Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Amy C Anderson"'
Autor:
Behnoush Hajian, Eric Scocchera, Santosh Keshipeddy, Narendran G-Dayanandan, Carolyn Shoen, Jolanta Krucinska, Stephanie Reeve, Michael Cynamon, Amy C Anderson, Dennis L Wright
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161740 (2016)
Mycobacterium tuberculosis continues to cause widespread, life-threatening disease. In the last decade, this threat has grown dramatically as multi- and extensively-drug resistant (MDR and XDR) bacteria have spread globally and the number of agents t
Externí odkaz:
https://doaj.org/article/efa43d29055a4aac8d2f815c84430a91
Autor:
Kishore Viswanathan, Kathleen M Frey, Eric W Scocchera, Brooke D Martin, P Whitney Swain Iii, Jeremy B Alverson, Nigel D Priestley, Amy C Anderson, Dennis L Wright
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e29434 (2012)
Hospital- and community-acquired, complicated skin and soft tissue infections, often attributed to Staphylococcus aureus and Streptococcus pyogenes, present a significant health burden that is associated with increased health care costs and mortality
Externí odkaz:
https://doaj.org/article/8abb7d77208542169fe2fe0daa5bd32b
Autor:
Eric R. Falcone, Akram Hazeen, Amy C. Anderson, Heidi Erlandsen, Jolanta Krucinska, Dennis L. Wright, Alexavier Estrada, Michael N. Lombardo, Victoria L. Robinson
Publikováno v:
Biochemistry. 58:1188-1197
Enolase is a glycolytic metalloenzyme involved in carbon metabolism. The advantage of targeting enolase lies in its essentiality in many biological processes such as cell wall formation and RNA turnover and as a plasminogen receptor. We initially use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a27c4def4095f1daecd1c4a8d318e01
https://doi.org/10.1021/acs.biochem.8b01298
https://doi.org/10.1021/acs.biochem.8b01298
Autor:
Dennis L. Wright, Ross Thyer, Michael B. Cammarata, Jennifer S. Brodbelt, Michael N. Lombardo, Andrew D. Ellington, Amy C. Anderson
Publikováno v:
Chemical Science. 8:4062-4072
Pathogenic Escherichia coli, one of the primary causes of urinary tract infections, has shown significant resistance to the most popular antibiotic, trimethoprim (TMP), which inhibits dihydrofolate reductase (DHFR). The resistance is modulated by sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13c49c3e633d244884dd03e4cd020666
https://doi.org/10.1039/c6sc05235e
https://doi.org/10.1039/c6sc05235e
Autor:
Eric R. Falcone, Sarah A. Holstein, Dennis L. Wright, Jin Li, Amy C. Anderson, Andrew J. Wiemer
Publikováno v:
Pharmacological Research. 113:438-448
Tropolones, such as β-thujaplicin, are small lead-like natural products that possess a variety of biological activities. While the β-substituted natural products and their synthetic analogs are potent inhibitors of human cancer cell growth, less is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8703f43b85d6f3947a6764fe478c2d
https://doi.org/10.1016/j.phrs.2016.09.020
https://doi.org/10.1016/j.phrs.2016.09.020
Autor:
Michael N. Lombardo, Amy C. Anderson, Behnoush Hajian, Nigel D. Priestley, Jeremy B. Alverson, Stephanie M. Reeve, Adrienne E. Sochia, Eric W. Scocchera, Santosh Keshipeddy, Dennis L. Wright
Publikováno v:
ACS Medicinal Chemistry Letters. 7:692-696
Although classical, negatively charged antifolates such as methotrexate possess high affinity for the dihydrofolate reductase (DHFR) enzyme, they are unable to penetrate the bacterial cell wall, rendering them poor antibacterial agents. Herein, we re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823d3378c243ec1a2720df94ddd56a00
https://doi.org/10.1021/acsmedchemlett.6b00120
https://doi.org/10.1021/acsmedchemlett.6b00120
Publikováno v:
ACS Infectious Diseases. 2:149-156
Multidrug-resistant Enterobacteriaceae, notably Escherichia coli and Klebsiella pneumoniae, have become major health concerns worldwide. Resistance to effective therapeutics is often carried by class I and II integrons that can confer insensitivity t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e329f0294f035ed12035b7c3fcf8dff
https://doi.org/10.1021/acsinfecdis.5b00129
https://doi.org/10.1021/acsinfecdis.5b00129
Understanding the structural mechanisms of antibiotic resistance sets the platform for new discovery
Publikováno v:
Future Microbiology. 10:1727-1733
Understanding the structural basis of antibacterial resistance may enable rational design principles that avoid and subvert that resistance, thus leading to the discovery of more effective antibiotics. In this review, we explore the use of crystal st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::887caf16aade2e9582a19f2c6c8d741e
https://doi.org/10.2217/fmb.15.78
https://doi.org/10.2217/fmb.15.78
Autor:
Hossein Heidari-Torkabadi, Amy C. Anderson, Michael N. Lombardo, Paul R. Carey, Dennis L. Wright, Tao Che
Publikováno v:
Biochemistry. 54:2719-2726
We report the first Raman spectroscopic study of propargyl-linked dihydrofolate reductase (DHFR) inhibitors being taken up by wild type Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus cells. A novel protocol is developed where cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617e430077ed81ccec570067fabb5d30
https://doi.org/10.1021/acs.biochem.5b00202
https://doi.org/10.1021/acs.biochem.5b00202
Autor:
Santosh Keshipeddy, John Hoody, Dennis L. Wright, Larissa Walker, Nigel D. Priestley, Amy C. Anderson, Jeremy B. Alverson, Patrick A. Barney
Antimicrobial resistance to current antibiotics is a significant public health problem and the need for new antibiotics is a compelling one. We have been developing a new series of antibiotics, propargyl-linked diaminopyrimidines, based on the struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe10ec7ad6a9c66a10aff784f2d5712
https://europepmc.org/articles/PMC5635995/
https://europepmc.org/articles/PMC5635995/
