Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Amy Cuthbert"'
Autor:
Dale L. Greiner, Alvin C. Powers, Lisa M. Burzenski, M.M. Herlihy, Philip diIorio, Bruce Gott, Joseph Laning, Oded Foreman, Chaoxing Yang, Leonard D. Shultz, Michael A. Brehm, Jean Leif, Amy Cuthbert, Rita Bortell
Publikováno v:
Diabetes
OBJECTIVE To create an immunodeficient mouse model that spontaneously develops hyperglycemia to serve as a diabetic host for human islets and stem cell–derived β-cells in the absence or presence of a functional human immune system. RESEARCH DESIGN
Autor:
Dale L. Greiner, Oded Foreman, Michael A. Brehm, Bruce Gott, Lisa M. Burzenski, J Laning, David Miller, Amy Cuthbert, Philip diIorio, Aldo A. Rossini, Chaoxing Yang, Leonard D. Shultz, Anoop Kavirayani, M.M. Herlihy
Publikováno v:
Clinical Immunology. 135:84-98
"Humanized" mouse models created by engraftment of immunodeficient mice with human hematolymphoid cells or tissues are an emerging technology with broad appeal across multiple biomedical disciplines. However, investigators wishing to utilize humanize
Autor:
Bonnie L. Lyons, Bruce Gott, Oded Foreman, Aldo A. Rossini, David Miller, William Fodor, J Laning, Dale L. Greiner, Lisa M. Burzenski, Todd Pearson, Marie A. King, Leonard D. Shultz, Amy Cuthbert
Publikováno v:
Clinical and Experimental Immunology. 154:270-284
Immunodeficient hosts engrafted with human lymphohaematopoietic cells hold great promise as a preclinical bridge for understanding human haematopoiesis and immunity. We now describe a new immunodeficient radioresistant non-obese diabetic mice (NOD) s
Autor:
Jean Leif, Aldo A. Rossini, Michael C. Appel, Dale L. Greiner, Scott J. Banuelos, Amy Cuthbert, Nancy E. Phillips, Thomas G. Markees, Leonard D. Shultz, John P. Mordes
Publikováno v:
Transplantation. 78:660-667
Background. Donor-specific transfusion (DST) and a brief course of anti-CD 154 monoclonal antibody (mAb) induces permanent islet and prolonged skin allograft survival in mice. Induction of skin allograft survival requires the presence of CD4 + cells
Autor:
Andrew Jackson, Dale L. Greiner, Leonard D. Shultz, Nicole Ali McNeer, Kavitha Anandalingam, Erica B. Schleifman, W. Mark Saltzman, Christopher J. Cheng, Peter M. Glazer, Priti Kumar, Amy Cuthbert, Michael A. Brehm
Publikováno v:
Gene therapy. 20(6)
In vivo delivery is a major barrier to the use of molecular tools for gene modification. Here we demonstrate site-specific gene editing of human cells in vivo in hematopoietic stem cell-engrafted NOD.Cg-Prkdc(scid)IL2rγ(tm1Wjl) (abbreviated NOD-scid
Autor:
Raymond M. Welsh, Dale L. Greiner, Bhavana Priyadharshini, Thomas B. Thornley, Michael A. Brehm, Amy Cuthbert, Keith A. Daniels
Publikováno v:
Immunology. 138(4)
Blockade of co-stimulatory signals to T cells is extremely effective for the induction of transplantation tolerance in immunologically naive rodents. However, infections and inflammation compromise the efficacy of co-stimulation blockade regimens for
Publikováno v:
The Journal of Immunology. 192:70.4-70.4
Costimulation blockade targeting the CD40-CD154 pathway is an effective approach to induce tolerance to allografts in murine and non-human primate models. However inflammation generated during infection and exposure to pathogen associated molecular p
Autor:
Kristen Biber, Amy Cuthbert, Dale L. Greiner, Lowry A. Phillip, Lisa J. Giassi, Leonard D. Shultz, Joseph Laning
Publikováno v:
Blood. 106:5215-5215
Umbilical cord blood (UCB) is a source of stem cells for hematopoietic transplantation (Laughlin, et al. NEJM2004; 351:2265) but application in adults is limited by marginal stem cell numbers. Combining cord blood units has shown promise in achieving
Autor:
Thomas G Markees, Todd Pearson, Amy Cuthbert, Andrea L Pearson, Leonard D Shultz, Jean Leif, Nancy E Phillips, John P Mordes, Dale L Greiner, Aldo A Rossini
Publikováno v:
Transplantation; Dec2004, Vol. 78 Issue 11, p1601-1608, 8p