Výsledky vyhledávání - "Amy C. Richards"

Akademický článek

The Staphylococcus aureus superantigen SElX is a bifunctional toxin that inhibits neutrophil function.

Autor: Stephen W Tuffs, David B A James, Jovanka Bestebroer, Amy C Richards, Mariya I Goncheva, Marie O'Shea, Bryan A Wee, Keun Seok Seo, Patrick M Schlievert, Andreas Lengeling, Jos A van Strijp, Victor J Torres, J Ross Fitzgerald

Publikováno v: PLoS Pathogens, Vol 13, Iss 9, p e1006461 (2017)

Bacterial superantigens (SAgs) cause Vβ-dependent T-cell proliferation leading to immune dysregulation associated with the pathogenesis of life-threatening infections such as toxic shock syndrome, and necrotizing pneumonia. Previously, we demonstrat

Externí odkaz: https://doaj.org/article/ae54e40195464ed8bfce66dbe8119856

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Recombination-mediated remodelling of host–pathogen interactions during Staphylococcus aureus niche adaptation

Autor: Paul R. McAdam, Chriselle Mendonca, Amy C. Richards, Jukka Corander, Emily J Richardson, James P. O'Gara, Nikki S. Black, J. Ross Fitzgerald, Laura E. Spoor, Stephen Nutbeam-Tuffs, Chia Y. Lee, Ravi Kr. Gupta, Gillian J. Wilson

Publikováno v: Microbial Genomics
Spoor, L E, Richardson, E, Richards, A C, Wilson, G J, Mendonca, C, Gupta, R K, Mcadam, P R, Nutbeam-tuffs, S, Black, N S, O'gara, J P, Lee, C Y, Corander, J & Fitzgerald, R 2015, ' Recombination-mediated remodelling of host-pathogen interactions during Staphylococcus aureus niche adaptation ', Microbial Genomics, vol. 1, no. 4 . https://doi.org/10.1099/mgen.0.000036
BASE-Bielefeld Academic Search Engine

Large-scale recombination events have led to the emergence of epidemic clones of several major bacterial pathogens. However, the functional impact of the recombination on clonal success is not understood. Here, we identified a novel widespread hybrid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b211e416a42850f896c3c868093ff26a
http://europepmc.org/articles/PMC5320625

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Fibronectin Binding Proteins SpsD and SpsL Both Support Invasion of Canine Epithelial Cells by Staphylococcus pseudintermedius

Autor: Simonetta Rindi, J. Ross Fitzgerald, Timothy J. Foster, Amy C. Richards, Pietro Speziale, Valentina Gianotti, Andrea S. Bordt, Ian R. Monk, Giampiero Pietrocola, Joan A. Geoghegan, Giulia Nobile

Publikováno v: Infection and immunity. 83(10)

In this study, we investigated the cell wall-anchored fibronectin-binding proteins SpsD and SpsL from the canine commensal and pathogen Staphylococcus pseudintermedius for their role in promoting bacterial invasion of canine progenitor epidermal kera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f1f59cc6e6c3be94d01d44a4702b8c
https://pubmed.ncbi.nlm.nih.gov/26238710

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Electronic MEMS for triggered delivery

Autor: Michael J. Cima, Rebecca S. Shawgo, Yawen Li, Amy C. Richards Grayson

Publikováno v: Advanced Drug Delivery Reviews. 56:173-184

Implantable electronic devices such as pacemakers and neural implants are often used for electrical stimulation. The usage of microfabrication techniques to produce microelectromechanical systems (MEMS) has allowed engineers to address a wider range

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bddb630e34a61bf1e1408236d581e44d
https://doi.org/10.1016/j.addr.2003.07.012

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Molecular release from a polymeric microreservoir device: Influence of chemistry, polymer swelling, and loading on device performance

Autor: Michael J. Cima, Amy C. Richards Grayson, Robert Langer

Publikováno v: Journal of Biomedical Materials Research. :502-512

A polymeric microreservoir device for controlled-release drug delivery relies on the degradation of thin poly(lactic-co-glycolic acid) membranes that seal each reservoir to achieve pulsatile drug delivery. In vitro release studies in which the swelli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1273cb5d64844961c08ad0b1bfacfcbc
https://doi.org/10.1002/jbm.a.30019

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Differential degradation rates in vivo and in vitro of biocompatible poly(lactic acid) and poly(glycolic acid) homo- and co-polymers for a polymeric drug-delivery microchip

Autor: Amy C. Richards Grayson, Aaron Lynn, James M. Anderson, Robert Langer, Michael J. Cima, Gabriela Voskerician

Publikováno v: Journal of Biomaterials Science, Polymer Edition. 15:1281-1304

The biocompatibility and biodegradation rate of component materials are critical when designing a drug-delivery device. The degradation products and rate of degradation may play important roles in determining the local cellular response to the implan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3639220be0f040748c828f68702e1d
https://doi.org/10.1163/1568562041959991

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A BioMEMS Review: MEMS Technology for Physiologically Integrated Devices

Autor: Rebecca S. Shawgo, Nolan T. Flynn, Audrey M. Johnson, Yawen Li, Amy C. Richards Grayson, Robert Langer, Michael J. Cima

Publikováno v: Proceedings of the IEEE. 92:6-21

MEMS devices are manufactured using similar microfabrication techniques as those used to create integrated circuits. They often, however, have moving components that allow physical or analytical functions to be performed by the device. Although MEMS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ff8c69dfaced24b7ca0160e565cf0fc
https://doi.org/10.1109/jproc.2003.820534

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Multi-pulse drug delivery from a resorbable polymeric microchip device

Autor: Michael J. Cima, Insung S. Choi, Robert Langer, Amy C. Richards Grayson, Henry Brem, Betty Tyler, Paul P. Wang

Publikováno v: Nature Materials. 2:767-772

Controlled-release drug delivery systems have many applications, including treatments for hormone deficiencies and chronic pain. A biodegradable device that could provide multi-dose drug delivery would be advantageous for long-term treatment of condi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::479712852fb2f7373519a0b5a1f36dcb
https://doi.org/10.1038/nmat998

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Microchips as Controlled Drug-Delivery Devices

Autor: Rebecca Scheidt, Amy C. Richards, Michael J. Cima, John T. Santini, Robert Langer

Publikováno v: Angewandte Chemie International Edition. 39:2396-2407

Controlled-release systems are common in a number of product areas, including foods, cosmetics, pesticides, and paper. Microencapsulated systems, for example, are used for the release of flavors and vitamins in foods, fragrances in perfumes, and inks

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b01d26ea26c73af1e19cfde2970b0e11
https://doi.org/10.1002/1521-3773(20000717)39:14<2396::aid-anie2396>3.0.co

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