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Akademický článek

Efficacy of xanomeline and trospium chloride in schizophrenia: pooled results from three 5-week, randomized, double-blind, placebo-controlled, EMERGENT trials

Autor: Inder Kaul, Sharon Sawchak, Amy Claxton, Colin Sauder, Howard H. Hassman, Rishi Kakar, David P. Walling, Leslie Citrome, Haiyuan Zhu, Andrew C. Miller, Stephen K. Brannan

Publikováno v: Schizophrenia, Vol 10, Iss 1, Pp 1-9 (2024)

Abstract In the 5-week, randomized, double-blind, placebo-controlled EMERGENT-1 (NCT03697252), EMERGENT-2 (NCT04659161), and EMERGENT-3 (NCT04738123) trials, xanomeline and trospium chloride (formerly known as KarXT) significantly improved symptoms o

Externí odkaz: https://doaj.org/article/b60b332911db4c559f92ba32ff23af15

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Akademický článek

Aripiprazole lauroxil 2-month formulation with 1-day initiation in patients hospitalized for an acute exacerbation of schizophrenia: exploratory efficacy and patient-reported outcomes in the randomized controlled ALPINE study

Autor: Henry A. Nasrallah, Peter J. Weiden, David P. Walling, Yangchun Du, Baiyun Yao, Sergey Yagoda, Amy Claxton

Publikováno v: BMC Psychiatry, Vol 21, Iss 1, Pp 1-13 (2021)

Abstract Background A randomized, controlled, phase 3b study (ALPINE) evaluated efficacy and safety of a 2-month formulation of aripiprazole lauroxil (AL) using a 1-day initiation regimen in patients hospitalized for an acute exacerbation of schizoph

Externí odkaz: https://doaj.org/article/eadc67c7e7c04be7af8d394b3a87cbf9

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A Comparison of Volatile Anesthesia and Total Intravenous Anesthesia (TIVA) Effects on Outcome From Cardiac Surgery: A Systematic Review and Meta-Analysis

Autor: Thomas Park, R. Peter Alston, Celine Chan Ah Song, Sarah Hutton, Amy Claxton, Thomas Sharkey, Jamie Beverstock, Joseph Fathers, Will Cawley

Publikováno v: Journal of Cardiothoracic and Vascular Anesthesia. 35:1096-1105

Objective The primary objective of this study was to compare one-year mortality in patients undergoing cardiac surgery with volatile anesthesia or total intravenous anesthesia (TIVA). Secondary objectives were to compare in-hospital and 30-day mortal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d685e5d1617d0458b8f2125472fc26
https://doi.org/10.1053/j.jvca.2020.10.036

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Handwriting Kinematics in Patients with Schizophrenia Treated with Long-Acting Injectable Atypical Antipsychotics: Results From the ALPINE Study

Autor: Michael P Caligiuri, Peter J Weiden, Anna Legedza, Sergey Yagoda, Amy Claxton

Publikováno v: Schizophrenia Bulletin Open. 3

Handwriting kinematics (HWKs) were assessed in the randomized controlled ALPINE study of 2 long-acting injectable antipsychotics started during an acute exacerbation of schizophrenia. This exploratory analysis examined the relationship between baseli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d87d4c8304ca2f223eeda62db6009f03
https://doi.org/10.1093/schizbullopen/sgac018

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Autor: Yangchun Du, Henry A. Nasrallah, Baiyun Yao, Peter J. Weiden, David P. Walling, Amy Claxton, Sergey Yagoda

Publikováno v: BMC Psychiatry
BMC Psychiatry, Vol 21, Iss 1, Pp 1-13 (2021)

Background A randomized, controlled, phase 3b study (ALPINE) evaluated efficacy and safety of a 2-month formulation of aripiprazole lauroxil (AL) using a 1-day initiation regimen in patients hospitalized for an acute exacerbation of schizophrenia. Pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106579879617f20197e57eb26867da0d
http://europepmc.org/articles/PMC8501701

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Social and functional outcomes with two doses of aripiprazole lauroxil vs placebo in patients with schizophrenia: a post-hoc analysis of a 12-week phase 3 efficacy study

Autor: Amy Claxton, Peter J. Weiden, Arielle D. Stanford, Yangchun Du, Christoph U. Correll

Publikováno v: Psychiatry Research. 274:176-181

To assess the effect of the long-acting antipsychotic aripiprazole lauroxil (AL) on social and functional outcomes compared with placebo in patients with acute schizophrenia, a post-hoc analysis was conducted. Patients with acute schizophrenia were e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eca3b7ff28c1ecd4d037c5ae876da88
https://doi.org/10.1016/j.psychres.2019.02.021

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Clinical Management of Patients with Schizophrenia Treated with Long-Acting Injectable Antipsychotics and Telepsychiatry Use During COVID-19 Pandemic

Autor: Leona Bessonova, Elizabeth Keane, Eric Achtyes, Philip D. Harvey, John M. Kane, Stephen R. Saklad, Jeffrey Trotter, Amy Claxton, Tiffany Hatfield, James McGrory, Wahidullah Noori, Amy K. O’Sullivan, Joshua E. Biber, Asia Sikora Kessler, Aaron Yarlas, Dawn I. Velligan

Publikováno v: CNS Spectrums. 27:230-230

BackgroundThe COVID-19 pandemic substantially impacted care of patients with schizophrenia treated with long-acting injectable antipsychotics (LAIs). This study examined how clinics adapted operations to maintain a standard of care for these patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::217fab1bfe95fdeacf079288e0913d8a
https://doi.org/10.1017/s1092852922000256

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Efficacy and Safety of a 2-Month Formulation of Aripiprazole Lauroxil With 1-Day Initiation in Patients Hospitalized for Acute Schizophrenia Transitioned to Outpatient Care: Phase 3, Randomized, Double-Blind, Active-Control ALPINE Study

Autor: Ethan Cash, Jelena Kunovac, Sergey Yagoda, Yangchun Du, Amy Claxton, Peter J. Weiden, Ilda Bidollari, David P. Walling, Baiyun Yao, Elizabeth Keane

Publikováno v: The Journal of clinical psychiatry. 81(3)

OBJECTIVE Evaluate efficacy and safety of a 2-month formulation of aripiprazole lauroxil (AL) with 1-day initiation during hospitalization for acute exacerbation of schizophrenia followed by transition to outpatient care. METHODS The phase 3b double-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a6861c294c64a4fdbc3202d283ddb2
https://pubmed.ncbi.nlm.nih.gov/32433835

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