurora kinase inhibitor that is currently in clinical trials in patients with advanced solid tumors. This communication describes the synthesis of prodrug derivatives of 1 with improved aqueous solubilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bec73e8f2a8e0074d6d3e16c6a29438
https://pubmed.ncbi.nlm.nih.gov/19186057
https://pubmed.ncbi.nlm.nih.gov/19186057
Autor:
Shannon O. Harris, Stacey A. Heumann, Jeffrey W. Jacobs, William Michael Flanagan, Subramanian Baskaran, Kristin M. Zimmerman, Darin Allen, Minna Bui, Michael J. Romanowski, Bradley T. Tangonan, Johan D. Oslob, Robert S. McDowell, Wang Shen, Chris E Lawrence, Juli N. Teague, Willard Lew, Michelle M. Sopko, Michelle A. Nannini, Jeffrey A. Silverman, Joshua C. Yoburn, Chul Yu, Min Zhong, Hanan Emily, Ute Hoch, Amy D. Fung, Joni Lam, Robert A. Elling, Thomas O'Brien
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(17)
This communication describes the discovery of a novel series of Aurora kinase inhibitors. Key SAR and critical binding elements are discussed. Some of the more advanced analogues potently inhibit cellular proliferation and induce phenotypes consisten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6628e44d37788613c268d76ba8583b8
https://pubmed.ncbi.nlm.nih.gov/18678489
https://pubmed.ncbi.nlm.nih.gov/18678489
Autor:
Meggin Taylor, Robert Lowell Simmons, Amy D. Fung, Daniel A. Erlanson, Mark T. Cancilla, Nina Viswanathan, Molly M. He, Kathy Cao
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(14)
We demonstrate a fragment-based lead discovery method that combines site-directed ligand discovery with dynamic combinatorial chemistry. Our technique targets dynamic combinatorial screening to a specified region of a protein by using reversible disu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33befa3e15b5fc13cae9098dcb5cbc75
https://pubmed.ncbi.nlm.nih.gov/18579375
https://pubmed.ncbi.nlm.nih.gov/18579375
Autor:
Molly M, He, Annemarie Stroustrup, Smith, Johan D, Oslob, William M, Flanagan, Andrew C, Braisted, Adrian, Whitty, Mark T, Cancilla, Jun, Wang, Alexey A, Lugovskoy, Josh C, Yoburn, Amy D, Fung, Graham, Farrington, John K, Eldredge, Eric S, Day, Leslie A, Cruz, Teresa G, Cachero, Stephan K, Miller, Jessica E, Friedman, Ingrid C, Choong, Brian C, Cunningham
Publikováno v:
Science (New York, N.Y.). 310(5750)
We have identified a small-molecule inhibitor of tumor necrosis factor alpha (TNF-alpha) that promotes subunit disassembly of this trimeric cytokine family member. The compound inhibits TNF-alpha activity in biochemical and cell-based assays with med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::896527c8737cc4d728d7f4577b06518d
https://pubmed.ncbi.nlm.nih.gov/16284179
https://pubmed.ncbi.nlm.nih.gov/16284179
Publikováno v:
Molecular and cellular biology. 22(13)
The fission yeast Dbf4 homologue Dfp1 has a well-characterized role in regulating the initiation of DNA replication. Sequence analysis of Dfp1 homologues reveals three highly conserved regions, referred to as motifs N, M, and C. To determine the role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9efa8b6186f64e4a4acefcc61bca6568
https://pubmed.ncbi.nlm.nih.gov/12052858
https://pubmed.ncbi.nlm.nih.gov/12052858
Autor:
Jessica E. Friedman, Teresa G. Cachero, Eric S. Day, Lihe Su, Laura Silvian, Kathy Strauch, Gerald W. Shipps, Brian T. Cunningham, Amy D. Fung, Adrian Whitty, Gnanasambandam Kumaravel, Lihong Sun, Zhongli Zheng, Fang Qian
Publikováno v:
ACS Chemical Biology. 6:761-761
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3637a58c508f11f876eec9bf4c54f312
https://doi.org/10.1021/cb200195p
https://doi.org/10.1021/cb200195p