Výsledky vyhledávání - "Amy C. Wollish"

The Viral Interferon Regulatory Factors of Kaposi's Sarcoma-Associated Herpesvirus Differ in Their Inhibition of Interferon Activation Mediated by Toll-Like Receptor 3

Autor: Blossom Damania, Amy C. Wollish, Mark T. Heise, Sarah R. Jacobs, David J. Blackbourn, Sean M. Gregory, Christopher L. Bennett, John A. West

Publikováno v: Journal of Virology. 87:798-806

Kaposi's sarcoma-associated herpesvirus (KSHV) infection is correlated with three human malignancies and can establish lifelong latent infection in multiple cell types within its human host. In order to establish and maintain infection, KSHV utilizes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa92eff82d4f16b90424e4ecfaf39324
https://doi.org/10.1128/jvi.01851-12

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An attenuating mutation in a neurovirulent Sindbis virus strain interacts with the IPS-1 signaling pathway in vivo

Autor: Mark T. Heise, Yueh Ming Loo, Michael Gale, Amy C. Wollish, Martin T. Ferris, Lance K. Blevins

Publikováno v: Virology. 435:269-280

The AR86 strain of Sindbis virus causes lethal neurologic disease in adult mice. Previous studies have identified a virulence determinant at nonstructural protein (nsP) 1 position 538 that regulates neurovirulence, modulates clearance from the CNS, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f8967871aaaa0cd7f17079254c0db8
https://doi.org/10.1016/j.virol.2012.09.008

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A Determinant of Sindbis Virus Neurovirulence Enables Efficient Disruption of Jak/STAT Signaling ▿

Autor: Amy C. Wollish, Mark T. Heise, Jason D. Simmons

Previous studies with Venezuelan equine encephalitis virus and Sindbis virus (SINV) indicate that alphaviruses are capable of suppressing the cellular response to type I and type II interferons (IFNs) by disrupting Jak/STAT signaling; however, the re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd57e5db2de792e971931069b92552b
https://europepmc.org/articles/PMC2953173/

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Matching Biochemical Reaction Kinetics to the Timescales of Life: Structural Determinants That Influence the Autodephosphorylation Rate of Response Regulator Proteins

Autor: Amy C. Wollish, Stephanie A. Thomas, Edward J. Collins, Peter J. Miller, Robert B. Bourret, Yael Pazy, Ruth E. Silversmith

In two-component regulatory systems, covalent phosphorylation typically activates the response regulator signaling protein, and hydrolysis of the phosphoryl group reestablishes the inactive state. Despite highly conserved three-dimensional structures

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